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Protein

Serine/threonine-protein kinase

Gene

PRKD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by DAG and phorbol esters.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1
Active sitei714Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi597 – 605ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiF8WBA3.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinaseUniRule annotation (EC:2.7.11.13UniRule annotation)
Gene namesi
Name:PRKD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9407. PRKD1.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184304.

PTM / Processingi

Proteomic databases

MaxQBiF8WBA3.
PaxDbiF8WBA3.
PeptideAtlasiF8WBA3.
PRIDEiF8WBA3.

Expressioni

Gene expression databases

BgeeiENSG00000184304.
ExpressionAtlasiF8WBA3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333568.

Structurei

3D structure databases

ProteinModelPortaliF8WBA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 196Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini278 – 328Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini430 – 549PHInterPro annotationAdd BLAST120
Domaini591 – 847Protein kinaseInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.UniRule annotation
Contains 1 PH domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4236. Eukaryota.
ENOG410XQZ3. LUCA.
GeneTreeiENSGT00840000129794.
OMAiDSGEMQD.
OrthoDBiEOG091G02RG.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015727. Protein_Kinase_C_mu-related.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22968. PTHR22968. 1 hit.
PfamiPF00130. C1_1. 2 hits.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000552. PKC_mu_nu_D2. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8WBA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPPVLRPP SPLLPVAAAA AAAAAALVPG SGPGPAPFLA PVAAPVGGIS
60 70 80 90 100
FHLQIGLSRE PVLLLQDSSG DYSLAHVREM ACSIVDQKFP ECGFYGMYDK
110 120 130 140 150
ILLFRHDPTS ENILQLVKAA SDIQEGDLIE VVLSASATFE DFQIRPHALF
160 170 180 190 200
VHSYRAPAFC DHCGEMLWGL VRQGLKCEGC GLNYHKRCAF KIPNNCSGVR
210 220 230 240 250
RRRLSNVSLT GVSTIRTSSA ELSTSAPDEP LLSPVSPGFE QKSPSESFIG
260 270 280 290 300
REKRSNSQSY IGRPIHLDKI LMSKVKVPHT FVIHSYTRPT VCQYCKKLLK
310 320 330 340 350
GLFRQGLQCK DCRFNCHKRC APKVPNNCLG EVTINGDLLS PGAESDVVME
360 370 380 390 400
EGSDDNDSER NSGLMDDMEE AMVQDAEMAM AECQNDSGEM QDPDPDHEDA
410 420 430 440 450
NRTISPSTSN NIPLMRVVQS VKHTKRKSST VMKEGWMVHY TSKDTLRKRH
460 470 480 490 500
YWRLDSKCIT LFQNDTGSRY YKEIPLSEIL SLEPVKTSAL IPNGANPHCF
510 520 530 540 550
EITTANVVYY VGENVVNPSS PSPNNSVLTS GVGADVARMW EIAIQHALMP
560 570 580 590 600
VIPKGSSVGT GTNLHRDISV SISVSNCQIQ ENVDISTVYQ IFPDEVLGSG
610 620 630 640 650
QFGIVYGGKH RKTGRDVAIK IIDKLRFPTK QESQLRNEVA ILQNLHHPGV
660 670 680 690 700
VNLECMFETP ERVFVVMEKL HGDMLEMILS SEKGRLPEHI TKFLITQILV
710 720 730 740 750
ALRHLHFKNI VHCDLKPENV LLASADPFPQ VKLCDFGFAR IIGEKSFRRS
760 770 780 790 800
VVGTPAYLAP EVLRNKGYNR SLDMWSVGVI IYVSLSGTFP FNEDEDIHDQ
810 820 830 840 850
IQNAAFMYPP NPWKEISHEA IDLINNLLQV KMRKRYSVDK TLSHPWLQDY
860 870 880 890 900
QTWLDLRELE CKIGERYITH ESDDLRWEKY AGEQGLQYPT HLINPSASHS
910 920
DTPETEETEM KALGERVSIL
Length:920
Mass (Da):102,505
Last modified:September 21, 2011 - v1
Checksum:i4F24CAFAD4E77626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121840 Genomic DNA. No translation available.
AL133372 Genomic DNA. No translation available.
AL135858 Genomic DNA. No translation available.
AL355053 Genomic DNA. No translation available.
AL356756 Genomic DNA. No translation available.
AL445884 Genomic DNA. No translation available.
KF455850 Genomic DNA. No translation available.
RefSeqiNP_001316998.1. NM_001330069.1.
UniGeneiHs.508999.

Genome annotation databases

EnsembliENST00000415220; ENSP00000390535; ENSG00000184304.
GeneIDi5587.
UCSCiuc059akr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121840 Genomic DNA. No translation available.
AL133372 Genomic DNA. No translation available.
AL135858 Genomic DNA. No translation available.
AL355053 Genomic DNA. No translation available.
AL356756 Genomic DNA. No translation available.
AL445884 Genomic DNA. No translation available.
KF455850 Genomic DNA. No translation available.
RefSeqiNP_001316998.1. NM_001330069.1.
UniGeneiHs.508999.

3D structure databases

ProteinModelPortaliF8WBA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333568.

Proteomic databases

MaxQBiF8WBA3.
PaxDbiF8WBA3.
PeptideAtlasiF8WBA3.
PRIDEiF8WBA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415220; ENSP00000390535; ENSG00000184304.
GeneIDi5587.
UCSCiuc059akr.1. human.

Organism-specific databases

CTDi5587.
HGNCiHGNC:9407. PRKD1.
OpenTargetsiENSG00000184304.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4236. Eukaryota.
ENOG410XQZ3. LUCA.
GeneTreeiENSGT00840000129794.
OMAiDSGEMQD.
OrthoDBiEOG091G02RG.

Enzyme and pathway databases

SignaLinkiF8WBA3.

Miscellaneous databases

ChiTaRSiPRKD1. human.
GenomeRNAii5587.

Gene expression databases

BgeeiENSG00000184304.
ExpressionAtlasiF8WBA3. baseline and differential.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015727. Protein_Kinase_C_mu-related.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22968. PTHR22968. 1 hit.
PfamiPF00130. C1_1. 2 hits.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000552. PKC_mu_nu_D2. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF8WBA3_HUMAN
AccessioniPrimary (citable) accession number: F8WBA3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.