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F8WFW5

- F8WFW5_RAT

UniProt

F8WFW5 - F8WFW5_RAT

Protein
Submitted name:

cGMP-dependent 3',5'-cyclic phosphodiesterase

Gene

Pde2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cAMP binding Source: Ensembl
    2. cGMP binding Source: Ensembl
    3. cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: Ensembl
    4. drug binding Source: Ensembl
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: Ensembl
    2. cAMP-mediated signaling Source: Ensembl
    3. cellular response to cGMP Source: Ensembl
    4. cellular response to drug Source: Ensembl
    5. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
    6. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
    7. cellular response to transforming growth factor beta stimulus Source: Ensembl
    8. cGMP catabolic process Source: Ensembl
    9. cGMP-mediated signaling Source: Ensembl
    10. monocyte differentiation Source: Ensembl
    11. negative regulation of protein import into nucleus, translocation Source: Ensembl
    12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. negative regulation of vascular permeability Source: Ensembl
    14. positive regulation of vascular permeability Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cGMP-dependent 3',5'-cyclic phosphodiesteraseImported
    Gene namesi
    Name:Pde2aImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620965. Pde2a.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: Ensembl
    3. dendrite Source: Ensembl
    4. nucleus Source: Ensembl
    5. perinuclear region of cytoplasm Source: Ensembl
    6. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF8WFW5.

    Structurei

    3D structure databases

    ProteinModelPortaliF8WFW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00750000117253.
    KOiK18283.
    OMAiCFHYTGT.
    OrthoDBiEOG767393.
    TreeFamiTF316499.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 2 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 3 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8WFW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL    50
    SLGAVIDIAG LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP 100
    QEGKIREAVI SRKRLSCDGL GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD 150
    KETGTVAAVI LVHCGQLSDS EEQSLQVVEK HALVALQRVQ ALQQRRPEAV 200
    QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ LKVLRYLQQE 250
    TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC 300
    IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG 350
    DFFTDEDERA IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT 400
    HLDDVSVLLQ EIITEARNLS NAEICSVFLL DQNELVAKVF DGGVVDDESY 450
    EIRIPADQGI AGHVATTGQI LNIPDAYAHP LFYRGVDDST GFRTRNILCF 500
    PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG ISIAHSLLYK 550
    KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY 600
    TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY 650
    HNWMHAFSVS HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN 700
    SFQVASKSVL AALYSSEGSV MERHHFAQAI AILNTHGCNI FDHFSRKDYQ 750
    RMLDLMRDII LATDLAHHLR IFKDLQKMAE VGYDRNNKQH HRLLLCLLMT 800
    SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM EMMDREKAYI 850
    PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR 900
    GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG 935
    Length:935
    Mass (Da):105,234
    Last modified:September 21, 2011 - v1
    Checksum:i3C41479FD7BFC035
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06007567 Genomic DNA. No translation available.
    AABR06007568 Genomic DNA. No translation available.
    RefSeqiNP_001137319.1. NM_001143847.1.
    UniGeneiRn.10044.

    Genome annotation databases

    EnsembliENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
    GeneIDi81743.
    KEGGirno:81743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06007567 Genomic DNA. No translation available.
    AABR06007568 Genomic DNA. No translation available.
    RefSeqi NP_001137319.1. NM_001143847.1.
    UniGenei Rn.10044.

    3D structure databases

    ProteinModelPortali F8WFW5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F8WFW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026586 ; ENSRNOP00000026586 ; ENSRNOG00000019560 .
    GeneIDi 81743.
    KEGGi rno:81743.

    Organism-specific databases

    CTDi 5138.
    RGDi 620965. Pde2a.

    Phylogenomic databases

    GeneTreei ENSGT00750000117253.
    KOi K18283.
    OMAi CFHYTGT.
    OrthoDBi EOG767393.
    TreeFami TF316499.

    Miscellaneous databases

    NextBioi 615464.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 2 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 3 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF8WFW5_RAT
    AccessioniPrimary (citable) accession number: F8WFW5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3