Mylk4

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Myosin light chain kinase family member 4Imported
Gene namesⁱ	Name:Mylk4Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:3643758. Mylk4.

Subcellular locationⁱ

GO - Cellular componentⁱ

extracellular exosome Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8WIP5.
PaxDbⁱ	F8WIP5.
PeptideAtlas More...PeptideAtlasⁱ	F8WIP5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000044951.
ExpressionAtlasⁱ	F8WIP5. baseline and differential.
Genevisibleⁱ	F8WIP5. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8WIP5.
SMRⁱ	F8WIP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	107 – 362	Protein kinaseInterPro annotationAdd BLAST		256

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0032. Eukaryota. ENOG410XRMJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118877.
KEGG Orthology (KO) More...KOⁱ	K00907.
OMAⁱ	FYTVSKT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G005W.
TreeFamⁱ	TF314166.

Family and domain databases

InterProⁱ	View protein in InterPro IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
PANTHERⁱ	PTHR24347. PTHR24347. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F8WIP5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKVKRLEEI SSCHSSNPLE KVAFFQCMEE VEKVKCFLEE NSGDLDLQSG 
        60         70         80         90        100
DNEAEENVWS NRALDERIIV KGGRTSALTD DIPAPAAPFD HRMVMAKHAS 
       110        120        130        140        150
VDNLYTVSKS EILGGGRFGQ VHKCEEKATG LKLAAKIIKT RGAKDKEDVK 
       160        170        180        190        200
NEISVMNQLD HVNLIQLYDA FESKHDIILV MEYVEGGELF DRIIDENCNL 
       210        220        230        240        250
TELDTILFMK QICEGIRYMH QMYILHLDLK PENILCVNRD AKQIKIIDFG 
       260        270        280        290        300
LARRYKPREK LKVNFGTPEF LAPEVVNYDF VSFSTDMWSV GVITYMLLSG 
       310        320        330        340        350
LSPFLGDNDA ETLTNILACR WDLEDEEFQD ISEEAKEFIS KLLIKEKSWR 
       360        370        380 
ISASEALKHP WLSDHKLHSR LSAQKNCNSG VLNLTTK

Length:387

Mass (Da):44,082

Last modified:September 21, 2011 - v1

Checksum:ⁱB029A686B0A275E4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645808 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001159502.1. NM_001166030.1.
UniGeneⁱ	Mm.60041.

Genome annotation databases

Ensemblⁱ	ENSMUST00000057428; ENSMUSP00000060149; ENSMUSG00000044951.
GeneIDⁱ	238564.
KEGGⁱ	mmu:238564.
UCSC genome browser More...UCSCⁱ	uc011yya.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645808 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001159502.1. NM_001166030.1.
UniGeneⁱ	Mm.60041.

3D structure databases

ProteinModelPortalⁱ	F8WIP5.
SMRⁱ	F8WIP5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8WIP5.
PaxDbⁱ	F8WIP5.
PeptideAtlas More...PeptideAtlasⁱ	F8WIP5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000057428; ENSMUSP00000060149; ENSMUSG00000044951.
GeneIDⁱ	238564.
KEGGⁱ	mmu:238564.
UCSC genome browser More...UCSCⁱ	uc011yya.1. mouse.

Organism-specific databases

CTDⁱ	340156.
MGIⁱ	MGI:3643758. Mylk4.

Phylogenomic databases

eggNOGⁱ	KOG0032. Eukaryota. ENOG410XRMJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118877.
KEGG Orthology (KO) More...KOⁱ	K00907.
OMAⁱ	FYTVSKT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G005W.
TreeFamⁱ	TF314166.

Miscellaneous databases

ChiTaRSⁱ	Mylk4. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000044951.
ExpressionAtlasⁱ	F8WIP5. baseline and differential.
Genevisibleⁱ	F8WIP5. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
PANTHERⁱ	PTHR24347. PTHR24347. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8WIP5_MOUSE
Accessionⁱ	F8WIP5Primary (citable) accession number: F8WIP5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	July 5, 2017
	This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8WIP5 (F8WIP5_MOUSE)

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Myosin light chain kinase family member 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ