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F8WH42 (F8WH42_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000036853

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood vessel remodeling

Inferred from genetic interaction PubMed 16691571. Source: MGI

decidualization

Inferred from direct assay PubMed 1522892. Source: MGI

embryo implantation

Inferred from direct assay PubMed 1522892. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

leukemia inhibitory factor signaling pathway

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from genetic interaction PubMed 16691571. Source: MGI

lung lobe morphogenesis

Inferred from genetic interaction PubMed 16691571. Source: MGI

lung vasculature development

Inferred from genetic interaction PubMed 16691571. Source: MGI

muscle organ morphogenesis

Inferred from mutant phenotype PubMed 15716414. Source: MGI

negative regulation of ERK1 and ERK2 cascade

Inferred from genetic interaction PubMed 16691571. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 16691571. Source: MGI

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of meiosis

Inferred from direct assay PubMed 11203703. Source: MGI

neuron development

Inferred from genetic interaction PubMed 15716414. Source: MGI

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of astrocyte differentiation

Inferred from direct assay PubMed 10486560. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 1522892. Source: MGI

positive regulation of histone H3-K27 acetylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein localization to nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16691571. Source: MGI

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

spongiotrophoblast differentiation

Inferred from genetic interaction PubMed 16258063. Source: MGI

stem cell maintenance

Inferred from direct assay PubMed 15358627. Source: MGI

transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: GOC

trophoblast giant cell differentiation

Inferred from genetic interaction PubMed 16258063. Source: MGI

tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 15012602. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA polymerase II transcription factor recruiting transcription factor activity

Inferred from electronic annotation. Source: Ensembl

cytokine activity

Inferred from direct assay PubMed 15012602PubMed 1522892. Source: MGI

growth factor activity

Inferred from mutant phenotype PubMed 1522892. Source: MGI

leukemia inhibitory factor receptor binding

Inferred from sequence orthology PubMed 7957045. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F8WH42 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: DD867142A62F322E

FASTA15817,574
        10         20         30         40         50         60 
MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG NGTEKTKLVE 

        70         80         90        100        110        120 
LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM RGLLSNVLCR LCNKYRVGHV 

       130        140        150 
DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV ISVVVQAF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL731658 Genomic DNA. No translation available.
RefSeqNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGeneMm.4964.

3D structure databases

ProteinModelPortalF8WH42.
SMRF8WH42. Positions 1-158.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU16878.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneID16878.
KEGGmmu:16878.

Organism-specific databases

CTD3976.
MGIMGI:96787. Lif.

Phylogenomic databases

GeneTreeENSGT00390000000059.
KOK05419.

Gene expression databases

ArrayExpressF8WH42.
BgeeF8WH42.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERPTHR10633. PTHR10633. 1 hit.
PfamPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSPR01883. LEUKAEMIAIF.
SMARTSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290872.
SOURCESearch...

Entry information

Entry nameF8WH42_MOUSE
AccessionPrimary (citable) accession number: F8WH42
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)