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Protein
Submitted name:

Leukemia inhibitory factor

Gene

Lif

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • leukemia inhibitory factor receptor binding Source: MGI
  • receptor binding Source: MGI
  • RNA polymerase II transcription factor recruiting transcription factor activity Source: MGI

GO - Biological processi

  • blood vessel remodeling Source: MGI
  • decidualization Source: MGI
  • embryo implantation Source: MGI
  • immune response Source: InterPro
  • leukemia inhibitory factor signaling pathway Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • lung lobe morphogenesis Source: MGI
  • lung vasculature development Source: MGI
  • maternal process involved in female pregnancy Source: MGI
  • muscle organ morphogenesis Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: MGI
  • negative regulation of hormone secretion Source: MGI
  • negative regulation of meiotic nuclear division Source: MGI
  • neuron development Source: MGI
  • positive regulation of astrocyte differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of histone H3-K27 acetylation Source: MGI
  • positive regulation of macrophage differentiation Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of protein localization to nucleus Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of metanephric nephron tubule epithelial cell differentiation Source: MGI
  • regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • stem cell differentiation Source: MGI
  • stem cell maintenance Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
  • trophoblast giant cell differentiation Source: MGI
  • tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96787. Lif.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF8WH42.
ExpressionAtlasiF8WH42. baseline and differential.
GenevisibleiF8WH42. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067066.

Structurei

3D structure databases

ProteinModelPortaliF8WH42.
SMRiF8WH42. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WH42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG
60 70 80 90 100
NGTEKTKLVE LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM
110 120 130 140 150
RGLLSNVLCR LCNKYRVGHV DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV

ISVVVQAF
Length:158
Mass (Da):17,574
Last modified:September 21, 2011 - v1
Checksum:iDD867142A62F322E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.2.
UniGeneiMm.4964.

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.2.
UniGeneiMm.4964.

3D structure databases

ProteinModelPortaliF8WH42.
SMRiF8WH42. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067066.

Protocols and materials databases

DNASUi16878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Organism-specific databases

CTDi3976.
MGIiMGI:96787. Lif.

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Miscellaneous databases

NextBioi290872.
SOURCEiSearch...

Gene expression databases

BgeeiF8WH42.
ExpressionAtlasiF8WH42. baseline and differential.
GenevisibleiF8WH42. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WH42_MOUSE
AccessioniPrimary (citable) accession number: F8WH42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.