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F8WH42

- F8WH42_MOUSE

UniProt

F8WH42 - F8WH42_MOUSE

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Protein
Submitted name:

Leukemia inhibitory factor

Gene
Lif
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI
  3. leukemia inhibitory factor receptor binding Source: MGI
  4. RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl

GO - Biological processi

  1. blood vessel remodeling Source: MGI
  2. decidualization Source: MGI
  3. embryo implantation Source: MGI
  4. immune response Source: InterPro
  5. leukemia inhibitory factor signaling pathway Source: Ensembl
  6. lung alveolus development Source: MGI
  7. lung development Source: MGI
  8. lung lobe morphogenesis Source: MGI
  9. lung vasculature development Source: MGI
  10. maternal process involved in female pregnancy Source: MGI
  11. muscle organ morphogenesis Source: MGI
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of ERK1 and ERK2 cascade Source: MGI
  14. negative regulation of hormone secretion Source: Ensembl
  15. negative regulation of meiosis Source: MGI
  16. neuron development Source: MGI
  17. positive regulation of astrocyte differentiation Source: MGI
  18. positive regulation of cell proliferation Source: MGI
  19. positive regulation of histone H3-K27 acetylation Source: Ensembl
  20. positive regulation of macrophage differentiation Source: Ensembl
  21. positive regulation of MAPK cascade Source: Ensembl
  22. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  23. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  24. positive regulation of protein localization to nucleus Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  26. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  27. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  28. regulation of cell differentiation Source: MGI
  29. regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  30. spongiotrophoblast differentiation Source: MGI
  31. stem cell differentiation Source: MGI
  32. stem cell maintenance Source: MGI
  33. trophoblast giant cell differentiation Source: MGI
  34. tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96787. Lif.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF8WH42.

Structurei

3D structure databases

ProteinModelPortaliF8WH42.
SMRiF8WH42. Positions 1-158.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WH42-1 [UniParc]FASTAAdd to Basket

« Hide

MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG    50
NGTEKTKLVE LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM 100
RGLLSNVLCR LCNKYRVGHV DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV 150
ISVVVQAF 158
Length:158
Mass (Da):17,574
Last modified:September 21, 2011 - v1
Checksum:iDD867142A62F322E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGeneiMm.4964.

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqi NP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGenei Mm.4964.

3D structure databases

ProteinModelPortali F8WH42.
SMRi F8WH42. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 16878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040750 ; ENSMUSP00000036853 ; ENSMUSG00000034394 .
GeneIDi 16878.
KEGGi mmu:16878.

Organism-specific databases

CTDi 3976.
MGIi MGI:96787. Lif.

Phylogenomic databases

GeneTreei ENSGT00390000000059.
KOi K05419.

Miscellaneous databases

NextBioi 290872.
SOURCEi Search...

Gene expression databases

Bgeei F8WH42.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view ]
PANTHERi PTHR10633. PTHR10633. 1 hit.
Pfami PF01291. LIF_OSM. 1 hit.
[Graphical view ]
PRINTSi PR01883. LEUKAEMIAIF.
SMARTi SM00080. LIF_OSM. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00590. LIF_OSM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WH42_MOUSE
AccessioniPrimary (citable) accession number: F8WH42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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