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F8WQD0

- SHS1_ASTTA

UniProt

F8WQD0 - SHS1_ASTTA

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Protein
Shionone synthase
Gene
SHS1, ZW1
Organism
Aster tataricus (Tartarian aster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase involved in the production of shionone, a triterpenoid with a rare 6/6/6/6 tetracyclic skeleton and a C-3 carbonyl carbon. Produces also small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = shionone.1 Publication

GO - Molecular functioni

  1. oxidosqualene cyclase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. triterpenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Shionone synthase (EC:5.4.99.46)
Short name:
AtaSHS
Gene namesi
Name:SHS1
Synonyms:ZW1
OrganismiAster tataricus (Tartarian aster)
Taxonomic identifieri588669 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAstereaeAustralasian lineagesAster

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Shionone synthase
PRO_0000418917Add
BLAST

Expressioni

Tissue specificityi

Expressed in stems, leaves and flowers. Lower expression in roots, stolons, rhizomes and radical leaves.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1
Add
BLAST
Repeati513 – 55543PFTB 2
Add
BLAST
Repeati590 – 63041PFTB 3
Add
BLAST
Repeati639 – 68042PFTB 4
Add
BLAST

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 3 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WQD0-1 [UniParc]FASTAAdd to Basket

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MWRLKIADGG NNPYLYSTNN FIGRQTWEFD PNYGTPEERD EVEQARLHFW    50
NHRHEIKPSG DTLWRMQFIR EKKFKQTIPQ VKIEDDEEIS YDKVTATMRR 100
SVHLLEALLA DDGHWPAENS GPSFFIQPLV MCLYITGHLN SVFPAEHRKE 150
ILRYVYSHQN KDGGWGLHME GHSIMFGTTL SYICMRLLGE GPDGGLNGAC 200
TRARKWILDH GGAIANPSWG KVWLSILGVH EWVGCNPLPP EFWLFPSFLP 250
MSPGKMWSYC RLVFMPMSYL YGRRFVGPIT PLVLQLRKEL YAQPYNDIKW 300
KSSRHVCAKE DIYYPHPLLQ DLMWDSLYIL TEPLLTRWPF NKLRKKALAT 350
TMRHIHYEDE NSRYITIGSV EKILCMLACW DEDPNGVCFK KHLARIPDYI 400
WVAEDGMKMQ TFGSQVWDAS IGIQALLATE LTHDIAPILK KGHEFIKASQ 450
VRDNPSGDFK SMYRHISKGS WTFSDQDHGW QLSDCTTIGL TCCLLLSTMP 500
PETVGEKMDP EQLKDAVNVI LSLQSENGGL AAWEPAGSSN WLEMLNPIEF 550
IEDIVIEHEY VECTGTGMEA LVLFKKLYPK HRTKEVESFL TNAARYLDNT 600
QMPDGSWYGE WGICFTYGTY YALGGLAAIE KTYENCQSIR KAVRFLLKTQ 650
GEDGGWGESY RSCAEKIYIP LDGNRSTVVH TAWAMLGLMH SKQEERDPIP 700
LHRAAKLLIN SQMENGDFPQ QDTTGAFKKN CLLHYPMYRN IYTLWALAQY 750
RKKVLRQPTG I 761
Length:761
Mass (Da):87,565
Last modified:October 19, 2011 - v1
Checksum:iA8404790E57BBC90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB609123 mRNA. Translation: BAK52535.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB609123 mRNA. Translation: BAK52535.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 3 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus."
    Sawai S., Uchiyama H., Mizuno S., Aoki T., Akashi T., Ayabe S., Takahashi T.
    FEBS Lett. 585:1031-1036(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSHS1_ASTTA
AccessioniPrimary (citable) accession number: F8WQD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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