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Protein

Serine/threonine-protein kinase

Gene

PRKD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by DAG and phorbol esters.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1
Active sitei714Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi597 – 605ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiF8WBA3

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinaseUniRule annotation (EC:2.7.11.13UniRule annotation)
Gene namesi
Name:PRKD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000184304.14
HGNCiHGNC:9407 PRKD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184304

PTM / Processingi

Proteomic databases

EPDiF8WBA3
MaxQBiF8WBA3
PeptideAtlasiF8WBA3
PRIDEiF8WBA3

Expressioni

Gene expression databases

BgeeiENSG00000184304
ExpressionAtlasiF8WBA3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8WBA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 196Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini278 – 328Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini430 – 549PHInterPro annotationAdd BLAST120
Domaini591 – 847Protein kinaseInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4236 Eukaryota
ENOG410XQZ3 LUCA
GeneTreeiENSGT00910000144054
OMAiGEMQDPD
OrthoDBiEOG091G02RG

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015727 Protein_Kinase_C_mu-related
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22968 PTHR22968, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000552 PKC_mu_nu_D2, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

F8WBA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPPVLRPP SPLLPVAAAA AAAAAALVPG SGPGPAPFLA PVAAPVGGIS
60 70 80 90 100
FHLQIGLSRE PVLLLQDSSG DYSLAHVREM ACSIVDQKFP ECGFYGMYDK
110 120 130 140 150
ILLFRHDPTS ENILQLVKAA SDIQEGDLIE VVLSASATFE DFQIRPHALF
160 170 180 190 200
VHSYRAPAFC DHCGEMLWGL VRQGLKCEGC GLNYHKRCAF KIPNNCSGVR
210 220 230 240 250
RRRLSNVSLT GVSTIRTSSA ELSTSAPDEP LLSPVSPGFE QKSPSESFIG
260 270 280 290 300
REKRSNSQSY IGRPIHLDKI LMSKVKVPHT FVIHSYTRPT VCQYCKKLLK
310 320 330 340 350
GLFRQGLQCK DCRFNCHKRC APKVPNNCLG EVTINGDLLS PGAESDVVME
360 370 380 390 400
EGSDDNDSER NSGLMDDMEE AMVQDAEMAM AECQNDSGEM QDPDPDHEDA
410 420 430 440 450
NRTISPSTSN NIPLMRVVQS VKHTKRKSST VMKEGWMVHY TSKDTLRKRH
460 470 480 490 500
YWRLDSKCIT LFQNDTGSRY YKEIPLSEIL SLEPVKTSAL IPNGANPHCF
510 520 530 540 550
EITTANVVYY VGENVVNPSS PSPNNSVLTS GVGADVARMW EIAIQHALMP
560 570 580 590 600
VIPKGSSVGT GTNLHRDISV SISVSNCQIQ ENVDISTVYQ IFPDEVLGSG
610 620 630 640 650
QFGIVYGGKH RKTGRDVAIK IIDKLRFPTK QESQLRNEVA ILQNLHHPGV
660 670 680 690 700
VNLECMFETP ERVFVVMEKL HGDMLEMILS SEKGRLPEHI TKFLITQILV
710 720 730 740 750
ALRHLHFKNI VHCDLKPENV LLASADPFPQ VKLCDFGFAR IIGEKSFRRS
760 770 780 790 800
VVGTPAYLAP EVLRNKGYNR SLDMWSVGVI IYVSLSGTFP FNEDEDIHDQ
810 820 830 840 850
IQNAAFMYPP NPWKEISHEA IDLINNLLQV KMRKRYSVDK TLSHPWLQDY
860 870 880 890 900
QTWLDLRELE CKIGERYITH ESDDLRWEKY AGEQGLQYPT HLINPSASHS
910 920
DTPETEETEM KALGERVSIL
Length:920
Mass (Da):102,505
Last modified:September 21, 2011 - v1
Checksum:i4F24CAFAD4E77626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121840 Genomic DNA No translation available.
AL133372 Genomic DNA No translation available.
AL135858 Genomic DNA No translation available.
AL355053 Genomic DNA No translation available.
AL356756 Genomic DNA No translation available.
AL445884 Genomic DNA No translation available.
KF455850 Genomic DNA No translation available.
RefSeqiNP_001316998.1, NM_001330069.1
UniGeneiHs.508999

Genome annotation databases

EnsembliENST00000415220; ENSP00000390535; ENSG00000184304
GeneIDi5587
UCSCiuc059akr.1 human

Similar proteinsi

Entry informationi

Entry nameiF8WBA3_HUMAN
AccessioniPrimary (citable) accession number: F8WBA3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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