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Protein

Insulin, isoform 2

Gene

INS-IGF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin, isoform 2
Alternative name(s):
INS-IGF2 readthrough transcript protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33527. INS-IGF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei2121. Hom s Insulin.

Polymorphism and mutation databases

BioMutaiINS-IGF2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Insulin, isoform 2PRO_0000422829Add
BLAST

Proteomic databases

PaxDbiF8WCM5.
PRIDEiF8WCM5.

Expressioni

Tissue specificityi

Expressed in pancreas, eye and, to a lower extent, in limb.1 Publication

Gene expression databases

BgeeiENSG00000129965.
GenevisibleiF8WCM5. HS.

Organism-specific databases

HPAiCAB019430.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348986.

Structurei

3D structure databases

ProteinModelPortaliF8WCM5.
SMRiF8WCM5. Positions 25-54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ9B. Eukaryota.
ENOG41115QQ. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000168644.
InParanoidiF8WCM5.
OMAiTSTWPEG.
OrthoDBiEOG091G0SE5.
PhylomeDBiF8WCM5.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: F8WCM5-1) [UniParc]FASTAAdd to basket
Also known as: INS-IGF2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKTRREAED LQASALSLSS STSTWPEGLD ATARAPPALV VTANIGQAGG
110 120 130 140 150
SSSRQFRQRA LGTSDSPVLF IHCPGAAGTA QGLEYRGRRV TTELVWEEVD
160 170 180 190 200
SSPQPQGSES LPAQPPAQPA PQPEPQQARE PSPEVSCCGL WPRRPQRSQN
Note: Based on a readthrough transcript which may produce an INS-IGF2 fusion protein.
Length:200
Mass (Da):21,537
Last modified:September 21, 2011 - v1
Checksum:iCF5F0050FBF099B2
GO
Isoform 1 (identifier: P01308-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01308.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:110
Mass (Da):11,981
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441L → P in ABD93453 (PubMed:16531418).Curated
Sequence conflicti144 – 1441L → P in ABD93452 (PubMed:16531418).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104204 mRNA. Translation: ABD93452.1.
DQ104205 mRNA. Translation: ABD93453.1.
AC132217 Genomic DNA. No translation available.
CCDSiCCDS41598.1. [F8WCM5-1]
RefSeqiNP_001035835.1. NM_001042376.2. [F8WCM5-1]
UniGeneiHs.272259.
Hs.700350.
Hs.716962.

Genome annotation databases

EnsembliENST00000356578; ENSP00000348986; ENSG00000129965. [F8WCM5-1]
ENST00000397270; ENSP00000380440; ENSG00000129965. [F8WCM5-1]
GeneIDi723961.
KEGGihsa:723961.
UCSCiuc001lvm.4. human. [F8WCM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104204 mRNA. Translation: ABD93452.1.
DQ104205 mRNA. Translation: ABD93453.1.
AC132217 Genomic DNA. No translation available.
CCDSiCCDS41598.1. [F8WCM5-1]
RefSeqiNP_001035835.1. NM_001042376.2. [F8WCM5-1]
UniGeneiHs.272259.
Hs.700350.
Hs.716962.

3D structure databases

ProteinModelPortaliF8WCM5.
SMRiF8WCM5. Positions 25-54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348986.

Protein family/group databases

Allergomei2121. Hom s Insulin.

Polymorphism and mutation databases

BioMutaiINS-IGF2.

Proteomic databases

PaxDbiF8WCM5.
PRIDEiF8WCM5.

Protocols and materials databases

DNASUi723961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356578; ENSP00000348986; ENSG00000129965. [F8WCM5-1]
ENST00000397270; ENSP00000380440; ENSG00000129965. [F8WCM5-1]
GeneIDi723961.
KEGGihsa:723961.
UCSCiuc001lvm.4. human. [F8WCM5-1]

Organism-specific databases

CTDi723961.
GeneCardsiINS-IGF2.
HGNCiHGNC:33527. INS-IGF2.
HPAiCAB019430.
neXtProtiNX_F8WCM5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ9B. Eukaryota.
ENOG41115QQ. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000168644.
InParanoidiF8WCM5.
OMAiTSTWPEG.
OrthoDBiEOG091G0SE5.
PhylomeDBiF8WCM5.

Miscellaneous databases

ChiTaRSiINS-IGF2. human.
GenomeRNAii723961.
PROiF8WCM5.

Gene expression databases

BgeeiENSG00000129965.
GenevisibleiF8WCM5. HS.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINSR2_HUMAN
AccessioniPrimary (citable) accession number: F8WCM5
Secondary accession number(s): Q1WM24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.