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Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiF8WI93.
PaxDbiF8WI93.
PeptideAtlasiF8WI93.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029468.
ExpressionAtlasiF8WI93. baseline and differential.
GenevisibleiF8WI93. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Structurei

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IK4U. Eukaryota.
ENOG4110DDY. LUCA.
GeneTreeiENSGT00390000016028.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 2 hits.
PTHR10125:SF13. PTHR10125:SF13. 2 hits.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WI93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG
210 220 230 240 250
HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG
260 270 280 290 300
IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC
360 370 380 390 400
IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY
410 420 430 440
VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP VRVLCLHVCM RT
Length:442
Mass (Da):50,679
Last modified:September 21, 2011 - v1
Checksum:iC7B6166B3231AE16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
UCSCiuc008zlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
RefSeqiNP_001033934.1. NM_001038845.2.
UniGeneiMm.42026.

3D structure databases

ProteinModelPortaliF8WI93.
SMRiF8WI93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Proteomic databases

MaxQBiF8WI93.
PaxDbiF8WI93.
PeptideAtlasiF8WI93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031425; ENSMUSP00000031425; ENSMUSG00000029468.
GeneIDi18439.
UCSCiuc008zlr.1. mouse.

Organism-specific databases

CTDi5027.
MGIiMGI:1339957. P2rx7.

Phylogenomic databases

eggNOGiENOG410IK4U. Eukaryota.
ENOG4110DDY. LUCA.
GeneTreeiENSGT00390000016028.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029468.
ExpressionAtlasiF8WI93. baseline and differential.
GenevisibleiF8WI93. MM.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 2 hits.
PTHR10125:SF13. PTHR10125:SF13. 2 hits.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF8WI93_MOUSE
AccessioniPrimary (citable) accession number: F8WI93
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.