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F8WJL1

- F8WJL1_MOUSE

UniProt

F8WJL1 - F8WJL1_MOUSE

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Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene
Cacna1c
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. protein binding Source: MGI
  3. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion-dependent exocytosis Source: MGI
  3. calcium ion import Source: RefGenome
  4. calcium ion transport Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1CImported
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. caveolar macromolecular signaling complex Source: MGI
  2. dendritic shaft Source: MGI
  3. membrane Source: MGI
  4. neuronal cell body Source: MGI
  5. plasma membrane Source: MGI
  6. T-tubule Source: MGI
  7. voltage-gated calcium channel complex Source: MGI
  8. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiF8WJL1.
BgeeiF8WJL1.

Structurei

3D structure databases

ProteinModelPortaliF8WJL1.
SMRiF8WJL1. Positions 260-288, 1390-1470.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117620.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WJL1-1 [UniParc]FASTAAdd to Basket

« Hide

ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS 250
KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
KPRNMSMPTS ETESVNTENV AGGDIEGENC GARLAHRISK SKFSRYWRRW 350
NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL TIASEHYNQP HWLTEVQDTA 400
NKALLALFTA EMLLKMYSLG LQAYFVSLFN RFDCFIVCGG ILETILVETK 450
IMSPLGISVL RCVRLLRIFK ITRYWNSLSN LVASLLNSVR SIASLLLLLF 500
LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF DNFPQSLLTV FQILTGEDWN 550
SVMYDGIMAY GGPSFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLADA 600
ESLTSAQKEE EEEKERKKLA RTASPEKKQE VMEKPAVEES KEEKIELKSI 650
TADGESPPTT KINMDDLQPS ENEDKSPHSN PDTAGEEDEE EPEMPVGPRP 700
RPLSELHLKE KAVPMPEASA FFIFSPNNRF RLQCHRIVND TIFTNLILFF 750
ILLSSISLAA EDPVQHTSFR NHILGNADYV FTSIFTLEII LKMTAYGAFL 800
HKGSFCRNYF NILDLLVVSV SLISFGIQSS AINVVKILRV LRVLRPLRAI 850
NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS 900
DSSKQTEAEC KGNYITYKDG EVDHPIIQPR SWENSKFDFD NVLAAMMALF 950
TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR VEISIFFIIY IIIIAFFMMN 1000
IFVGFVIVTF QEQGEQEYKN CELDKNQRQC VEYALKARPL RRYIPKNQHQ 1050
YKVWYVVNST YFEYLMFVLI LLNTICLAMQ HYGQSCLFKI AMNILNMLFT 1100
GLFTVEMILK LIAFKPKHYF CDAWNTFDAL IVVGSIVDIA ITEVHSAEEN 1150
SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML 1200
FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD 1250
IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 1300
FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL 1350
LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL 1400
RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA 1450
TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS 1500
GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ 1550
TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 1600
NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE 1650
SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC 1700
PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP 1750
LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT 1800
LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS 1850
QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT 1900
IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL 1950
GRGRSEEALA DSRSYVSNL 1969
Length:1,969
Mass (Da):221,808
Last modified:September 21, 2011 - v1
Checksum:i142FE4712BBACD77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000112790; ENSMUSP00000108410; ENSMUSG00000051331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8WJL1.
SMRi F8WJL1. Positions 260-288, 1390-1470.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112790 ; ENSMUSP00000108410 ; ENSMUSG00000051331 .

Organism-specific databases

MGIi MGI:103013. Cacna1c.

Phylogenomic databases

GeneTreei ENSGT00750000117620.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 35559948.
SOURCEi Search...

Gene expression databases

ArrayExpressi F8WJL1.
Bgeei F8WJL1.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WJL1_MOUSE
AccessioniPrimary (citable) accession number: F8WJL1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi