Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Leukemia inhibitory factor

Gene

Lif

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI
  3. leukemia inhibitory factor receptor binding Source: MGI
  4. receptor binding Source: MGI
  5. RNA polymerase II transcription factor recruiting transcription factor activity Source: MGI

GO - Biological processi

  1. blood vessel remodeling Source: MGI
  2. decidualization Source: MGI
  3. embryo implantation Source: MGI
  4. immune response Source: InterPro
  5. leukemia inhibitory factor signaling pathway Source: MGI
  6. lung alveolus development Source: MGI
  7. lung development Source: MGI
  8. lung lobe morphogenesis Source: MGI
  9. lung vasculature development Source: MGI
  10. maternal process involved in female pregnancy Source: MGI
  11. muscle organ morphogenesis Source: MGI
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of ERK1 and ERK2 cascade Source: MGI
  14. negative regulation of hormone secretion Source: MGI
  15. negative regulation of meiosis Source: MGI
  16. neuron development Source: MGI
  17. positive regulation of astrocyte differentiation Source: MGI
  18. positive regulation of cell proliferation Source: MGI
  19. positive regulation of histone H3-K27 acetylation Source: MGI
  20. positive regulation of macrophage differentiation Source: MGI
  21. positive regulation of MAPK cascade Source: MGI
  22. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: MGI
  23. positive regulation of peptidyl-serine phosphorylation Source: MGI
  24. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  25. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  26. positive regulation of protein localization to nucleus Source: MGI
  27. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  28. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  29. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  30. regulation of cell differentiation Source: MGI
  31. regulation of metanephric nephron tubule epithelial cell differentiation Source: MGI
  32. regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  33. spongiotrophoblast differentiation Source: MGI
  34. stem cell differentiation Source: MGI
  35. stem cell maintenance Source: MGI
  36. transcription from RNA polymerase II promoter Source: MGI
  37. trophoblast giant cell differentiation Source: MGI
  38. tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96787. Lif.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF8WH42.
ExpressionAtlasiF8WH42. baseline and differential.

Structurei

3D structure databases

SMRiF8WH42. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WH42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG
60 70 80 90 100
NGTEKTKLVE LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM
110 120 130 140 150
RGLLSNVLCR LCNKYRVGHV DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV

ISVVVQAF
Length:158
Mass (Da):17,574
Last modified:September 21, 2011 - v1
Checksum:iDD867142A62F322E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGeneiMm.4964.

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGeneiMm.4964.

3D structure databases

SMRiF8WH42. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi16878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Organism-specific databases

CTDi3976.
MGIiMGI:96787. Lif.

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Miscellaneous databases

NextBioi290872.
SOURCEiSearch...

Gene expression databases

BgeeiF8WH42.
ExpressionAtlasiF8WH42. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WH42_MOUSE
AccessioniPrimary (citable) accession number: F8WH42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.