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Protein

Isocitrate dehydrogenase [NADP]

Gene

Atc_2440

Organism
Acidithiobacillus caldus (strain SM-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciACAL990288:GJBS-2477-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Atc_2440Imported
OrganismiAcidithiobacillus caldus (strain SM-1)Imported
Taxonomic identifieri990288 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
ProteomesiUP000006135 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9ZRS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGSLIRWA AGRLEVPDRP IIPFIEGDGI GVDVTPAMRR VVDAAVAKAY
60 70 80 90 100
GGARAIVWRE LLAGQKAVAE LGADQILPEA TLAAIREHHV AIKGPLETPV
110 120 130 140 150
GTGMRSLNVA LRQELDLYVC QRPVRYFRGT PSPLREPEKV DMVIFRENSE
160 170 180 190 200
DIYAGIEWPA ESPEARRLIA FLREEMGVRK IRFPESSAIG IKPVSREGSE
210 220 230 240 250
RLIRRAIAYA LAQGKPSVTL VHKGNIMKFT EGGFRDWGYA LAEREFGEQV
260 270 280 290 300
FTWRQKTALA KSEGKAAAEA AEKAAVAAGK LIVKDVIADN FLQQILLRPE
310 320 330 340 350
LYSVVATLNL NGDYLSDALA AEVGGIGMAP GANLSDSHAI FEATHGTAPD
360 370 380 390 400
IAGLGRANPS SLILSAVMLL EHIGWPEAAE RILAAMEATI GAGEVTADLA
410 420
ALRGDVPALS TAEFTAALCR RVEA
Length:424
Mass (Da):45,501
Last modified:October 19, 2011 - v1
Checksum:iC6ECB6ABE0389E92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK59088.1.
RefSeqiWP_004868721.1. NC_015850.1.

Genome annotation databases

EnsemblBacteriaiAEK59088; AEK59088; Atc_2440.
KEGGiacu:Atc_2440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK59088.1.
RefSeqiWP_004868721.1. NC_015850.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK59088; AEK59088; Atc_2440.
KEGGiacu:Atc_2440.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciACAL990288:GJBS-2477-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation."
    You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.
    J. Genet. Genomics 38:243-252(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM-1Imported.

Entry informationi

Entry nameiF9ZRS3_ACICS
AccessioniPrimary (citable) accession number: F9ZRS3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 22, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.