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F8WFW5

- F8WFW5_RAT

UniProt

F8WFW5 - F8WFW5_RAT

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Protein
Submitted name: cGMP-dependent 3',5'-cyclic phosphodiesterase
Gene
Pde2a
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. cAMP binding Source: Ensembl
  2. cGMP binding Source: Ensembl
  3. cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: Ensembl
  4. drug binding Source: Ensembl
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: Ensembl
  2. cAMP-mediated signaling Source: Ensembl
  3. cGMP catabolic process Source: Ensembl
  4. cGMP-mediated signaling Source: Ensembl
  5. cellular response to cGMP Source: Ensembl
  6. cellular response to drug Source: Ensembl
  7. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  8. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
  9. cellular response to transforming growth factor beta stimulus Source: Ensembl
  10. monocyte differentiation Source: Ensembl
  11. negative regulation of protein import into nucleus, translocation Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. negative regulation of vascular permeability Source: Ensembl
  14. positive regulation of vascular permeability Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Keywords - Ligandi

Metal-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
cGMP-dependent 3',5'-cyclic phosphodiesteraseImported
Gene namesi
Name:Pde2aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620965. Pde2a.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytosol Source: Ensembl
  3. dendrite Source: Ensembl
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8WFW5.

Structurei

3D structure databases

ProteinModelPortaliF8WFW5.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00750000117253.
KOiK18283.
OMAiCFHYTGT.
OrthoDBiEOG767393.
TreeFamiTF316499.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WFW5-1 [UniParc]FASTAAdd to Basket

« Hide

MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL    50
SLGAVIDIAG LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP 100
QEGKIREAVI SRKRLSCDGL GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD 150
KETGTVAAVI LVHCGQLSDS EEQSLQVVEK HALVALQRVQ ALQQRRPEAV 200
QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ LKVLRYLQQE 250
TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC 300
IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG 350
DFFTDEDERA IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT 400
HLDDVSVLLQ EIITEARNLS NAEICSVFLL DQNELVAKVF DGGVVDDESY 450
EIRIPADQGI AGHVATTGQI LNIPDAYAHP LFYRGVDDST GFRTRNILCF 500
PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG ISIAHSLLYK 550
KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY 600
TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY 650
HNWMHAFSVS HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN 700
SFQVASKSVL AALYSSEGSV MERHHFAQAI AILNTHGCNI FDHFSRKDYQ 750
RMLDLMRDII LATDLAHHLR IFKDLQKMAE VGYDRNNKQH HRLLLCLLMT 800
SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM EMMDREKAYI 850
PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR 900
GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG 935
Length:935
Mass (Da):105,234
Last modified:September 21, 2011 - v1
Checksum:i3C41479FD7BFC035
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06007567 Genomic DNA. No translation available.
AABR06007568 Genomic DNA. No translation available.
RefSeqiNP_001137319.1. NM_001143847.1.
UniGeneiRn.10044.

Genome annotation databases

EnsembliENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
GeneIDi81743.
KEGGirno:81743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06007567 Genomic DNA. No translation available.
AABR06007568 Genomic DNA. No translation available.
RefSeqi NP_001137319.1. NM_001143847.1.
UniGenei Rn.10044.

3D structure databases

ProteinModelPortali F8WFW5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F8WFW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026586 ; ENSRNOP00000026586 ; ENSRNOG00000019560 .
GeneIDi 81743.
KEGGi rno:81743.

Organism-specific databases

CTDi 5138.
RGDi 620965. Pde2a.

Phylogenomic databases

GeneTreei ENSGT00750000117253.
KOi K18283.
OMAi CFHYTGT.
OrthoDBi EOG767393.
TreeFami TF316499.

Miscellaneous databases

NextBioi 615464.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF8WFW5_RAT
AccessioniPrimary (citable) accession number: F8WFW5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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