Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F8WQD0

- SHS1_ASTTA

UniProt

F8WQD0 - SHS1_ASTTA

Protein

Shionone synthase

Gene

SHS1

Organism
Aster tataricus (Tartarian aster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 9 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Oxidosqualene cyclase involved in the production of shionone, a triterpenoid with a rare 6/6/6/6 tetracyclic skeleton and a C-3 carbonyl carbon. Produces also small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = shionone.1 Publication

    GO - Molecular functioni

    1. oxidosqualene cyclase activity Source: UniProtKB

    GO - Biological processi

    1. triterpenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shionone synthase (EC:5.4.99.46)
    Short name:
    AtaSHS
    Gene namesi
    Name:SHS1
    Synonyms:ZW1
    OrganismiAster tataricus (Tartarian aster)
    Taxonomic identifieri588669 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAstereaeAustralasian lineagesAster

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 761761Shionone synthasePRO_0000418917Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in stems, leaves and flowers. Lower expression in roots, stolons, rhizomes and radical leaves.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati148 – 18942PFTB 1Add
    BLAST
    Repeati513 – 55543PFTB 2Add
    BLAST
    Repeati590 – 63041PFTB 3Add
    BLAST
    Repeati639 – 68042PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 3 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8WQD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRLKIADGG NNPYLYSTNN FIGRQTWEFD PNYGTPEERD EVEQARLHFW    50
    NHRHEIKPSG DTLWRMQFIR EKKFKQTIPQ VKIEDDEEIS YDKVTATMRR 100
    SVHLLEALLA DDGHWPAENS GPSFFIQPLV MCLYITGHLN SVFPAEHRKE 150
    ILRYVYSHQN KDGGWGLHME GHSIMFGTTL SYICMRLLGE GPDGGLNGAC 200
    TRARKWILDH GGAIANPSWG KVWLSILGVH EWVGCNPLPP EFWLFPSFLP 250
    MSPGKMWSYC RLVFMPMSYL YGRRFVGPIT PLVLQLRKEL YAQPYNDIKW 300
    KSSRHVCAKE DIYYPHPLLQ DLMWDSLYIL TEPLLTRWPF NKLRKKALAT 350
    TMRHIHYEDE NSRYITIGSV EKILCMLACW DEDPNGVCFK KHLARIPDYI 400
    WVAEDGMKMQ TFGSQVWDAS IGIQALLATE LTHDIAPILK KGHEFIKASQ 450
    VRDNPSGDFK SMYRHISKGS WTFSDQDHGW QLSDCTTIGL TCCLLLSTMP 500
    PETVGEKMDP EQLKDAVNVI LSLQSENGGL AAWEPAGSSN WLEMLNPIEF 550
    IEDIVIEHEY VECTGTGMEA LVLFKKLYPK HRTKEVESFL TNAARYLDNT 600
    QMPDGSWYGE WGICFTYGTY YALGGLAAIE KTYENCQSIR KAVRFLLKTQ 650
    GEDGGWGESY RSCAEKIYIP LDGNRSTVVH TAWAMLGLMH SKQEERDPIP 700
    LHRAAKLLIN SQMENGDFPQ QDTTGAFKKN CLLHYPMYRN IYTLWALAQY 750
    RKKVLRQPTG I 761
    Length:761
    Mass (Da):87,565
    Last modified:October 19, 2011 - v1
    Checksum:iA8404790E57BBC90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB609123 mRNA. Translation: BAK52535.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB609123 mRNA. Translation: BAK52535.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus."
      Sawai S., Uchiyama H., Mizuno S., Aoki T., Akashi T., Ayabe S., Takahashi T.
      FEBS Lett. 585:1031-1036(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSHS1_ASTTA
    AccessioniPrimary (citable) accession number: F8WQD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 9 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3