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F8WFW5 (F8WFW5_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pde2a Ensembl ENSRNOP00000026586 RGD 620965
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000026586
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length935 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000026586

Ontologies

Keywords
   LigandMetal-binding SAAS SAAS023088
   Molecular functionHydrolase SAAS SAAS023088
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcAMP catabolic process

Inferred from electronic annotation. Source: Ensembl

cAMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cGMP catabolic process

Inferred from electronic annotation. Source: Ensembl

cGMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cellular response to cGMP

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

cellular response to granulocyte macrophage colony-stimulating factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to macrophage colony-stimulating factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

monocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of vascular permeability

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular permeability

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncAMP binding

Inferred from electronic annotation. Source: Ensembl

cGMP binding

Inferred from electronic annotation. Source: Ensembl

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: Ensembl

drug binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F8WFW5 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 3C41479FD7BFC035

FASTA935105,234
        10         20         30         40         50         60 
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL SLGAVIDIAG 

        70         80         90        100        110        120 
LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP QEGKIREAVI SRKRLSCDGL 

       130        140        150        160        170        180 
GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD KETGTVAAVI LVHCGQLSDS EEQSLQVVEK 

       190        200        210        220        230        240 
HALVALQRVQ ALQQRRPEAV QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ 

       250        260        270        280        290        300 
LKVLRYLQQE TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC 

       310        320        330        340        350        360 
IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG DFFTDEDERA 

       370        380        390        400        410        420 
IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT HLDDVSVLLQ EIITEARNLS 

       430        440        450        460        470        480 
NAEICSVFLL DQNELVAKVF DGGVVDDESY EIRIPADQGI AGHVATTGQI LNIPDAYAHP 

       490        500        510        520        530        540 
LFYRGVDDST GFRTRNILCF PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG 

       550        560        570        580        590        600 
ISIAHSLLYK KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY 

       610        620        630        640        650        660 
TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY HNWMHAFSVS 

       670        680        690        700        710        720 
HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN SFQVASKSVL AALYSSEGSV 

       730        740        750        760        770        780 
MERHHFAQAI AILNTHGCNI FDHFSRKDYQ RMLDLMRDII LATDLAHHLR IFKDLQKMAE 

       790        800        810        820        830        840 
VGYDRNNKQH HRLLLCLLMT SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM 

       850        860        870        880        890        900 
EMMDREKAYI PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR 

       910        920        930 
GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000026586.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000026586.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06007567 Genomic DNA. No translation available.
AABR06007568 Genomic DNA. No translation available.
RefSeqNP_001137319.1. NM_001143847.1.
UniGeneRn.10044.

3D structure databases

ProteinModelPortalF8WFW5.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF8WFW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
GeneID81743.
KEGGrno:81743.

Organism-specific databases

CTD5138.
RGD620965. Pde2a.

Phylogenomic databases

GeneTreeENSGT00750000117253.
KOK01120.
OMACFHYTGT.
OrthoDBEOG767393.
TreeFamTF316499.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003018. GAF.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615464.

Entry information

Entry nameF8WFW5_RAT
AccessionPrimary (citable) accession number: F8WFW5
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)