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Protein

Phosphodiesterase

Gene

Pde2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-418457. cGMP effects.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde2aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620965. Pde2a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF8WFW5.
PRIDEiF8WFW5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019560.
ExpressionAtlasiF8WFW5. baseline and differential.
GenevisibleiF8WFW5. RN.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8WFW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 196GAFInterPro annotationAdd BLAST140
Domaini235 – 382GAFInterPro annotationAdd BLAST148
Domaini404 – 553GAFInterPro annotationAdd BLAST150
Domaini648 – 817HDcInterPro annotationAdd BLAST170

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
GeneTreeiENSGT00760000119066.
KOiK18283.
OMAiNREQWTK.
OrthoDBiEOG091G0L2F.
TreeFamiTF316499.

Family and domain databases

CDDicd00077. HDc. 1 hit.
Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiView protein in InterPro
IPR003018. GAF.
IPR029016. GAF-like_dom_sf.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR036971. PDEase_catalytic_dom_sf.
IPR023174. PDEase_CS.
PfamiView protein in Pfam
PF01590. GAF. 1 hit.
PF13185. GAF_2. 1 hit.
PF00233. PDEase_I. 1 hit.
PRINTSiPR00387. PDIESTERASE1.
SMARTiView protein in SMART
SM00065. GAF. 3 hits.
SM00471. HDc. 1 hit.
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiView protein in PROSITE
PS00126. PDEASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

F8WFW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL
60 70 80 90 100
SLGAVIDIAG LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP
110 120 130 140 150
QEGKIREAVI SRKRLSCDGL GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD
160 170 180 190 200
KETGTVAAVI LVHCGQLSDS EEQSLQVVEK HALVALQRVQ ALQQRRPEAV
210 220 230 240 250
QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ LKVLRYLQQE
260 270 280 290 300
TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC
310 320 330 340 350
IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG
360 370 380 390 400
DFFTDEDERA IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT
410 420 430 440 450
HLDDVSVLLQ EIITEARNLS NAEICSVFLL DQNELVAKVF DGGVVDDESY
460 470 480 490 500
EIRIPADQGI AGHVATTGQI LNIPDAYAHP LFYRGVDDST GFRTRNILCF
510 520 530 540 550
PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG ISIAHSLLYK
560 570 580 590 600
KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY
610 620 630 640 650
TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY
660 670 680 690 700
HNWMHAFSVS HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN
710 720 730 740 750
SFQVASKSVL AALYSSEGSV MERHHFAQAI AILNTHGCNI FDHFSRKDYQ
760 770 780 790 800
RMLDLMRDII LATDLAHHLR IFKDLQKMAE VGYDRNNKQH HRLLLCLLMT
810 820 830 840 850
SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM EMMDREKAYI
860 870 880 890 900
PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR
910 920 930
GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG
Length:935
Mass (Da):105,234
Last modified:September 21, 2011 - v1
Checksum:i3C41479FD7BFC035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122631 Genomic DNA. No translation available.
AC128828 Genomic DNA. No translation available.
RefSeqiNP_001137319.1. NM_001143847.1.
UniGeneiRn.10044.

Genome annotation databases

EnsembliENSRNOT00000026586; ENSRNOP00000026586; ENSRNOG00000019560.
GeneIDi81743.
KEGGirno:81743.

Similar proteinsi

Entry informationi

Entry nameiF8WFW5_RAT
AccessioniPrimary (citable) accession number: F8WFW5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported