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F9ZRS3

- F9ZRS3_ACICS

UniProt

F9ZRS3 - F9ZRS3_ACICS

Protein

Isocitrate dehydrogenase [NADP]

Gene

Atc_2440

Organism
Acidithiobacillus caldus (strain SM-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciACAL990288:GJBS-2477-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Atc_2440Imported
    OrganismiAcidithiobacillus caldus (strain SM-1)Imported
    Taxonomic identifieri990288 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
    ProteomesiUP000006135: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F9ZRS3-1 [UniParc]FASTAAdd to Basket

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    MSGGSLIRWA AGRLEVPDRP IIPFIEGDGI GVDVTPAMRR VVDAAVAKAY    50
    GGARAIVWRE LLAGQKAVAE LGADQILPEA TLAAIREHHV AIKGPLETPV 100
    GTGMRSLNVA LRQELDLYVC QRPVRYFRGT PSPLREPEKV DMVIFRENSE 150
    DIYAGIEWPA ESPEARRLIA FLREEMGVRK IRFPESSAIG IKPVSREGSE 200
    RLIRRAIAYA LAQGKPSVTL VHKGNIMKFT EGGFRDWGYA LAEREFGEQV 250
    FTWRQKTALA KSEGKAAAEA AEKAAVAAGK LIVKDVIADN FLQQILLRPE 300
    LYSVVATLNL NGDYLSDALA AEVGGIGMAP GANLSDSHAI FEATHGTAPD 350
    IAGLGRANPS SLILSAVMLL EHIGWPEAAE RILAAMEATI GAGEVTADLA 400
    ALRGDVPALS TAEFTAALCR RVEA 424
    Length:424
    Mass (Da):45,501
    Last modified:October 19, 2011 - v1
    Checksum:iC6ECB6ABE0389E92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002573 Genomic DNA. Translation: AEK59088.1.
    RefSeqiYP_004749790.1. NC_015850.1.

    Genome annotation databases

    EnsemblBacteriaiAEK59088; AEK59088; Atc_2440.
    GeneIDi10990225.
    KEGGiacu:Atc_2440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002573 Genomic DNA. Translation: AEK59088.1 .
    RefSeqi YP_004749790.1. NC_015850.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEK59088 ; AEK59088 ; Atc_2440 .
    GeneIDi 10990225.
    KEGGi acu:Atc_2440.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci ACAL990288:GJBS-2477-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation."
      You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.
      J. Genet. Genomics 38:243-252(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SM-1Imported.

    Entry informationi

    Entry nameiF9ZRS3_ACICS
    AccessioniPrimary (citable) accession number: F9ZRS3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3