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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhB

Organism
Ketogulonicigenium vulgare (strain WSH-001)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
LigandPyruvateImported

Enzyme and pathway databases

BioCyciKVUL759362:G1GZO-694-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhBImported
Ordered Locus Names:KVU_0667Imported
OrganismiKetogulonicigenium vulgare (strain WSH-001)Imported
Taxonomic identifieri759362 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeKetogulonicigenium
Proteomesi
  • UP000000692 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi759362.KVU_0667

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini122 – 159Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili316 – 336Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
KOiK00627
OMAiSWRLGCD
OrthoDBiPOG091H0NG1

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

F9Y470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEILMPAL SPTMEEGTIA KWLVAEGDTV KSGDILAEIE TDKATMEFEA
60 70 80 90 100
VDDGVIGKIL LPAGSEGVKV NTPMAILLED GETEAAAPKA AAPKVEAAPV
110 120 130 140 150
EAPKAAPVAA AAAPVEKGDR VFASPLARRI AADKGLDLNA IAGSGPKGRI
160 170 180 190 200
VRADVEGATA AKPAEAAKAP AAAAPTPAAP APVPTSSSAD QILKMYQGRD
210 220 230 240 250
YTEVKLDGMR KTIAARLTEA KQTVPHFYLR RSVNLDALMA FRADLNAKLG
260 270 280 290 300
PRGIKISVND FVIKACAIAL QQVPKANAIW AGDRVLQMKA SDVSIAVAVE
310 320 330 340 350
GGLFTPVIRD ADAKSISALS AEMKDLAKRA RDKKLQPQDY QGGSFSISNL
360 370 380 390 400
GMFGVENFDA VINPPQGAIL AVGAGIKKPI VGDDGEITTA TLMSLTLSVD
410 420
HRVIDGALGA HLLTAIVENL ENPLSMLA
Length:428
Mass (Da):44,430
Last modified:October 19, 2011 - v1
Checksum:iDF28E1294E6FD9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002018 Genomic DNA Translation: AEM40506.1
RefSeqiWP_014537612.1, NC_017384.1
YP_005794502.1, NC_017384.1

Genome annotation databases

EnsemblBacteriaiAEM40506; AEM40506; KVU_0667
GeneIDi12373522
KEGGikvl:KVU_0667
PATRICifig|759362.5.peg.698

Similar proteinsi

Entry informationi

Entry nameiF9Y470_KETVW
AccessioniPrimary (citable) accession number: F9Y470
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health