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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-2888-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:lp_3420Imported
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)Imported
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF9UU99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiERQTGID.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

F9UU99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLYGKHNH EAEEYLEPVF GAPSEQHDLP KYRLPKHSLS PREADRLVRD
60 70 80 90 100
ELLDEGNSRL NLATFCQTYM EPEAVELMKD TLAKNAIDKS EYPRTAEIEN
110 120 130 140 150
RCVNIIANLW HAPDDEHFTG TSTIGSSEAC MLGGLAMKFA WRKRAQAAGL
160 170 180 190 200
DLNAHRPNLV ISAGYQVCWE KFCVYWDVDM HVVPMDEQHM ALDVNHVLDY
210 220 230 240 250
VDEYTIGIVG IMGITYTGQY DDLAALDKVV THYNHQHPKL PVYIHVDAAS
260 270 280 290 300
GGFYTPFIEP QLIWDFRLAN VVSINASGHK YGLVYPGVGW VVWRDRQFLP
310 320 330 340 350
PELVFKVSYL GGELPTMAIN FSHSAAQLIG QYYNFIRFGM DGYREIQTKT
360 370 380 390 400
HDVARYLAAA LDKVGEFKMI NNGHQLPLIC YQLASREDRE WTLYDLSDRL
410 420 430 440 450
LMNGWQVPTY PLPANLEQQV IQRIVVRADF GMNMAHDFMD DLTKAVHDLN
460
HAHIVYHHDA APKKYGFTH
Length:469
Mass (Da):53,574
Last modified:October 18, 2011 - v1
Checksum:i1C54E6A1BAF4C3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC80401.1.
RefSeqiWP_011102153.1. NC_004567.2.
YP_004890915.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC80401; CCC80401; lp_3420.
GeneIDi1063739.
KEGGilpl:lp_3420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC80401.1.
RefSeqiWP_011102153.1. NC_004567.2.
YP_004890915.1. NC_004567.2.

3D structure databases

ProteinModelPortaliF9UU99.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC80401; CCC80401; lp_3420.
GeneIDi1063739.
KEGGilpl:lp_3420.

Phylogenomic databases

KOiK01580.
OMAiERQTGID.

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-2888-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1Imported.
  2. "Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome."
    Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M., Kleerebezem M., van Hijum S.A.F.T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WCFS1.

Entry informationi

Entry nameiF9UU99_LACPL
AccessioniPrimary (citable) accession number: F9UU99
Entry historyi
Integrated into UniProtKB/TrEMBL: October 18, 2011
Last sequence update: October 18, 2011
Last modified: March 31, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.