F9ZM18 (F9ZM18_ACICS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP-Rule MF_00523
EC=2.3.1.- HAMAP-Rule MF_00523

Gene names

Name:	lpxD HAMAP-Rule MF_00523
Ordered Locus Names:	Atc_0851 EMBL AEK57500.1

Organism

Acidithiobacillus caldus (strain SM-1) [Complete proteome] [HAMAP]

Taxonomic identifier

990288 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus › Acidithiobacillus caldus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00523 SAAS SAAS007691
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP-Rule MF_00523 SAAS SAAS007691
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP-Rule MF_00523 SAAS SAAS007691
Subunit structure	Homotrimer By similarity. HAMAP-Rule MF_00523 SAAS SAAS007691
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP-Rule MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP-Rule MF_00523 SAAS SAAS007691 Lipid biosynthesis Lipid metabolism
Domain	Repeat HAMAP-Rule MF_00523 SAAS SAAS007691
Molecular function	Acyltransferase HAMAP-Rule MF_00523 SAAS SAAS007691 EMBL AEK57500.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	249	1	Proton acceptor By similarity HAMAP-Rule MF_00523

Sequences

	Sequence		Length	Mass (Da)
	F9ZM18 [UniParc]. Last modified October 19, 2011. Version 1. Checksum: 50D1E9ECA844059D	FASTA	360	37,775
	10 20 30 40 50 60 MAGKAVSRSA TTSASLAELA QVARAELRGD GHFQILGVAP LEAAGPHDLS FFQPPRSPQI 70 80 90 100 110 120 LAETRAGALI LREQELSLYE GNALVSRNPY ASFARVLQHL YPAPRPAPGV DEGAWIAVDA 130 140 150 160 170 180 HIHPAARIEA GVRVASGAVV EDGCWLETGV VVGAGVRLGA GCHLFPGVKV YAGVQIGPNC 190 200 210 220 230 240 SIHANAVIGA DGFGFAPDGD AYLKIPHIGG VRIGRDVEIG ANSCIDRGVM ADTVIGDGVK 250 260 270 280 290 300 IDNLVQIGHN VRIGEHTVIA GQTGVSGSTT IGAHCRIGGQ VGFAGHIRIA DGCIIAGQSA 310 320 330 340 350 360 ITHDLRTPGV YSGVLPARPA RRWRRLAARF DTLEEFVQRF KQWEKTAAAR ASAHREESDD

References

[1]

"Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation." You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J. J. Genet. Genomics 38:243-252(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SM-1 EMBL AEK57500.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002573 Genomic DNA. Translation: AEK57500.1.
RefSeq	YP_004748200.1. NC_015850.1.
3D structure databases
ProteinModelPortal	F9ZM18.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEK57500; AEK57500; Atc_0851.
GeneID	10988637.
KEGG	acu:Atc_0851.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K02536.
Enzyme and pathway databases
BioCyc	ACAL990288:GJBS-865-MONOMER.
UniPathway	UPA00973.
Family and domain databases
HAMAP	MF_00523. LpxD.
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. lipid_A_lpxD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F9ZM18_ACICS

Accession

Primary (citable) accession number: F9ZM18

Entry history

Integrated into UniProtKB/TrEMBL:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)