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Protein
Submitted name:

cGMP-dependent 3',5'-cyclic phosphodiesterase

Gene

Pde2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Cofactori

a divalent metal cationSAAS annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.SAAS annotation

GO - Molecular functioni

  1. cAMP binding Source: Ensembl
  2. cGMP binding Source: Ensembl
  3. cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: Ensembl
  4. drug binding Source: Ensembl
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: Ensembl
  2. cAMP-mediated signaling Source: Ensembl
  3. cellular response to cGMP Source: Ensembl
  4. cellular response to drug Source: Ensembl
  5. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  6. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
  7. cellular response to transforming growth factor beta stimulus Source: Ensembl
  8. cGMP catabolic process Source: Ensembl
  9. cGMP-mediated signaling Source: Ensembl
  10. monocyte differentiation Source: Ensembl
  11. negative regulation of protein import into nucleus, translocation Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. negative regulation of vascular permeability Source: Ensembl
  14. positive regulation of vascular permeability Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_246814. G alpha (s) signalling events.
REACT_250690. cGMP effects.

Names & Taxonomyi

Protein namesi
Submitted name:
cGMP-dependent 3',5'-cyclic phosphodiesteraseImported
Gene namesi
Name:Pde2aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620965. Pde2a.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytosol Source: Ensembl
  3. dendrite Source: Ensembl
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8WFW5.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliF8WFW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119066.
KOiK18283.
OMAiRAPINGC.
OrthoDBiEOG767393.
TreeFamiTF316499.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WFW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL
60 70 80 90 100
SLGAVIDIAG LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP
110 120 130 140 150
QEGKIREAVI SRKRLSCDGL GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD
160 170 180 190 200
KETGTVAAVI LVHCGQLSDS EEQSLQVVEK HALVALQRVQ ALQQRRPEAV
210 220 230 240 250
QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ LKVLRYLQQE
260 270 280 290 300
TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC
310 320 330 340 350
IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG
360 370 380 390 400
DFFTDEDERA IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT
410 420 430 440 450
HLDDVSVLLQ EIITEARNLS NAEICSVFLL DQNELVAKVF DGGVVDDESY
460 470 480 490 500
EIRIPADQGI AGHVATTGQI LNIPDAYAHP LFYRGVDDST GFRTRNILCF
510 520 530 540 550
PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG ISIAHSLLYK
560 570 580 590 600
KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY
610 620 630 640 650
TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY
660 670 680 690 700
HNWMHAFSVS HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN
710 720 730 740 750
SFQVASKSVL AALYSSEGSV MERHHFAQAI AILNTHGCNI FDHFSRKDYQ
760 770 780 790 800
RMLDLMRDII LATDLAHHLR IFKDLQKMAE VGYDRNNKQH HRLLLCLLMT
810 820 830 840 850
SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM EMMDREKAYI
860 870 880 890 900
PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR
910 920 930
GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG
Length:935
Mass (Da):105,234
Last modified:September 21, 2011 - v1
Checksum:i3C41479FD7BFC035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06007567 Genomic DNA. No translation available.
AABR06007568 Genomic DNA. No translation available.
RefSeqiNP_001137319.1. NM_001143847.1.
UniGeneiRn.10044.

Genome annotation databases

EnsembliENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
GeneIDi81743.
KEGGirno:81743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06007567 Genomic DNA. No translation available.
AABR06007568 Genomic DNA. No translation available.
RefSeqiNP_001137319.1. NM_001143847.1.
UniGeneiRn.10044.

3D structure databases

ProteinModelPortaliF8WFW5.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiF8WFW5.

Proteomic databases

PRIDEiF8WFW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
GeneIDi81743.
KEGGirno:81743.

Organism-specific databases

CTDi5138.
RGDi620965. Pde2a.

Phylogenomic databases

GeneTreeiENSGT00760000119066.
KOiK18283.
OMAiRAPINGC.
OrthoDBiEOG767393.
TreeFamiTF316499.

Enzyme and pathway databases

ReactomeiREACT_246814. G alpha (s) signalling events.
REACT_250690. cGMP effects.

Miscellaneous databases

NextBioi615464.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF8WFW5_RAT
AccessioniPrimary (citable) accession number: F8WFW5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.