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Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. channel activity Source: MGI
  3. extracellular ATP-gated cation channel activity Source: MGI
  4. lipopolysaccharide binding Source: MGI
  5. purinergic nucleotide receptor activity Source: MGI
  6. receptor activity Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. bleb assembly Source: MGI
  3. calcium ion transport Source: MGI
  4. cation transmembrane transport Source: GOC
  5. cation transport Source: MGI
  6. cell morphogenesis Source: MGI
  7. cellular response to extracellular stimulus Source: MGI
  8. cellular response to organic cyclic compound Source: MGI
  9. cell volume homeostasis Source: MGI
  10. ceramide biosynthetic process Source: MGI
  11. collagen metabolic process Source: MGI
  12. cytolysis Source: MGI
  13. defense response to Gram-positive bacterium Source: MGI
  14. extrinsic apoptotic signaling pathway Source: MGI
  15. gene expression Source: MGI
  16. homeostasis of number of cells within a tissue Source: MGI
  17. inflammatory response Source: MGI
  18. membrane budding Source: MGI
  19. membrane depolarization Source: MGI
  20. membrane protein ectodomain proteolysis Source: MGI
  21. mitochondrion organization Source: MGI
  22. multicellular organismal protein catabolic process Source: MGI
  23. NAD transport Source: MGI
  24. negative regulation of bone resorption Source: MGI
  25. negative regulation of MAPK cascade Source: MGI
  26. phagolysosome assembly Source: MGI
  27. phospholipid transfer to membrane Source: MGI
  28. phospholipid translocation Source: MGI
  29. plasma membrane organization Source: MGI
  30. pore complex assembly Source: MGI
  31. positive regulation of apoptotic process Source: MGI
  32. positive regulation of bone mineralization Source: MGI
  33. positive regulation of calcium ion transport into cytosol Source: MGI
  34. positive regulation of catalytic activity Source: MGI
  35. positive regulation of cytokine secretion Source: MGI
  36. positive regulation of gamma-aminobutyric acid secretion Source: MGI
  37. positive regulation of glutamate secretion Source: MGI
  38. positive regulation of interleukin-1 alpha secretion Source: MGI
  39. positive regulation of interleukin-1 beta production Source: MGI
  40. positive regulation of interleukin-1 beta secretion Source: MGI
  41. positive regulation of interleukin-6 production Source: MGI
  42. positive regulation of lymphocyte apoptotic process Source: MGI
  43. positive regulation of MAPK cascade Source: MGI
  44. positive regulation of mitochondrial depolarization Source: MGI
  45. positive regulation of ossification Source: MGI
  46. positive regulation of prostaglandin secretion Source: MGI
  47. positive regulation of protein phosphorylation Source: MGI
  48. positive regulation of protein secretion Source: MGI
  49. positive regulation of T cell mediated cytotoxicity Source: MGI
  50. programmed cell death Source: MGI
  51. protein oligomerization Source: MGI
  52. protein phosphorylation Source: MGI
  53. protein processing Source: MGI
  54. purinergic nucleotide receptor signaling pathway Source: MGI
  55. reactive oxygen species metabolic process Source: MGI
  56. release of sequestered calcium ion into cytosol Source: MGI
  57. response to ATP Source: MGI
  58. response to bacterium Source: MGI
  59. response to calcium ion Source: MGI
  60. response to drug Source: MGI
  61. response to electrical stimulus Source: MGI
  62. response to fluid shear stress Source: MGI
  63. response to lipopolysaccharide Source: MGI
  64. response to mechanical stimulus Source: MGI
  65. response to organic cyclic compound Source: MGI
  66. response to organic substance Source: MGI
  67. response to zinc ion Source: MGI
  68. skeletal system morphogenesis Source: MGI
  69. synaptic vesicle exocytosis Source: MGI
  70. T cell homeostasis Source: MGI
  71. T cell proliferation Source: MGI
  72. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

  1. Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of nuclear inner membrane Source: GO_Central
  4. integral component of plasma membrane Source: MGI
  5. membrane Source: MGI
  6. neuromuscular junction Source: MGI
  7. neuronal cell body Source: MGI
  8. plasma membrane Source: MGI
  9. synapse Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8WI93.

Expressioni

Gene expression databases

BgeeiF8WI93.
ExpressionAtlasiF8WI93. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93. Positions 35-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016028.
KOiK05220.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WI93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG
210 220 230 240 250
HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG
260 270 280 290 300
IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC
360 370 380 390 400
IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY
410 420 430 440
VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP VRVLCLHVCM RT
Length:442
Mass (Da):50,679
Last modified:September 21, 2011 - v1
Checksum:iC7B6166B3231AE16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
KEGGimmu:18439.
UCSCiuc008zlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93. Positions 35-355.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiF8WI93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
KEGGimmu:18439.
UCSCiuc008zlr.1. mouse.

Organism-specific databases

CTDi5027.
MGIiMGI:1339957. P2rx7.

Phylogenomic databases

GeneTreeiENSGT00390000016028.
KOiK05220.

Miscellaneous databases

NextBioi294114.
SOURCEiSearch...

Gene expression databases

BgeeiF8WI93.
ExpressionAtlasiF8WI93. baseline and differential.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WI93_MOUSE
AccessioniPrimary (citable) accession number: F8WI93
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 29, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.