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F9Y470

- F9Y470_KETVW

UniProt

F9Y470 - F9Y470_KETVW

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhB

Organism
Ketogulonicigenium vulgare (strain WSH-001)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • Note: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • Note: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciKVUL759362:GLEX-694-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhBImported
Ordered Locus Names:KVU_0667Imported
OrganismiKetogulonicigenium vulgare (strain WSH-001)Imported
Taxonomic identifieri759362 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeKetogulonicigenium
ProteomesiUP000000692: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9Y470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIEILMPAL SPTMEEGTIA KWLVAEGDTV KSGDILAEIE TDKATMEFEA
60 70 80 90 100
VDDGVIGKIL LPAGSEGVKV NTPMAILLED GETEAAAPKA AAPKVEAAPV
110 120 130 140 150
EAPKAAPVAA AAAPVEKGDR VFASPLARRI AADKGLDLNA IAGSGPKGRI
160 170 180 190 200
VRADVEGATA AKPAEAAKAP AAAAPTPAAP APVPTSSSAD QILKMYQGRD
210 220 230 240 250
YTEVKLDGMR KTIAARLTEA KQTVPHFYLR RSVNLDALMA FRADLNAKLG
260 270 280 290 300
PRGIKISVND FVIKACAIAL QQVPKANAIW AGDRVLQMKA SDVSIAVAVE
310 320 330 340 350
GGLFTPVIRD ADAKSISALS AEMKDLAKRA RDKKLQPQDY QGGSFSISNL
360 370 380 390 400
GMFGVENFDA VINPPQGAIL AVGAGIKKPI VGDDGEITTA TLMSLTLSVD
410 420
HRVIDGALGA HLLTAIVENL ENPLSMLA
Length:428
Mass (Da):44,430
Last modified:October 19, 2011 - v1
Checksum:iDF28E1294E6FD9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002018 Genomic DNA. Translation: AEM40506.1.
RefSeqiYP_005794502.1. NC_017384.1.

Genome annotation databases

EnsemblBacteriaiAEM40506; AEM40506; KVU_0667.
GeneIDi12373522.
KEGGikvl:KVU_0667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002018 Genomic DNA. Translation: AEM40506.1 .
RefSeqi YP_005794502.1. NC_017384.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEM40506 ; AEM40506 ; KVU_0667 .
GeneIDi 12373522.
KEGGi kvl:KVU_0667.

Phylogenomic databases

KOi K00627.

Enzyme and pathway databases

BioCyci KVUL759362:GLEX-694-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the industrial strain Ketogulonicigenium vulgare WSH-001."
    Liu L., Li Y., Zhang J., Zhou Z., Liu J., Li X., Zhou J., Du G., Wang L., Chen J.
    J. Bacteriol. 193:6108-6109(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSH-001Imported.

Entry informationi

Entry nameiF9Y470_KETVW
AccessioniPrimary (citable) accession number: F9Y470
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3