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Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: MGI
  • channel activity Source: MGI
  • extracellular ATP-gated cation channel activity Source: MGI
  • lipopolysaccharide binding Source: MGI
  • purinergic nucleotide receptor activity Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • bleb assembly Source: MGI
  • calcium ion transport Source: MGI
  • cation transport Source: MGI
  • cell morphogenesis Source: MGI
  • cellular response to dsRNA Source: MGI
  • cellular response to extracellular stimulus Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • cell volume homeostasis Source: MGI
  • ceramide biosynthetic process Source: MGI
  • collagen metabolic process Source: MGI
  • cytolysis Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • gene expression Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • inflammatory response Source: MGI
  • membrane budding Source: MGI
  • membrane depolarization Source: MGI
  • membrane protein ectodomain proteolysis Source: MGI
  • mitochondrion organization Source: MGI
  • multicellular organismal protein catabolic process Source: MGI
  • NAD transport Source: MGI
  • negative regulation of bone resorption Source: MGI
  • negative regulation of cell volume Source: MGI
  • negative regulation of MAPK cascade Source: MGI
  • phagolysosome assembly Source: MGI
  • phospholipid scrambling Source: MGI
  • phospholipid transfer to membrane Source: MGI
  • phospholipid translocation Source: MGI
  • plasma membrane organization Source: MGI
  • pore complex assembly Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of bleb assembly Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of calcium ion transport into cytosol Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • positive regulation of cytokine secretion Source: MGI
  • positive regulation of gamma-aminobutyric acid secretion Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of glutamate secretion Source: MGI
  • positive regulation of glycolytic process Source: MGI
  • positive regulation of interleukin-1 alpha secretion Source: MGI
  • positive regulation of interleukin-1 beta production Source: MGI
  • positive regulation of interleukin-1 beta secretion Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of ion transmembrane transport Source: MGI
  • positive regulation of lymphocyte apoptotic process Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of mitochondrial depolarization Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of prostaglandin secretion Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of protein secretion Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI
  • programmed cell death Source: MGI
  • protein oligomerization Source: MGI
  • protein phosphorylation Source: MGI
  • protein processing Source: MGI
  • purinergic nucleotide receptor signaling pathway Source: MGI
  • reactive oxygen species metabolic process Source: MGI
  • release of sequestered calcium ion into cytosol Source: MGI
  • response to ATP Source: MGI
  • response to bacterium Source: MGI
  • response to calcium ion Source: MGI
  • response to drug Source: MGI
  • response to electrical stimulus Source: MGI
  • response to fluid shear stress Source: MGI
  • response to lipopolysaccharide Source: MGI
  • response to mechanical stimulus Source: MGI
  • response to organic cyclic compound Source: MGI
  • response to organic substance Source: MGI
  • response to zinc ion Source: MGI
  • skeletal system morphogenesis Source: MGI
  • synaptic vesicle exocytosis Source: MGI
  • T cell homeostasis Source: MGI
  • T cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of nuclear inner membrane Source: GO_Central
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • neuromuscular junction Source: MGI
  • neuronal cell body Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8WI93.

Expressioni

Gene expression databases

BgeeiF8WI93.
ExpressionAtlasiF8WI93. baseline and differential.
GenevisibleiF8WI93. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Structurei

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93. Positions 35-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016028.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WI93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG
210 220 230 240 250
HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG
260 270 280 290 300
IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC
360 370 380 390 400
IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY
410 420 430 440
VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP VRVLCLHVCM RT
Length:442
Mass (Da):50,679
Last modified:September 21, 2011 - v1
Checksum:iC7B6166B3231AE16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
UCSCiuc008zlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93. Positions 35-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Proteomic databases

PRIDEiF8WI93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
UCSCiuc008zlr.1. mouse.

Organism-specific databases

CTDi5027.
MGIiMGI:1339957. P2rx7.

Phylogenomic databases

GeneTreeiENSGT00390000016028.

Miscellaneous databases

NextBioi294114.
SOURCEiSearch...

Gene expression databases

BgeeiF8WI93.
ExpressionAtlasiF8WI93. baseline and differential.
GenevisibleiF8WI93. MM.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WI93_MOUSE
AccessioniPrimary (citable) accession number: F8WI93
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 22, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.