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F8WGN0 (F8WGN0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Cacna1c Ensembl ENSMUSP00000075021 MGI 103013
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000075021
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2005 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000075021

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS027359
   LigandCalcium
   Molecular functionCalcium channel RuleBase RU003808
Ion channel
Voltage-gated channel RuleBase RU003808 SAAS SAAS027359
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from genetic interaction PubMed 9882694. Source: MGI

calcium ion import

Inferred from Biological aspect of Ancestor. Source: RefGenome

calcium ion transport

Inferred from direct assay PubMed 7635187. Source: MGI

calcium ion-dependent exocytosis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

cellular calcium ion homeostasis

Inferred from mutant phenotype PubMed 15132976. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

growth hormone secretion

Inferred from direct assay PubMed 1385406. Source: MGI

insulin secretion

Inferred from mutant phenotype PubMed 12881419. Source: MGI

membrane depolarization during action potential

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of blood pressure

Inferred from mutant phenotype PubMed 14609949. Source: MGI

regulation of organ growth

Inferred from mutant phenotype PubMed 15132976. Source: MGI

regulation of vasoconstriction

Inferred from mutant phenotype PubMed 14609949. Source: MGI

smooth muscle contraction

Inferred from mutant phenotype PubMed 16636102. Source: MGI

smooth muscle contraction involved in micturition

Inferred from mutant phenotype PubMed 15132976. Source: MGI

synaptic transmission

Inferred from mutant phenotype PubMed 16251435. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 16251435. Source: MGI

   Cellular_componentT-tubule

Traceable author statement PubMed 11784029. Source: MGI

Z disc

Inferred from direct assay PubMed 19383796. Source: MGI

caveolar macromolecular signaling complex

Inferred from direct assay PubMed 16648270. Source: MGI

dendritic shaft

Inferred from direct assay PubMed 15090038. Source: MGI

membrane

Inferred from direct assay PubMed 15132976. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 15090038. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15090038PubMed 7598723. Source: MGI

voltage-gated calcium channel complex

Traceable author statement PubMed 11296258. Source: MGI

   Molecular_functionhigh voltage-gated calcium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction PubMed 16787652. Source: MGI

voltage-gated calcium channel activity

Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F8WGN0 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 2E714E0671720F1E

FASTA2,005225,883
        10         20         30         40         50         60 
ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD 

        70         80         90        100        110        120 
GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI 

       130        140        150        160        170        180 
IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA EEDPSPCALE TGHGRQCQNG TVCKPGWDGP 

       190        200        210        220        230        240 
KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL 

       250        260        270        280        290        300 
VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 

       310        320        330        340        350        360 
KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI EGENCGARLA 

       370        380        390        400        410        420 
HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV FLNTLTIASE HYNQPHWLTE 

       430        440        450        460        470        480 
VQDTANKALL ALFTAEMLLK MYSLGLQAYF VSLFNRFDCF IVCGGILETI LVETKIMSPL 

       490        500        510        520        530        540 
GISVLRCVRL LRIFKITRYW NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG 

       550        560        570        580        590        600 
GKFNFDEMQT RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 

       610        620        630        640        650        660 
ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP EKKQEVMEKP 

       670        680        690        700        710        720 
AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK SPHSNPDTAG EEDEEEPEMP 

       730        740        750        760        770        780 
VGPRPRPLSE LHLKEKAVPM PEASAFFIFS PNNRFRLQCH RIVNDTIFTN LILFFILLSS 

       790        800        810        820        830        840 
ISLAAEDPVQ HTSFRNHILF YFDIVFTTIF TIEIALKMTA YGAFLHKGSF CRNYFNILDL 

       850        860        870        880        890        900 
LVVSVSLISF GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 

       910        920        930        940        950        960 
VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP IIQPRSWENS 

       970        980        990       1000       1010       1020 
KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP IYNYRVEISI FFIIYIIIIA 

      1030       1040       1050       1060       1070       1080 
FFMMNIFVGF VIVTFQEQGE QEYKNCELDK NQRQCVEYAL KARPLRRYIP KNQHQYKVWY 

      1090       1100       1110       1120       1130       1140 
VVNSTYFEYL MFVLILLNTI CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK 

      1150       1160       1170       1180       1190       1200 
PKGYFSDPWN VFDFLIVIGS IIDVILSETN PAEHTQCSPS MSAEENSRIS ITFFRLFRVM 

      1210       1220       1230       1240       1250       1260 
RLVKLLSRGE GIRTLLWTFI KSFQALPYVA LLIVMLFFIY AVIGMQVFGK IALNDTTEIN 

      1270       1280       1290       1300       1310       1320 
RNNNFQTFPQ AVLLLFRCAT GEAWQDIMLA CMPGKKCAPE SEPSNSTEGE TPCGSSFAVF 

      1330       1340       1350       1360       1370       1380 
YFISFYMLCA FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFKRIWAEY DPEAKGRIKH 

      1390       1400       1410       1420       1430       1440 
LDVVTLLRRI QPPLGFGKLC PHRVACKRLV SMNMPLNSDG TVMFNATLFA LVRTALRIKT 

      1450       1460       1470       1480       1490       1500 
EGNLEQANEE LRAIIKKIWK RTSMKLLDQV VPPAGDDEVT VGKFYATFLI QEYFRKFKKR 

      1510       1520       1530       1540       1550       1560 
KEQGLVGKPS QRNALSLQAG LRTLHDIGPE IRRAISGDLT AEEELDKAMK EAVSAASEDD 

      1570       1580       1590       1600       1610       1620 
IFRRAGGLFG NHVTYYQSDS RGNFPQTFAT QRPLHINKTG NNQADTESPS HEKLVDSTFT 

      1630       1640       1650       1660       1670       1680 
PSSYSSTGSN ANINNANNTA LGRFPHPAGY SSTVSTVEGH GPPLSPAVRV QEAAWKLSSK 

      1690       1700       1710       1720       1730       1740 
RCHSRESQGA TVNQEIFPDE TRSVRMSEEA EYCSEPSLLS TDMFSYQEDE HRQLTCPEED 

      1750       1760       1770       1780       1790       1800 
KREIQPSPKR SFLRSASLGR RASFHLECLK RQKDQGGDIS QKTALPLHLV HHQALAVAGL 

      1810       1820       1830       1840       1850       1860 
SPLLQRSHSP TTFPRPCPTP PVTPGSRGRP LRPIPTLRLE GAESSEKLNS SFPSIHCSSW 

      1870       1880       1890       1900       1910       1920 
SEETTACSGS SSMARRARPV SLTVPSQAGA PGRQFHGSAS SLVEAVLISE GLGQFAQDPK 

      1930       1940       1950       1960       1970       1980 
FIEVTTQELA DACDMTIEEM ENAADNILSG GAQQSPNGTL LPFVNCRDPG QDRAVAPEDE 

      1990       2000 
SCAYALGRGR SEEALADSRS YVSNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC036121 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalF8WGN0.
SMRF8WGN0. Positions 3-257, 260-288, 385-674, 757-1031, 1087-1346, 1426-1506.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075591; ENSMUSP00000075021; ENSMUSG00000051331.

Organism-specific databases

MGIMGI:103013. Cacna1c.

Phylogenomic databases

GeneTreeENSGT00750000117620.

Gene expression databases

ArrayExpressF8WGN0.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCACNA1C. mouse.
NextBio35559765.
SOURCESearch...

Entry information

Entry nameF8WGN0_MOUSE
AccessionPrimary (citable) accession number: F8WGN0
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)