F8WGL3 (F8WGL3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cofilin-1 Ensembl ENSMUSP00000112259

Gene names

Name:

Cfl1 Ensembl ENSMUSP00000112259 MGI 101757

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000112259

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 ADF-H domain. SAAS SAAS017904
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000112259

Ontologies

Keywords
Ligand	Actin-binding SAAS SAAS017904
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament depolymerization Inferred from electronic annotation. Source: InterPro actin filament organization Inferred from mutant phenotype PubMed 15606898. Source: MGI cell projection organization Inferred from sequence orthology PubMed 16286931. Source: MGI cytokinesis Inferred from mutant phenotype PubMed 15548599. Source: MGI establishment of cell polarity Inferred from mutant phenotype PubMed 15606898. Source: MGI negative regulation of cell size Inferred from sequence orthology PubMed 16286931. Source: MGI neural crest cell migration Inferred from mutant phenotype PubMed 15649475. Source: MGI neural fold formation Inferred from mutant phenotype PubMed 15649475. Source: MGI positive regulation of actin filament depolymerization Inferred from mutant phenotype PubMed 15548599. Source: MGI protein import into nucleus Inferred from electronic annotation. Source: Compara protein phosphorylation Inferred from direct assay PubMed 17018287. Source: MGI regulation of cell morphogenesis Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from direct assay PubMed 17018287. Source: MGI response to virus Inferred from electronic annotation. Source: Compara
Cellular_component	cortical actin cytoskeleton Inferred from direct assay PubMed 15004221PubMed 15548599. Source: MGI lamellipodium Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8WGL3 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 2B7C3A4FD13F9830	FASTA	227	24,576
	10 20 30 40 50 60 MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 70 80 90 100 110 120 GQTVDDPYTT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPENAP LKSKMIYASS 130 140 150 160 170 180 KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPLSHPA PCLEHLNSPR 190 200 210 220 PALGCCRLPL SCQTGGAGGI PAGGGLSLHP SCQTSLPPPG PSFSLHP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000112259.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000112259.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC126029 Genomic DNA. No translation available.
IPI	IPI00407543.
3D structure databases
ProteinModelPortal	F8WGL3.
SMR	F8WGL3. Positions 1-166.
ModBase	Search...
Proteomic databases
PRIDE	F8WGL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000116560; ENSMUSP00000112259; ENSMUSG00000056201.
Organism-specific databases
MGI	MGI:101757. Cfl1.
Phylogenomic databases
GeneTree	ENSGT00440000033289.
OMA	CQTGGAG.
Gene expression databases
ArrayExpress	F8WGL3.
Bgee	F8WGL3.
Family and domain databases
InterPro	IPR002108. Actin-bd_cofilin/tropomyosin. IPR017904. ADF/Cofilin/Destrin. IPR027234. Cofilin_1/2. [Graphical view]
PANTHER	PTHR11913. PTHR11913. 1 hit. PTHR11913:SF2. PTHR11913:SF2. 1 hit.
Pfam	PF00241. Cofilin_ADF. 1 hit. [Graphical view]
PRINTS	PR00006. COFILIN.
SMART	SM00102. ADF. 1 hit. [Graphical view]
PROSITE	PS51263. ADF_H. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35559761.
SOURCE	Search...

Entry information

Entry name

F8WGL3_MOUSE

Accession

Primary (citable) accession number: F8WGL3

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)