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F8WGN0

- F8WGN0_MOUSE

UniProt

F8WGN0 - F8WGN0_MOUSE

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Protein
Submitted name: Voltage-dependent L-type calcium channel subunit alpha-1C
Gene
Cacna1c
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. protein binding Source: MGI
  3. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion import Source: RefGenome
  3. calcium ion transport Source: MGI
  4. calcium ion-dependent exocytosis Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1CImported
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. T-tubule Source: MGI
  2. Z disc Source: MGI
  3. caveolar macromolecular signaling complex Source: MGI
  4. dendritic shaft Source: MGI
  5. membrane Source: MGI
  6. neuronal cell body Source: MGI
  7. plasma membrane Source: MGI
  8. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiF8WGN0.

Structurei

3D structure databases

ProteinModelPortaliF8WGN0.
SMRiF8WGN0. Positions 3-257, 260-288, 385-674, 757-1031, 1087-1346, 1426-1506.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117620.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WGN0-1 [UniParc]FASTAAdd to Basket

« Hide

ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS 250
KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI 350
EGENCGARLA HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV 400
FLNTLTIASE HYNQPHWLTE VQDTANKALL ALFTAEMLLK MYSLGLQAYF 450
VSLFNRFDCF IVCGGILETI LVETKIMSPL GISVLRCVRL LRIFKITRYW 500
NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG GKFNFDEMQT 550
RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 600
ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP 650
EKKQEVMEKP AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK 700
SPHSNPDTAG EEDEEEPEMP VGPRPRPLSE LHLKEKAVPM PEASAFFIFS 750
PNNRFRLQCH RIVNDTIFTN LILFFILLSS ISLAAEDPVQ HTSFRNHILF 800
YFDIVFTTIF TIEIALKMTA YGAFLHKGSF CRNYFNILDL LVVSVSLISF 850
GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 900
VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP 950
IIQPRSWENS KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP 1000
IYNYRVEISI FFIIYIIIIA FFMMNIFVGF VIVTFQEQGE QEYKNCELDK 1050
NQRQCVEYAL KARPLRRYIP KNQHQYKVWY VVNSTYFEYL MFVLILLNTI 1100
CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK PKGYFSDPWN 1150
VFDFLIVIGS IIDVILSETN PAEHTQCSPS MSAEENSRIS ITFFRLFRVM 1200
RLVKLLSRGE GIRTLLWTFI KSFQALPYVA LLIVMLFFIY AVIGMQVFGK 1250
IALNDTTEIN RNNNFQTFPQ AVLLLFRCAT GEAWQDIMLA CMPGKKCAPE 1300
SEPSNSTEGE TPCGSSFAVF YFISFYMLCA FLIINLFVAV IMDNFDYLTR 1350
DWSILGPHHL DEFKRIWAEY DPEAKGRIKH LDVVTLLRRI QPPLGFGKLC 1400
PHRVACKRLV SMNMPLNSDG TVMFNATLFA LVRTALRIKT EGNLEQANEE 1450
LRAIIKKIWK RTSMKLLDQV VPPAGDDEVT VGKFYATFLI QEYFRKFKKR 1500
KEQGLVGKPS QRNALSLQAG LRTLHDIGPE IRRAISGDLT AEEELDKAMK 1550
EAVSAASEDD IFRRAGGLFG NHVTYYQSDS RGNFPQTFAT QRPLHINKTG 1600
NNQADTESPS HEKLVDSTFT PSSYSSTGSN ANINNANNTA LGRFPHPAGY 1650
SSTVSTVEGH GPPLSPAVRV QEAAWKLSSK RCHSRESQGA TVNQEIFPDE 1700
TRSVRMSEEA EYCSEPSLLS TDMFSYQEDE HRQLTCPEED KREIQPSPKR 1750
SFLRSASLGR RASFHLECLK RQKDQGGDIS QKTALPLHLV HHQALAVAGL 1800
SPLLQRSHSP TTFPRPCPTP PVTPGSRGRP LRPIPTLRLE GAESSEKLNS 1850
SFPSIHCSSW SEETTACSGS SSMARRARPV SLTVPSQAGA PGRQFHGSAS 1900
SLVEAVLISE GLGQFAQDPK FIEVTTQELA DACDMTIEEM ENAADNILSG 1950
GAQQSPNGTL LPFVNCRDPG QDRAVAPEDE SCAYALGRGR SEEALADSRS 2000
YVSNL 2005
Length:2,005
Mass (Da):225,883
Last modified:October 3, 2012 - v2
Checksum:i2E714E0671720F1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000075591; ENSMUSP00000075021; ENSMUSG00000051331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8WGN0.
SMRi F8WGN0. Positions 3-257, 260-288, 385-674, 757-1031, 1087-1346, 1426-1506.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075591 ; ENSMUSP00000075021 ; ENSMUSG00000051331 .

Organism-specific databases

MGIi MGI:103013. Cacna1c.

Phylogenomic databases

GeneTreei ENSGT00750000117620.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 35559765.
SOURCEi Search...

Gene expression databases

ArrayExpressi F8WGN0.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WGN0_MOUSE
AccessioniPrimary (citable) accession number: F8WGN0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi