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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhB

Organism
Ketogulonicigenium vulgare (strain WSH-001)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
LigandPyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhBImported
Ordered Locus Names:KVU_0667Imported
OrganismiKetogulonicigenium vulgare (strain WSH-001)Imported
Taxonomic identifieri759362 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeKetogulonicigenium
Proteomesi
  • UP000000692 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi759362.KVU_0667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S. Bacteria.
COG0508. LUCA.
KOiK00627.
OMAiSWRLGCD.
OrthoDBiPOG091H0NG1.

Family and domain databases

Gene3Di4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.

Sequencei

Sequence statusi: Complete.

F9Y470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEILMPAL SPTMEEGTIA KWLVAEGDTV KSGDILAEIE TDKATMEFEA
60 70 80 90 100
VDDGVIGKIL LPAGSEGVKV NTPMAILLED GETEAAAPKA AAPKVEAAPV
110 120 130 140 150
EAPKAAPVAA AAAPVEKGDR VFASPLARRI AADKGLDLNA IAGSGPKGRI
160 170 180 190 200
VRADVEGATA AKPAEAAKAP AAAAPTPAAP APVPTSSSAD QILKMYQGRD
210 220 230 240 250
YTEVKLDGMR KTIAARLTEA KQTVPHFYLR RSVNLDALMA FRADLNAKLG
260 270 280 290 300
PRGIKISVND FVIKACAIAL QQVPKANAIW AGDRVLQMKA SDVSIAVAVE
310 320 330 340 350
GGLFTPVIRD ADAKSISALS AEMKDLAKRA RDKKLQPQDY QGGSFSISNL
360 370 380 390 400
GMFGVENFDA VINPPQGAIL AVGAGIKKPI VGDDGEITTA TLMSLTLSVD
410 420
HRVIDGALGA HLLTAIVENL ENPLSMLA
Length:428
Mass (Da):44,430
Last modified:October 19, 2011 - v1
Checksum:iDF28E1294E6FD9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002018 Genomic DNA. Translation: AEM40506.1.
RefSeqiWP_014537612.1. NC_017384.1.
YP_005794502.1. NC_017384.1.

Genome annotation databases

EnsemblBacteriaiAEM40506; AEM40506; KVU_0667.
GeneIDi12373522.
KEGGikvl:KVU_0667.
PATRICifig|759362.5.peg.698.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF9Y470_KETVW
AccessioniPrimary (citable) accession number: F9Y470
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 7, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported