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F8WJL1

- F8WJL1_MOUSE

UniProt

F8WJL1 - F8WJL1_MOUSE

Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. high voltage-gated calcium channel activity Source: RefGenome
    2. protein binding Source: MGI
    3. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. calcium ion-dependent exocytosis Source: MGI
    3. calcium ion import Source: RefGenome
    4. calcium ion transport Source: MGI
    5. cellular calcium ion homeostasis Source: MGI
    6. glucose homeostasis Source: MGI
    7. growth hormone secretion Source: MGI
    8. insulin secretion Source: MGI
    9. membrane depolarization during action potential Source: RefGenome
    10. regulation of blood pressure Source: MGI
    11. regulation of organ growth Source: MGI
    12. regulation of vasoconstriction Source: MGI
    13. smooth muscle contraction Source: MGI
    14. smooth muscle contraction involved in micturition Source: MGI
    15. synaptic transmission Source: MGI
    16. visual learning Source: MGI

    Keywords - Molecular functioni

    Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-dependent L-type calcium channel subunit alpha-1CImported
    Gene namesi
    Name:Cacna1cImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:103013. Cacna1c.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. caveolar macromolecular signaling complex Source: MGI
    2. dendritic shaft Source: MGI
    3. membrane Source: MGI
    4. neuronal cell body Source: MGI
    5. plasma membrane Source: MGI
    6. T-tubule Source: MGI
    7. voltage-gated calcium channel complex Source: MGI
    8. Z disc Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiF8WJL1.
    BgeeiF8WJL1.

    Structurei

    3D structure databases

    ProteinModelPortaliF8WJL1.
    SMRiF8WJL1. Positions 1390-1470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117620.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8WJL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
    AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
    SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
    EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
    ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS 250
    KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
    KPRNMSMPTS ETESVNTENV AGGDIEGENC GARLAHRISK SKFSRYWRRW 350
    NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL TIASEHYNQP HWLTEVQDTA 400
    NKALLALFTA EMLLKMYSLG LQAYFVSLFN RFDCFIVCGG ILETILVETK 450
    IMSPLGISVL RCVRLLRIFK ITRYWNSLSN LVASLLNSVR SIASLLLLLF 500
    LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF DNFPQSLLTV FQILTGEDWN 550
    SVMYDGIMAY GGPSFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLADA 600
    ESLTSAQKEE EEEKERKKLA RTASPEKKQE VMEKPAVEES KEEKIELKSI 650
    TADGESPPTT KINMDDLQPS ENEDKSPHSN PDTAGEEDEE EPEMPVGPRP 700
    RPLSELHLKE KAVPMPEASA FFIFSPNNRF RLQCHRIVND TIFTNLILFF 750
    ILLSSISLAA EDPVQHTSFR NHILGNADYV FTSIFTLEII LKMTAYGAFL 800
    HKGSFCRNYF NILDLLVVSV SLISFGIQSS AINVVKILRV LRVLRPLRAI 850
    NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS 900
    DSSKQTEAEC KGNYITYKDG EVDHPIIQPR SWENSKFDFD NVLAAMMALF 950
    TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR VEISIFFIIY IIIIAFFMMN 1000
    IFVGFVIVTF QEQGEQEYKN CELDKNQRQC VEYALKARPL RRYIPKNQHQ 1050
    YKVWYVVNST YFEYLMFVLI LLNTICLAMQ HYGQSCLFKI AMNILNMLFT 1100
    GLFTVEMILK LIAFKPKHYF CDAWNTFDAL IVVGSIVDIA ITEVHSAEEN 1150
    SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML 1200
    FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD 1250
    IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 1300
    FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL 1350
    LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL 1400
    RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA 1450
    TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS 1500
    GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ 1550
    TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 1600
    NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE 1650
    SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC 1700
    PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP 1750
    LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT 1800
    LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS 1850
    QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT 1900
    IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL 1950
    GRGRSEEALA DSRSYVSNL 1969
    Length:1,969
    Mass (Da):221,808
    Last modified:September 21, 2011 - v1
    Checksum:i142FE4712BBACD77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC036121 Genomic DNA. No translation available.
    AC115816 Genomic DNA. No translation available.
    AC126453 Genomic DNA. No translation available.
    AC127328 Genomic DNA. No translation available.
    AC163353 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000112790; ENSMUSP00000108410; ENSMUSG00000051331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC036121 Genomic DNA. No translation available.
    AC115816 Genomic DNA. No translation available.
    AC126453 Genomic DNA. No translation available.
    AC127328 Genomic DNA. No translation available.
    AC163353 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F8WJL1.
    SMRi F8WJL1. Positions 1390-1470.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112790 ; ENSMUSP00000108410 ; ENSMUSG00000051331 .

    Organism-specific databases

    MGIi MGI:103013. Cacna1c.

    Phylogenomic databases

    GeneTreei ENSGT00750000117620.

    Miscellaneous databases

    ChiTaRSi CACNA1C. mouse.
    NextBioi 35559948.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi F8WJL1.
    Bgeei F8WJL1.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF8WJL1_MOUSE
    AccessioniPrimary (citable) accession number: F8WJL1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3