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Protein

Alanine racemase

Gene

Metme_2756

Organism
Methylomonas methanica (strain MC09)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Metme_2756)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMMET857087:GH4A-2781-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Metme_2756Imported
OrganismiMethylomonas methanica (strain MC09)Imported
Taxonomic identifieri857087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylomonas
ProteomesiUP000008888 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi857087.Metme_2756.

Structurei

3D structure databases

ProteinModelPortaliF9ZZB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9ZZB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPAAYVHLD LDAVRHNLAQ AKRYAPNNKI MAVIKANGYG HGITRVAKAL
60 70 80 90 100
EQADGLAVAR VDEGVRLRKA GFSQPITVLQ GFVCIDELHL MLQHQLDAVI
110 120 130 140 150
HTPQQISLLQ QQTGLQAALS VWLKMDTGMN RLGFKGADFN AAYQQLLNCP
160 170 180 190 200
LVKQPINLIT HFANADDLLD DKTRKQIDLF NDAVQGYPGQ RSIANSAGII
210 220 230 240 250
GWPNVVSDWV RPGLMLYGCS PFAGKTGADF GLRPVMSLHS RLIAVKNVAA
260 270 280 290 300
GETVGYSGTW QCQTDTRLGV ISIGYGDGYH RHTRAGAPVL VNGRRAPLIG
310 320 330 340 350
RVSMDMITID LNSQPAAQPG DPVTLWGDGL PVEEIARHAD TIPYTLLCGI
360
TQRVQIVEQA
Length:360
Mass (Da):39,098
Last modified:October 19, 2011 - v1
Checksum:iC51CF616BB125FDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002738 Genomic DNA. Translation: AEG01138.1.
RefSeqiWP_013819373.1. NC_015572.1.

Genome annotation databases

EnsemblBacteriaiAEG01138; AEG01138; Metme_2756.
KEGGimmt:Metme_2756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002738 Genomic DNA. Translation: AEG01138.1.
RefSeqiWP_013819373.1. NC_015572.1.

3D structure databases

ProteinModelPortaliF9ZZB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi857087.Metme_2756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG01138; AEG01138; Metme_2756.
KEGGimmt:Metme_2756.

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMMET857087:GH4A-2781-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the aerobic marine methanotroph Methylomonas methanica MC09."
    Boden R., Cunliffe M., Scanlan J., Moussard H., Kits K.D., Klotz M., Jetten M., Vuilleumier S., Han J., Peters L., Mikhailova N., Teshima H., Tapia R., Kyrpides N., Ivanova N., Pagani I., Cheng J.-F., Goodwin L.
    , Han C., Hauser L., Land M., Lapidus A., Lucas S., Pitluck S., Woyke T., Stein L.Y., Murrell C.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC09.
  2. "Complete sequence of Methylomonas methanica MC09."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Stein L., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC09Imported.

Entry informationi

Entry nameiF9ZZB2_METMM
AccessioniPrimary (citable) accession number: F9ZZB2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 22, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.