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F8WIW9

- F8WIW9_MOUSE

UniProt

F8WIW9 - F8WIW9_MOUSE

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Protein
Submitted name: Voltage-dependent L-type calcium channel subunit alpha-1C
Gene
Cacna1c
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. protein binding Source: MGI
  3. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion import Source: RefGenome
  3. calcium ion transport Source: MGI
  4. calcium ion-dependent exocytosis Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1CImported
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. T-tubule Source: MGI
  2. Z disc Source: MGI
  3. caveolar macromolecular signaling complex Source: MGI
  4. dendritic shaft Source: MGI
  5. membrane Source: MGI
  6. neuronal cell body Source: MGI
  7. plasma membrane Source: MGI
  8. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiF8WIW9.
BgeeiF8WIW9.

Structurei

3D structure databases

ProteinModelPortaliF8WIW9.
SMRiF8WIW9. Positions 260-288, 1401-1481.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117620.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WIW9-1 [UniParc]FASTAAdd to Basket

« Hide

ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS 250
KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
KPRNMSMPTS ETESVNTENV AGGDIEGENC GARLAHRISK SKFSRYWRRW 350
NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL TIASEHYNQP HWLTEVQDTA 400
NKALLALFTA EMLLKMYSLG LQAYFVSLFN RFDCFIVCGG ILETILVETK 450
IMSPLGISVL RCVRLLRIFK ITRYWNSLSN LVASLLNSVR SIASLLLLLF 500
LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF DNFPQSLLTV FQILTGEDWN 550
SVMYDGIMAY GGPSFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLADA 600
ESLTSAQKEE EEEKERKKLA RTASPEKKQE VMEKPAVEES KEEKIELKSI 650
TADGESPPTT KINMDDLQPS ENEDKSPHSN PDTAGEEDEE EPEMPVGPRP 700
RPLSELHLKE KAVPMPEASA FFIFSPNNRF RLQCHRIVND TIFTNLILFF 750
ILLSSISLAA EDPVQHTSFR NHILGNADYV FTSIFTLEII LKMTAYGAFL 800
HKGSFCRNYF NILDLLVVSV SLISFGIQSS AINVVKILRV LRVLRPLRAI 850
NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS 900
DSSKQTEAEC KGNYITYKDG EVDHPIIQPR SWENSKFDFD NVLAAMMALF 950
TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR VEISIFFIIY IIIIAFFMMN 1000
IFVGFVIVTF QEQGEQEYKN CELDKNQRQC VEYALKARPL RRYIPKNQHQ 1050
YKVWYVVNST YFEYLMFVLI LLNTICLAMQ HYGQSCLFKI AMNILNMLFT 1100
GLFTVEMILK LIAFKPKGYF SDPWNVFDFL IVIGSIIDVI LSETNPAEHT 1150
QCSPSMSAEE NSRISITFFR LFRVMRLVKL LSRGEGIRTL LWTFIKSFQA 1200
LPYVALLIVM LFFIYAVIGM QVFGKIALND TTEINRNNNF QTFPQAVLLL 1250
FRCATGEAWQ DIMLACMPGK KCAPESEPSN STEGETPCGS SFAVFYFISF 1300
YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWAEYDPEAK 1350
GRIKHLDVVT LLRRIQPPLG FGKLCPHRVA CKRLVSMNMP LNSDGTVMFN 1400
ATLFALVRTA LRIKTEGNLE QANEELRAII KKIWKRTSMK LLDQVVPPAG 1450
DDEVTVGKFY ATFLIQEYFR KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH 1500
DIGPEIRRAI SGDLTAEEEL DKAMKEAVSA ASEDDIFRRA GGLFGNHVTY 1550
YQSDSRGNFP QTFATQRPLH INKTGNNQAD TESPSHEKLV DSTFTPSSYS 1600
STGSNANINN ANNTALGRFP HPAGYSSTVS TVEGHGPPLS PAVRVQEAAW 1650
KLSSKRCHSR ESQGATVNQE IFPDETRSVR MSEEAEYCSE PSLLSTDMFS 1700
YQEDEHRQLT CPEEDKREIQ PSPKRSFLRS ASLGRRASFH LECLKRQKDQ 1750
GGDISQKTAL PLHLVHHQAL AVAGLSPLLQ RSHSPTTFPR PCPTPPVTPG 1800
SRGRPLRPIP TLRLEGAESS EKLNSSFPSI HCSSWSEETT ACSGSSSMAR 1850
RARPVSLTVP SQAGAPGRQF HGSASSLVEA VLISEGLGQF AQDPKFIEVT 1900
TQELADACDM TIEEMENAAD NILSGGAQQS PNGTLLPFVN CRDPGQDRAV 1950
APEDESCAYA LGRGRSEEAL ADSRSYVSNL 1980
Length:1,980
Mass (Da):223,002
Last modified:September 21, 2011 - v1
Checksum:i18D27E5DA622F629
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000078320; ENSMUSP00000077433; ENSMUSG00000051331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8WIW9.
SMRi F8WIW9. Positions 260-288, 1401-1481.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078320 ; ENSMUSP00000077433 ; ENSMUSG00000051331 .

Organism-specific databases

MGIi MGI:103013. Cacna1c.

Phylogenomic databases

GeneTreei ENSGT00750000117620.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 35559909.
SOURCEi Search...

Gene expression databases

ArrayExpressi F8WIW9.
Bgeei F8WIW9.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WIW9_MOUSE
AccessioniPrimary (citable) accession number: F8WIW9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi