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F9VAA5

- F9VAA5_LACGT

UniProt

F9VAA5 - F9VAA5_LACGT

Protein

Thymidine kinase

Gene

tdk

Organism
Lactococcus garvieae (strain ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3) (Enterococcus seriolicida)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLGAR420889:GH14-1556-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:LCGT_1533Imported
    ORF Names:I578_00463Imported, OO3_00078Imported
    OrganismiLactococcus garvieae (strain ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3) (Enterococcus seriolicida)Imported
    Taxonomic identifieri420889 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000008521: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F9VAA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLYFKYGS MNSGKSIEIL KVAHNYEEQG KPVLIMTSSL DTRAGVGIVA    50
    SRIGMSSEAV AIDDTMNVYE YIENLPIRPF CVLIDEAQFL NKQNIYDLAR 100
    VVDDLNVPVM AFGLKNDFRN ELFEGSKYLL LLADKIEEIK TICWYCSKKA 150
    TMVLRMVEGE PVYEGEQLQI GGNESYIPVC RKHYFHPLKK MESNRINEEI 200
    Length:200
    Mass (Da):22,849
    Last modified:October 19, 2011 - v1
    Checksum:i824133F4C51D6F98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009332 Genomic DNA. Translation: BAK59046.1.
    AHYM01000002 Genomic DNA. Translation: EOT32891.1.
    ASWT01000006 Genomic DNA. Translation: EOT92930.1.
    RefSeqiYP_004779710.1. NC_015930.1.

    Genome annotation databases

    EnsemblBacteriaiBAK59046; BAK59046; LCGT_1533.
    EOT32891; EOT32891; OO3_00078.
    EOT92930; EOT92930; I578_00463.
    GeneIDi11137631.
    KEGGilgr:LCGT_1533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009332 Genomic DNA. Translation: BAK59046.1 .
    AHYM01000002 Genomic DNA. Translation: EOT32891.1 .
    ASWT01000006 Genomic DNA. Translation: EOT92930.1 .
    RefSeqi YP_004779710.1. NC_015930.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK59046 ; BAK59046 ; LCGT_1533 .
    EOT32891 ; EOT32891 ; OO3_00078 .
    EOT92930 ; EOT92930 ; I578_00463 .
    GeneIDi 11137631.
    KEGGi lgr:LCGT_1533.

    Phylogenomic databases

    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci LGAR420889:GH14-1556-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and comparative analysis of the fish pathogen Lactococcus garvieae."
      Morita H., Toh H., Oshima K., Yoshizaki M., Kawanishi M., Nakaya K., Suzuki T., Miyauchi E., Ishii Y., Tanabe S., Murakami M., Hattori M.
      PLoS ONE 6:E23184-E23184(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49156Imported and ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 49156Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 49156Imported.

    Entry informationi

    Entry nameiF9VAA5_LACGT
    AccessioniPrimary (citable) accession number: F9VAA5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3