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F9VAA5

- F9VAA5_LACGT

UniProt

F9VAA5 - F9VAA5_LACGT

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Protein
Thymidine kinase
Gene
tdk, LCGT_1533, I578_00463, OO3_00078
Organism
Lactococcus garvieae (strain ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3) (Enterococcus seriolicida)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLGAR420889:GH14-1556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:LCGT_1533Imported
ORF Names:I578_00463Imported, OO3_00078Imported
OrganismiLactococcus garvieae (strain ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3) (Enterococcus seriolicida)Imported
Taxonomic identifieri420889 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000008521: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F9VAA5-1 [UniParc]FASTAAdd to Basket

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MAQLYFKYGS MNSGKSIEIL KVAHNYEEQG KPVLIMTSSL DTRAGVGIVA    50
SRIGMSSEAV AIDDTMNVYE YIENLPIRPF CVLIDEAQFL NKQNIYDLAR 100
VVDDLNVPVM AFGLKNDFRN ELFEGSKYLL LLADKIEEIK TICWYCSKKA 150
TMVLRMVEGE PVYEGEQLQI GGNESYIPVC RKHYFHPLKK MESNRINEEI 200
Length:200
Mass (Da):22,849
Last modified:October 19, 2011 - v1
Checksum:i824133F4C51D6F98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009332 Genomic DNA. Translation: BAK59046.1.
AHYM01000002 Genomic DNA. Translation: EOT32891.1.
ASWT01000006 Genomic DNA. Translation: EOT92930.1.
RefSeqiYP_004779710.1. NC_015930.1.

Genome annotation databases

EnsemblBacteriaiBAK59046; BAK59046; LCGT_1533.
EOT32891; EOT32891; OO3_00078.
EOT92930; EOT92930; I578_00463.
GeneIDi11137631.
KEGGilgr:LCGT_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009332 Genomic DNA. Translation: BAK59046.1 .
AHYM01000002 Genomic DNA. Translation: EOT32891.1 .
ASWT01000006 Genomic DNA. Translation: EOT92930.1 .
RefSeqi YP_004779710.1. NC_015930.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK59046 ; BAK59046 ; LCGT_1533 .
EOT32891 ; EOT32891 ; OO3_00078 .
EOT92930 ; EOT92930 ; I578_00463 .
GeneIDi 11137631.
KEGGi lgr:LCGT_1533.

Phylogenomic databases

KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci LGAR420889:GH14-1556-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence and comparative analysis of the fish pathogen Lactococcus garvieae."
    Morita H., Toh H., Oshima K., Yoshizaki M., Kawanishi M., Nakaya K., Suzuki T., Miyauchi E., Ishii Y., Tanabe S., Murakami M., Hattori M.
    PLoS ONE 6:E23184-E23184(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49156Imported and ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 49156Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 49156Imported.

Entry informationi

Entry nameiF9VAA5_LACGT
AccessioniPrimary (citable) accession number: F9VAA5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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