ID F9ZZB2_METMM Unreviewed; 360 AA. AC F9ZZB2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 27-MAR-2024, entry version 69. DE RecName: Full=Alanine racemase {ECO:0000256|ARBA:ARBA00013089, ECO:0000256|HAMAP-Rule:MF_01201}; DE EC=5.1.1.1 {ECO:0000256|ARBA:ARBA00013089, ECO:0000256|HAMAP-Rule:MF_01201}; GN OrderedLocusNames=Metme_2756 {ECO:0000313|EMBL:AEG01138.1}; OS Methylomonas methanica (strain MC09). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales; OC Methylococcaceae; Methylomonas. OX NCBI_TaxID=857087 {ECO:0000313|EMBL:AEG01138.1, ECO:0000313|Proteomes:UP000008888}; RN [1] {ECO:0000313|EMBL:AEG01138.1, ECO:0000313|Proteomes:UP000008888} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MC09 {ECO:0000313|EMBL:AEG01138.1, RC ECO:0000313|Proteomes:UP000008888}; RX PubMed=22123758; DOI=10.1128/JB.06267-11; RA Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M.G., RA Jetten M.S., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H., RA Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.F., Goodwin L., RA Han C., Hauser L., Land M.L., Lapidus A., Lucas S., Pitluck S., Woyke T., RA Stein L., Murrell J.C.; RT "Complete Genome Sequence of the Aerobic Marine Methanotroph Methylomonas RT methanica MC09."; RL J. Bacteriol. 193:7001-7002(2011). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MC09; RA Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M., RA Jetten M., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H., RA Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.-F., Goodwin L., RA Han C., Hauser L., Land M., Lapidus A., Lucas S., Pitluck S., Woyke T., RA Stein L.Y., Murrell C.; RT "Complete genome sequence of the aerobic marine methanotroph Methylomonas RT methanica MC09."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Proteomes:UP000008888} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MC09 {ECO:0000313|Proteomes:UP000008888}; RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., RA Kyrpides N., Ivanova N., Pagani I., Stein L., Woyke T.; RT "Complete sequence of Methylomonas methanica MC09."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the interconversion of L-alanine and D-alanine. May CC also act on other amino acids. {ECO:0000256|HAMAP-Rule:MF_01201}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249, CC ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01201}; CC -!- COFACTOR: CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; CC Evidence={ECO:0000256|ARBA:ARBA00001933, ECO:0000256|HAMAP- CC Rule:MF_01201, ECO:0000256|PIRSR:PIRSR600821-50}; CC -!- PATHWAY: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine CC from L-alanine: step 1/1. {ECO:0000256|ARBA:ARBA00037912, CC ECO:0000256|HAMAP-Rule:MF_01201}. CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|ARBA:ARBA00004752}. CC -!- SIMILARITY: Belongs to the alanine racemase family. {ECO:0000256|HAMAP- CC Rule:MF_01201}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002738; AEG01138.1; -; Genomic_DNA. DR RefSeq; WP_013819373.1; NC_015572.1. DR AlphaFoldDB; F9ZZB2; -. DR STRING; 857087.Metme_2756; -. DR KEGG; mmt:Metme_2756; -. DR eggNOG; COG0787; Bacteria. DR HOGENOM; CLU_028393_1_0_6; -. DR OrthoDB; 9813814at2; -. DR UniPathway; UPA00042; UER00497. DR Proteomes; UP000008888; Chromosome. DR GO; GO:0008784; F:alanine racemase activity; IEA:UniProtKB-UniRule. DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule. DR GO; GO:0030632; P:D-alanine biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd06827; PLPDE_III_AR_proteobact; 1. DR Gene3D; 3.20.20.10; Alanine racemase; 1. DR HAMAP; MF_01201; Ala_racemase; 1. DR InterPro; IPR000821; Ala_racemase. DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C. DR InterPro; IPR011079; Ala_racemase_C. DR InterPro; IPR001608; Ala_racemase_N. DR InterPro; IPR020622; Ala_racemase_pyridoxalP-BS. DR InterPro; IPR029066; PLP-binding_barrel. DR NCBIfam; TIGR00492; alr; 1. DR PANTHER; PTHR30511; ALANINE RACEMASE; 1. DR PANTHER; PTHR30511:SF4; ALANINE RACEMASE, BIOSYNTHETIC; 1. DR Pfam; PF00842; Ala_racemase_C; 1. DR Pfam; PF01168; Ala_racemase_N; 1. DR PRINTS; PR00992; ALARACEMASE. DR SMART; SM01005; Ala_racemase_C; 1. DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1. DR SUPFAM; SSF51419; PLP-binding barrel; 1. DR PROSITE; PS00395; ALANINE_RACEMASE; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_01201}; KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898, ECO:0000256|HAMAP- KW Rule:MF_01201}; Reference proteome {ECO:0000313|Proteomes:UP000008888}. FT DOMAIN 235..359 FT /note="Alanine racemase C-terminal" FT /evidence="ECO:0000259|SMART:SM01005" FT ACT_SITE 35 FT /note="Proton acceptor; specific for D-alanine" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01201" FT ACT_SITE 256 FT /note="Proton acceptor; specific for L-alanine" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01201" FT BINDING 131 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01201, FT ECO:0000256|PIRSR:PIRSR600821-52" FT BINDING 304 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01201, FT ECO:0000256|PIRSR:PIRSR600821-52" FT MOD_RES 35 FT /note="N6-(pyridoxal phosphate)lysine" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01201, FT ECO:0000256|PIRSR:PIRSR600821-50" SQ SEQUENCE 360 AA; 39098 MW; C51CF616BB125FDD CRC64; MTPAAYVHLD LDAVRHNLAQ AKRYAPNNKI MAVIKANGYG HGITRVAKAL EQADGLAVAR VDEGVRLRKA GFSQPITVLQ GFVCIDELHL MLQHQLDAVI HTPQQISLLQ QQTGLQAALS VWLKMDTGMN RLGFKGADFN AAYQQLLNCP LVKQPINLIT HFANADDLLD DKTRKQIDLF NDAVQGYPGQ RSIANSAGII GWPNVVSDWV RPGLMLYGCS PFAGKTGADF GLRPVMSLHS RLIAVKNVAA GETVGYSGTW QCQTDTRLGV ISIGYGDGYH RHTRAGAPVL VNGRRAPLIG RVSMDMITID LNSQPAAQPG DPVTLWGDGL PVEEIARHAD TIPYTLLCGI TQRVQIVEQA //