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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Acidithiobacillus caldus (strain SM-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471UniRule annotation
Active sitei587 – 5871UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciACAL990288:GJBS-1817-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Atc_1791Imported
OrganismiAcidithiobacillus caldus (strain SM-1)Imported
Taxonomic identifieri990288 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
ProteomesiUP000006135 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9ZP62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKVPNDR ALRARVKRLG NLLGEVLKEQ AGDRVFNAVE QLRQGYIRLH
60 70 80 90 100
RREDPKLRKR LARFIDALPQ DDLVLVIRAF NTYFSLVNIA EEEFQHLQRR
110 120 130 140 150
RLLQRSEALW VGSFEETFRA LQQQGIHSGQ LQYLLGQIRY LPVFTAHPTE
160 170 180 190 200
SKRRTVLHGL RRIFLTSKML DDPSLSQEEE NDVLRQLKAQ IQILWETEEV
210 220 230 240 250
RSNRPQVQDE VENGLFYFRD SLFNAVPMCY HAARRAVRRV YGNPNVDIPA
260 270 280 290 300
FIRFGSWIGG DRDGNPNVTA AITGWALRTQ SMEVLREYQR RLADLYQLLG
310 320 330 340 350
HSSRFCAVSP VLLASLERDA DDFPELAEWV NQRFPSEPYR RKLRYMMTRL
360 370 380 390 400
DLRLRQLENG QILNEAAGPG YSSASEFLED LLLVRDSLRG HRDHYIAEHD
410 420 430 440 450
VQNLVWLLET FGFHLAALDI RQESTVHGQT IAELFRDVAG FANYLEQPEE
460 470 480 490 500
QRLLTLAEAL RRPGCLVTET PELSPLAAET CAMFRCIAQL RREVSPEAFG
510 520 530 540 550
SYVISMTHEA SHILEVLLLA KEFGLAGWSR EGLYSEIAVT PLFETIHDLE
560 570 580 590 600
RMEAVMSRLL DDPVYAEILR SQGNLQEVML GYSDSCKDGG ILSSSWSLYQ
610 620 630 640 650
AQIRLAELAD RRRIQIRVFH GRGGSVGRGG GPTYEAIMAQ PPDTVRGQIK
660 670 680 690 700
ITEQGEVLSF KYANLETAVY ELTVGVAGLI RASVGLVRRV ELDRPDYLQV
710 720 730 740 750
MSELVEIGEA VYRDLTEHTP GFMDYFYEAT PLNEIAHMNI GSRPSHRHRG
760 770 780 790 800
DRSMASIRAI PWVFAWAQSR HVLPAWYGLG SALARWRGDD PDRLNTLRDM
810 820 830 840 850
AKHWPFFRAL LGNISMAMAK THLDLAREYA GLPQDQECAQ KIFAKIRAEY
860 870 880 890 900
ELSLAELLTA LDLPAPLADN PTLAFSLQRR NVYMEPLNHI QLALLRRYRN
910 920 930
EDTPQEFRET WLDPLLRTIN AIAAGQRNTG
Length:930
Mass (Da):106,485
Last modified:October 18, 2011 - v1
Checksum:iFCC4B6B1DC3072E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK58439.1.
RefSeqiYP_004749140.1. NC_015850.1.

Genome annotation databases

EnsemblBacteriaiAEK58439; AEK58439; Atc_1791.
KEGGiacu:Atc_1791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002573 Genomic DNA. Translation: AEK58439.1.
RefSeqiYP_004749140.1. NC_015850.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEK58439; AEK58439; Atc_1791.
KEGGiacu:Atc_1791.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciACAL990288:GJBS-1817-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation."
    You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.
    J. Genet. Genomics 38:243-252(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM-1Imported.

Entry informationi

Entry nameiF9ZP62_ACICS
AccessioniPrimary (citable) accession number: F9ZP62
Entry historyi
Integrated into UniProtKB/TrEMBL: October 18, 2011
Last sequence update: October 18, 2011
Last modified: March 31, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.