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F8WGL3

- F8WGL3_MOUSE

UniProt

F8WGL3 - F8WGL3_MOUSE

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Protein
Submitted name: Cofilin-1
Gene
Cfl1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. actin filament depolymerization Source: InterPro
  2. actin filament organization Source: MGI
  3. cell projection organization Source: MGI
  4. cellular component movement Source: MGI
  5. establishment of cell polarity Source: MGI
  6. mitotic cytokinesis Source: MGI
  7. negative regulation of cell size Source: MGI
  8. neural crest cell migration Source: MGI
  9. neural fold formation Source: MGI
  10. positive regulation of actin filament depolymerization Source: MGI
  11. protein import into nucleus Source: Ensembl
  12. protein phosphorylation Source: MGI
  13. regulation of cell morphogenesis Source: Ensembl
  14. response to amino acid Source: MGI
  15. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Cofilin-1Imported
Gene namesi
Name:Cfl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:101757. Cfl1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cortical actin cytoskeleton Source: MGI
  3. cytoplasm Source: MGI
  4. lamellipodium Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8WGL3.

Expressioni

Gene expression databases

BgeeiF8WGL3.

Structurei

3D structure databases

ProteinModelPortaliF8WGL3.
SMRiF8WGL3. Positions 1-166.

Family & Domainsi

Sequence similaritiesi

Contains ADF-H domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00440000033289.
OMAiPPSCQTG.
OrthoDBiEOG7353Z9.
TreeFamiTF328601.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
IPR027234. Cofilin_1.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF17. PTHR11913:SF17. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WGL3-1 [UniParc]FASTAAdd to Basket

« Hide

MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE    50
EGKEILVGDV GQTVDDPYTT FVKMLPDKDC RYALYDATYE TKESKKEDLV 100
FIFWAPENAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 150
EKLGGSAVIS LEGKPLSHPA PCLEHLNSPR PALGCCRLPL SCQTGGAGGI 200
PAGGGLSLHP SCQTSLPPPG PSFSLHP 227
Length:227
Mass (Da):24,576
Last modified:September 21, 2011 - v1
Checksum:i2B7C3A4FD13F9830
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126029 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000116560; ENSMUSP00000112259; ENSMUSG00000056201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126029 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8WGL3.
SMRi F8WGL3. Positions 1-166.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F8WGL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000116560 ; ENSMUSP00000112259 ; ENSMUSG00000056201 .

Organism-specific databases

MGIi MGI:101757. Cfl1.

Phylogenomic databases

GeneTreei ENSGT00440000033289.
OMAi PPSCQTG.
OrthoDBi EOG7353Z9.
TreeFami TF328601.

Miscellaneous databases

NextBioi 35559761.
SOURCEi Search...

Gene expression databases

Bgeei F8WGL3.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
IPR027234. Cofilin_1.
[Graphical view ]
PANTHERi PTHR11913. PTHR11913. 1 hit.
PTHR11913:SF17. PTHR11913:SF17. 1 hit.
Pfami PF00241. Cofilin_ADF. 1 hit.
[Graphical view ]
PRINTSi PR00006. COFILIN.
SMARTi SM00102. ADF. 1 hit.
[Graphical view ]
PROSITEi PS51263. ADF_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8WGL3_MOUSE
AccessioniPrimary (citable) accession number: F8WGL3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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