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F9ZRS3

- F9ZRS3_ACICS

UniProt

F9ZRS3 - F9ZRS3_ACICS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Atc_2440

Organism
Acidithiobacillus caldus (strain SM-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciACAL990288:GJBS-2477-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Atc_2440Imported
OrganismiAcidithiobacillus caldus (strain SM-1)Imported
Taxonomic identifieri990288 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
ProteomesiUP000006135: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9ZRS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGGSLIRWA AGRLEVPDRP IIPFIEGDGI GVDVTPAMRR VVDAAVAKAY
60 70 80 90 100
GGARAIVWRE LLAGQKAVAE LGADQILPEA TLAAIREHHV AIKGPLETPV
110 120 130 140 150
GTGMRSLNVA LRQELDLYVC QRPVRYFRGT PSPLREPEKV DMVIFRENSE
160 170 180 190 200
DIYAGIEWPA ESPEARRLIA FLREEMGVRK IRFPESSAIG IKPVSREGSE
210 220 230 240 250
RLIRRAIAYA LAQGKPSVTL VHKGNIMKFT EGGFRDWGYA LAEREFGEQV
260 270 280 290 300
FTWRQKTALA KSEGKAAAEA AEKAAVAAGK LIVKDVIADN FLQQILLRPE
310 320 330 340 350
LYSVVATLNL NGDYLSDALA AEVGGIGMAP GANLSDSHAI FEATHGTAPD
360 370 380 390 400
IAGLGRANPS SLILSAVMLL EHIGWPEAAE RILAAMEATI GAGEVTADLA
410 420
ALRGDVPALS TAEFTAALCR RVEA
Length:424
Mass (Da):45,501
Last modified:October 19, 2011 - v1
Checksum:iC6ECB6ABE0389E92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK59088.1.
RefSeqiYP_004749790.1. NC_015850.1.

Genome annotation databases

EnsemblBacteriaiAEK59088; AEK59088; Atc_2440.
GeneIDi10990225.
KEGGiacu:Atc_2440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK59088.1 .
RefSeqi YP_004749790.1. NC_015850.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEK59088 ; AEK59088 ; Atc_2440 .
GeneIDi 10990225.
KEGGi acu:Atc_2440.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci ACAL990288:GJBS-2477-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation."
    You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.
    J. Genet. Genomics 38:243-252(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM-1Imported.

Entry informationi

Entry nameiF9ZRS3_ACICS
AccessioniPrimary (citable) accession number: F9ZRS3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 26, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3