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Protein

Shionone synthase

Gene

SHS1

Organism
Aster tataricus (Tartarian aster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase involved in the production of shionone, a triterpenoid with a rare 6/6/6/6 tetracyclic skeleton and a C-3 carbonyl carbon. Produces also small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = shionone.1 Publication

GO - Molecular functioni

  • oxidosqualene cyclase activity Source: UniProtKB

GO - Biological processi

  • triterpenoid biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Shionone synthase (EC:5.4.99.46)
Short name:
AtaSHS
Gene namesi
Name:SHS1
Synonyms:ZW1
OrganismiAster tataricus (Tartarian aster)
Taxonomic identifieri588669 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAstereaeAustralasian lineagesAster

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004189171 – 761Shionone synthaseAdd BLAST761

Proteomic databases

PRIDEiF8WQD0

Expressioni

Tissue specificityi

Expressed in stems, leaves and flowers. Lower expression in roots, stolons, rhizomes and radical leaves.1 Publication

Structurei

3D structure databases

SMRiF8WQD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 189PFTB 1Add BLAST42
Repeati513 – 555PFTB 2Add BLAST43
Repeati590 – 630PFTB 3Add BLAST41
Repeati639 – 680PFTB 4Add BLAST42

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK21940

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

Sequencei

Sequence statusi: Complete.

F8WQD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLKIADGG NNPYLYSTNN FIGRQTWEFD PNYGTPEERD EVEQARLHFW
60 70 80 90 100
NHRHEIKPSG DTLWRMQFIR EKKFKQTIPQ VKIEDDEEIS YDKVTATMRR
110 120 130 140 150
SVHLLEALLA DDGHWPAENS GPSFFIQPLV MCLYITGHLN SVFPAEHRKE
160 170 180 190 200
ILRYVYSHQN KDGGWGLHME GHSIMFGTTL SYICMRLLGE GPDGGLNGAC
210 220 230 240 250
TRARKWILDH GGAIANPSWG KVWLSILGVH EWVGCNPLPP EFWLFPSFLP
260 270 280 290 300
MSPGKMWSYC RLVFMPMSYL YGRRFVGPIT PLVLQLRKEL YAQPYNDIKW
310 320 330 340 350
KSSRHVCAKE DIYYPHPLLQ DLMWDSLYIL TEPLLTRWPF NKLRKKALAT
360 370 380 390 400
TMRHIHYEDE NSRYITIGSV EKILCMLACW DEDPNGVCFK KHLARIPDYI
410 420 430 440 450
WVAEDGMKMQ TFGSQVWDAS IGIQALLATE LTHDIAPILK KGHEFIKASQ
460 470 480 490 500
VRDNPSGDFK SMYRHISKGS WTFSDQDHGW QLSDCTTIGL TCCLLLSTMP
510 520 530 540 550
PETVGEKMDP EQLKDAVNVI LSLQSENGGL AAWEPAGSSN WLEMLNPIEF
560 570 580 590 600
IEDIVIEHEY VECTGTGMEA LVLFKKLYPK HRTKEVESFL TNAARYLDNT
610 620 630 640 650
QMPDGSWYGE WGICFTYGTY YALGGLAAIE KTYENCQSIR KAVRFLLKTQ
660 670 680 690 700
GEDGGWGESY RSCAEKIYIP LDGNRSTVVH TAWAMLGLMH SKQEERDPIP
710 720 730 740 750
LHRAAKLLIN SQMENGDFPQ QDTTGAFKKN CLLHYPMYRN IYTLWALAQY
760
RKKVLRQPTG I
Length:761
Mass (Da):87,565
Last modified:October 19, 2011 - v1
Checksum:iA8404790E57BBC90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB609123 mRNA Translation: BAK52535.1

Genome annotation databases

KEGGiag:BAK52535

Similar proteinsi

Entry informationi

Entry nameiSHS1_ASTTA
AccessioniPrimary (citable) accession number: F8WQD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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