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F8WH42

- F8WH42_MOUSE

UniProt

F8WH42 - F8WH42_MOUSE

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Protein
Submitted name:

Leukemia inhibitory factor

Gene

Lif

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI
  3. leukemia inhibitory factor receptor binding Source: MGI
  4. RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl

GO - Biological processi

  1. blood vessel remodeling Source: MGI
  2. decidualization Source: MGI
  3. embryo implantation Source: MGI
  4. immune response Source: InterPro
  5. leukemia inhibitory factor signaling pathway Source: Ensembl
  6. lung alveolus development Source: MGI
  7. lung development Source: MGI
  8. lung lobe morphogenesis Source: MGI
  9. lung vasculature development Source: MGI
  10. maternal process involved in female pregnancy Source: MGI
  11. muscle organ morphogenesis Source: MGI
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of ERK1 and ERK2 cascade Source: MGI
  14. negative regulation of hormone secretion Source: Ensembl
  15. negative regulation of meiosis Source: MGI
  16. neuron development Source: MGI
  17. positive regulation of astrocyte differentiation Source: MGI
  18. positive regulation of cell proliferation Source: MGI
  19. positive regulation of histone H3-K27 acetylation Source: Ensembl
  20. positive regulation of macrophage differentiation Source: Ensembl
  21. positive regulation of MAPK cascade Source: Ensembl
  22. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  23. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  24. positive regulation of protein localization to nucleus Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  26. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  27. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  28. regulation of cell differentiation Source: MGI
  29. regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  30. regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  31. spongiotrophoblast differentiation Source: MGI
  32. stem cell differentiation Source: MGI
  33. stem cell maintenance Source: MGI
  34. trophoblast giant cell differentiation Source: MGI
  35. tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemia inhibitory factorImported
Gene namesi
Name:LifImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96787. Lif.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF8WH42.
ExpressionAtlasiF8WH42. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF8WH42.
SMRiF8WH42. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000000059.
KOiK05419.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PANTHERiPTHR10633. PTHR10633. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
PRINTSiPR01883. LEUKAEMIAIF.
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WH42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG
60 70 80 90 100
NGTEKTKLVE LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM
110 120 130 140 150
RGLLSNVLCR LCNKYRVGHV DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV

ISVVVQAF
Length:158
Mass (Da):17,574
Last modified:September 21, 2011 - v1
Checksum:iDD867142A62F322E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqiNP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGeneiMm.4964.

Genome annotation databases

EnsembliENSMUST00000040750; ENSMUSP00000036853; ENSMUSG00000034394.
GeneIDi16878.
KEGGimmu:16878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731658 Genomic DNA. No translation available.
RefSeqi NP_001034626.1. NM_001039537.2.
XP_006514607.1. XM_006514544.1.
XP_006514608.1. XM_006514545.1.
UniGenei Mm.4964.

3D structure databases

ProteinModelPortali F8WH42.
SMRi F8WH42. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 16878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040750 ; ENSMUSP00000036853 ; ENSMUSG00000034394 .
GeneIDi 16878.
KEGGi mmu:16878.

Organism-specific databases

CTDi 3976.
MGIi MGI:96787. Lif.

Phylogenomic databases

GeneTreei ENSGT00390000000059.
KOi K05419.

Miscellaneous databases

NextBioi 290872.
SOURCEi Search...

Gene expression databases

Bgeei F8WH42.
ExpressionAtlasi F8WH42. baseline and differential.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003624. Leukemia_IF.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view ]
PANTHERi PTHR10633. PTHR10633. 1 hit.
Pfami PF01291. LIF_OSM. 1 hit.
[Graphical view ]
PRINTSi PR01883. LEUKAEMIAIF.
SMARTi SM00080. LIF_OSM. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00590. LIF_OSM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WH42_MOUSE
AccessioniPrimary (citable) accession number: F8WH42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3