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F9Z4U8

- F9Z4U8_ODOSD

UniProt

F9Z4U8 - F9Z4U8_ODOSD

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Protein

ATP-dependent 6-phosphofructokinase

Gene
pfkA, Odosp_0362
Organism
Odoribacter splanchnicus (strain ATCC 29572 / DSM 20712 / JCM 15291 / NCTC 10825 / 1651/6) (Bacteroides splanchnicus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi106 – 1061Magnesium; catalytic By similarityUniRule annotation
Active sitei131 – 1311Proton acceptor By similarityUniRule annotation
Binding sitei158 – 1581Allosteric activator ADP By similarityUniRule annotation
Binding sitei166 – 1661Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei226 – 2261Substrate By similarityUniRule annotation
Binding sitei250 – 2501Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 762ATP By similarityUniRule annotation
Nucleotide bindingi105 – 1084ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciOSPL709991:GI68-365-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Odosp_0362Imported
OrganismiOdoribacter splanchnicus (strain ATCC 29572 / DSM 20712 / JCM 15291 / NCTC 10825 / 1651/6) (Bacteroides splanchnicus)Imported
Taxonomic identifieri709991 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeOdoribacter
ProteomesiUP000006657: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 285Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni129 – 1313Substrate binding By similarityUniRule annotation
Regioni173 – 1753Substrate binding By similarityUniRule annotation
Regioni189 – 1913Allosteric activator ADP binding By similarityUniRule annotation
Regioni256 – 2594Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00850.
OMAiAKLERGH.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9Z4U8-1 [UniParc]FASTAAdd to Basket

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MGRIKRIGVL TSGGDAPGMN AAIRAVVRTA IFNGCEAYGI FGGYQGLIEG    50
DIKRLKSNDV SNIIQRGGTI LKSARSMEFR TPEGRTKAAQ MLAEHKIDAL 100
VVIGGDGSFT GAKLLIQEHD IPVVGIPGTI DNDLYGTDST IGYDTAVNTA 150
VEAVDKIKDT ASAHNRLFFV EVMGRDAGFI ALRTAIATGA EAVLVPEVET 200
DLTDLEHFIE KDYNPKTSSG IVIVAEGEKS GGAYSIAEKV AQKHPEYDIR 250
VSVLGHMQRG GSPSQFDRVL ASQLGAAAVD ALMDDQKSIM LGIMNKEIVH 300
VPFNKTIKHT KNLNPELLNL VRILSI 326
Length:326
Mass (Da):34,929
Last modified:October 19, 2011 - v1
Checksum:i3022F3FB43993F2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002544 Genomic DNA. Translation: ADY31457.1.
RefSeqiYP_004251637.1. NC_015160.1.

Genome annotation databases

EnsemblBacteriaiADY31457; ADY31457; Odosp_0362.
GeneIDi10252068.
KEGGiosp:Odosp_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002544 Genomic DNA. Translation: ADY31457.1 .
RefSeqi YP_004251637.1. NC_015160.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADY31457 ; ADY31457 ; Odosp_0362 .
GeneIDi 10252068.
KEGGi osp:Odosp_0362.

Phylogenomic databases

KOi K00850.
OMAi AKLERGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci OSPL709991:GI68-365-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29572 / DSM 20712 / JCM 15291 / NCTC 10825 / 1651/6.

Entry informationi

Entry nameiF9Z4U8_ODOSD
AccessioniPrimary (citable) accession number: F9Z4U8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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