P2X purinoceptor - Mus musculus (Mouse)

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F8WI93 (F8WI93_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 18. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
P2X purinoceptor RuleBase RU000681

Gene names

Name:

P2rx7 Ensembl ENSMUSP00000031425 MGI 1339957

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000031425

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homo- or heteropolymers By similarity. RuleBase RU000681
Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU000681.
Sequence similarities	Belongs to the P2X receptor family. RuleBase RU000681
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000031425

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000681
Molecular function	Ion channel RuleBase RU000681 Receptor RuleBase RU000681
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD transport Inferred from mutant phenotype PubMed 17803959. Source: MGI T cell homeostasis Inferred from mutant phenotype PubMed 16116196. Source: MGI T cell proliferation Inferred from mutant phenotype PubMed 15914561. Source: MGI activation of MAPK activity Inferred from mutant phenotype PubMed 17306762. Source: MGI bleb assembly Inferred from mutant phenotype PubMed 17135244. Source: MGI cell morphogenesis Inferred from mutant phenotype PubMed 12055263. Source: MGI cell volume homeostasis Inferred from direct assay PubMed 18097031. Source: MGI cellular response to extracellular stimulus Inferred from mutant phenotype PubMed 18082965. Source: MGI ceramide biosynthetic process Inferred from direct assay PubMed 16325464. Source: MGI collagen metabolic process Inferred from mutant phenotype PubMed 16969386. Source: MGI cytolysis Inferred from direct assay PubMed 16116196 PubMed 18097031. Source: MGI defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 11544318. Source: MGI homeostasis of number of cells within a tissue Inferred from mutant phenotype PubMed 16969386. Source: MGI inflammatory response Inferred from mutant phenotype PubMed 12055263 PubMed 16969386. Source: MGI membrane budding Inferred from mutant phenotype PubMed 15905573. Source: MGI membrane protein ectodomain proteolysis Inferred from mutant phenotype PubMed 17286969. Source: MGI mitochondrion organization Inferred from direct assay PubMed 16325464. Source: MGI multicellular organismal protein catabolic process Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of MAPK cascade Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of bone resorption Inferred from mutant phenotype PubMed 12677010. Source: MGI phagolysosome assembly Inferred from mutant phenotype PubMed 11544318. Source: MGI phospholipid transfer to membrane Inferred from mutant phenotype PubMed 12370338. Source: MGI phospholipid translocation Inferred from direct assay PubMed 18097031. Source: MGI plasma membrane organization Inferred from direct assay PubMed 18097031. Source: MGI pore complex assembly Inferred from mutant phenotype PubMed 12370338 PubMed 15937334 PubMed 16269410. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 14761980. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 16325464 PubMed 16493071 PubMed 16969386. Source: MGI positive regulation of bone mineralization Inferred from mutant phenotype PubMed 12677010 PubMed 18519738. Source: MGI positive regulation of gamma-aminobutyric acid secretion Inferred from mutant phenotype PubMed 15640761. Source: MGI positive regulation of glutamate secretion Inferred from mutant phenotype PubMed 15640761 PubMed 17306762. Source: MGI positive regulation of interleukin-1 alpha secretion Inferred from mutant phenotype PubMed 18490713. Source: MGI positive regulation of interleukin-1 beta secretion Inferred from mutant phenotype PubMed 11016935 PubMed 15905573 PubMed 18490713. Source: MGI positive regulation of interleukin-6 production Inferred from mutant phenotype PubMed 11016935. Source: MGI positive regulation of mitochondrial depolarization Inferred from mutant phenotype PubMed 16198349. Source: MGI positive regulation of prostaglandin secretion Inferred from mutant phenotype PubMed 16269410. Source: MGI protein oligomerization Inferred from direct assay PubMed 15713258. Source: MGI protein processing Inferred from mutant phenotype PubMed 11016935. Source: MGI reactive oxygen species metabolic process Inferred from mutant phenotype PubMed 17448897. Source: MGI release of sequestered calcium ion into cytosol Inferred from mutant phenotype PubMed 18082965. Source: MGI response to ATP Inferred from direct assay PubMed 15240711 PubMed 15713258. Source: MGI response to calcium ion Inferred from direct assay PubMed 15240711. Source: MGI response to drug Inferred from mutant phenotype PubMed 18082965. Source: MGI response to electrical stimulus Inferred from mutant phenotype PubMed 15640761. Source: MGI response to fluid shear stress Inferred from mutant phenotype PubMed 16269410. Source: MGI response to lipopolysaccharide Inferred from direct assay PubMed 15240711. Source: MGI response to mechanical stimulus Inferred from mutant phenotype PubMed 16269410. Source: MGI response to zinc ion Inferred from mutant phenotype PubMed 15978588 PubMed 18082965. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 18519738. Source: MGI synaptic vesicle exocytosis Inferred from mutant phenotype PubMed 15713258. Source: MGI
Cellular_component	cell-cell junction Inferred from direct assay PubMed 15331634. Source: MGI external side of plasma membrane Inferred from direct assay PubMed 17286969. Source: MGI integral to plasma membrane Inferred from mutant phenotype PubMed 12677010. Source: MGI neuromuscular junction Inferred from direct assay PubMed 15713258. Source: MGI neuronal cell body Inferred from direct assay PubMed 15964665 PubMed 15978588. Source: MGI
Molecular_function	ATP binding Inferred from mutant phenotype PubMed 12677010. Source: MGI extracellular ATP-gated cation channel activity Inferred from mutant phenotype PubMed 12677010 PubMed 15713258. Source: MGI lipopolysaccharide binding Inferred from direct assay PubMed 11489964. Source: MGI purinergic nucleotide receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

F8WI93 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: C7B6166B3231AE16
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FASTA

442

50,679

        10         20         30         40         50         60 
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 

        70         80         90        100        110        120 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 

       130        140        150        160        170        180 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 

       190        200        210        220        230        240 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 

       250        260        270        280        290        300 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 

       310        320        330        340        350        360 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 

       370        380        390        400        410        420 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 

       430        440 
LQVVKGQEVP VRVLCLHVCM RT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000031425.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000031425.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC114632 Genomic DNA. No translation available.
IPI	IPI00720028.
RefSeq	NP_001033934.1. NM_001038845.2.
UniGene	Mm.42026.
3D structure databases
ProteinModelPortal	F8WI93.
SMR	F8WI93. Positions 35-355.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneID	18439.
KEGG	mmu:18439.
Organism-specific databases
CTD	5027.
MGI	MGI:1339957. P2rx7.
Phylogenomic databases
GeneTree	ENSGT00390000016028.
KO	K05220.
Gene expression databases
ArrayExpress	F8WI93.
Bgee	F8WI93.
Family and domain databases
Gene3D	2.60.490.10. 1 hit.
InterPro	IPR003050. P2X7_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. PTHR10125. 1 hit. PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01314. P2X7RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294114.
SOURCE	Search...

Entry information

Entry name

F8WI93_MOUSE

Accession

Primary (citable) accession number: F8WI93

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information