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F8WGL3

- F8WGL3_MOUSE

UniProt

F8WGL3 - F8WGL3_MOUSE

Protein
Submitted name:

Cofilin-1

Gene

Cfl1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. actin filament depolymerization Source: InterPro
    2. actin filament organization Source: MGI
    3. cell projection organization Source: MGI
    4. cellular component movement Source: MGI
    5. establishment of cell polarity Source: MGI
    6. mitotic cytokinesis Source: MGI
    7. negative regulation of cell size Source: MGI
    8. neural crest cell migration Source: MGI
    9. neural fold formation Source: MGI
    10. positive regulation of actin filament depolymerization Source: MGI
    11. protein import into nucleus Source: Ensembl
    12. protein phosphorylation Source: MGI
    13. regulation of cell morphogenesis Source: Ensembl
    14. response to amino acid Source: MGI
    15. response to virus Source: Ensembl

    Keywords - Ligandi

    Actin-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cofilin-1Imported
    Gene namesi
    Name:Cfl1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:101757. Cfl1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cortical actin cytoskeleton Source: MGI
    3. cytoplasm Source: MGI
    4. lamellipodium Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF8WGL3.

    Expressioni

    Gene expression databases

    BgeeiF8WGL3.

    Structurei

    3D structure databases

    ProteinModelPortaliF8WGL3.
    SMRiF8WGL3. Positions 1-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains ADF-H domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00440000033289.
    OMAiPPSCQTG.
    OrthoDBiEOG7353Z9.
    TreeFamiTF328601.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR017904. ADF/Cofilin/Destrin.
    IPR027234. Cofilin_1.
    [Graphical view]
    PANTHERiPTHR11913. PTHR11913. 1 hit.
    PTHR11913:SF17. PTHR11913:SF17. 1 hit.
    PfamiPF00241. Cofilin_ADF. 1 hit.
    [Graphical view]
    PRINTSiPR00006. COFILIN.
    SMARTiSM00102. ADF. 1 hit.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8WGL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE    50
    EGKEILVGDV GQTVDDPYTT FVKMLPDKDC RYALYDATYE TKESKKEDLV 100
    FIFWAPENAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 150
    EKLGGSAVIS LEGKPLSHPA PCLEHLNSPR PALGCCRLPL SCQTGGAGGI 200
    PAGGGLSLHP SCQTSLPPPG PSFSLHP 227
    Length:227
    Mass (Da):24,576
    Last modified:September 21, 2011 - v1
    Checksum:i2B7C3A4FD13F9830
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126029 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000116560; ENSMUSP00000112259; ENSMUSG00000056201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126029 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F8WGL3.
    SMRi F8WGL3. Positions 1-166.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F8WGL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000116560 ; ENSMUSP00000112259 ; ENSMUSG00000056201 .

    Organism-specific databases

    MGIi MGI:101757. Cfl1.

    Phylogenomic databases

    GeneTreei ENSGT00440000033289.
    OMAi PPSCQTG.
    OrthoDBi EOG7353Z9.
    TreeFami TF328601.

    Miscellaneous databases

    NextBioi 35559761.
    SOURCEi Search...

    Gene expression databases

    Bgeei F8WGL3.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR017904. ADF/Cofilin/Destrin.
    IPR027234. Cofilin_1.
    [Graphical view ]
    PANTHERi PTHR11913. PTHR11913. 1 hit.
    PTHR11913:SF17. PTHR11913:SF17. 1 hit.
    Pfami PF00241. Cofilin_ADF. 1 hit.
    [Graphical view ]
    PRINTSi PR00006. COFILIN.
    SMARTi SM00102. ADF. 1 hit.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    6. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF8WGL3_MOUSE
    AccessioniPrimary (citable) accession number: F8WGL3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3