ID   F8WH42_MOUSE            Unreviewed;       158 AA.
AC   F8WH42;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
GN   Name=Lif {ECO:0000313|Ensembl:ENSMUSP00000036853.4,
GN   ECO:0000313|MGI:MGI:96787};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000036853.4, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000036853.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036853.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000036853.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036853.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC       leukemic cells. Its activities include the induction of hematopoietic
CC       differentiation in normal and myeloid leukemia cells, the induction of
CC       neuronal cell differentiation, and the stimulation of acute-phase
CC       protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the LIF/OSM family.
CC       {ECO:0000256|ARBA:ARBA00005971}.
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DR   RefSeq; NP_001034626.1; NM_001039537.2.
DR   RefSeq; XP_006514607.1; XM_006514544.3.
DR   AlphaFoldDB; F8WH42; -.
DR   SMR; F8WH42; -.
DR   EPD; F8WH42; -.
DR   ProteomicsDB; 351346; -.
DR   Antibodypedia; 10647; 641 antibodies from 45 providers.
DR   DNASU; 16878; -.
DR   Ensembl; ENSMUST00000040750.4; ENSMUSP00000036853.4; ENSMUSG00000034394.15.
DR   GeneID; 16878; -.
DR   AGR; MGI:96787; -.
DR   CTD; 3976; -.
DR   MGI; MGI:96787; Lif.
DR   VEuPathDB; HostDB:ENSMUSG00000034394; -.
DR   GeneTree; ENSGT00390000000059; -.
DR   OMA; CKHYNIF; -.
DR   OrthoDB; 5301125at2759; -.
DR   BioGRID-ORCS; 16878; 5 hits in 78 CRISPR screens.
DR   ChiTaRS; Lifr; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000034394; Expressed in endometrium and 47 other cell types or tissues.
DR   ExpressionAtlas; F8WH42; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0010646; P:regulation of cell communication; IEA:UniProt.
DR   GO; GO:0023051; P:regulation of signaling; IEA:UniProt.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003624; Leukemia_IF.
DR   InterPro; IPR001581; Leukemia_IF/oncostatin.
DR   InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR   PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR   PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR   Pfam; PF01291; LIF_OSM; 1.
DR   PRINTS; PR01883; LEUKAEMIAIF.
DR   SMART; SM00080; LIF_OSM; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00590; LIF_OSM; 1.
DR   Genevisible; F8WH42; MM.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Proteomics identification {ECO:0007829|EPD:F8WH42};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ   SEQUENCE   158 AA;  17574 MW;  DD867142A62F322E CRC64;
     MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG NGTEKTKLVE
     LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM RGLLSNVLCR LCNKYRVGHV
     DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV ISVVVQAF
//