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Protein
Submitted name:

S-adenosylmethionine mitochondrial carrier protein

Gene

SLC25A26

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
S-adenosylmethionine mitochondrial carrier proteinImported
Gene namesi
Name:SLC25A26Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20661. SLC25A26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei48 – 69HelicalSequence analysisAdd BLAST22
Transmembranei234 – 259HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144741.

PTM / Processingi

Proteomic databases

MaxQBiF8WAB8.

Expressioni

Gene expression databases

BgeeiENSG00000144741.
ExpressionAtlasiF8WAB8. baseline and differential.
GenevisibleiF8WAB8. HS.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 77SolcarPROSITE-ProRule annotationAdd BLAST74
Repeati86 – 168SolcarPROSITE-ProRule annotationAdd BLAST83
Repeati177 – 265SolcarPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
GeneTreeiENSGT00550000074950.
KOiK15111.
OMAiLKTRVML.
OrthoDBiEOG091G0G6Z.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

F8WAB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF SKAGGFHGIY
60 70 80 90 100
AGVPSAAIGS FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV
110 120 130 140 150
VACLIRVPSE VVKQRAQVSA STRTFQIFSN ILYEEGIQGL YRGYKSTVLR
160 170 180 190 200
EIPFSLVQFP LWESLKALWS WRQDHVVDSW QSAVCGAFAG GFAAAVTTPL
210 220 230 240 250
DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG VFPRMAAISL
260 270
GGFIFLGAYD RTHSLLLEVG RKSP
Length:274
Mass (Da):29,354
Last modified:September 21, 2011 - v1
Checksum:i97315DE9CC68D19D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092034 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
AC170165 Genomic DNA. No translation available.
AC170801 Genomic DNA. No translation available.
AC235952 Genomic DNA. No translation available.
AEKP01024816 Genomic DNA. No translation available.
AUXG01000021 Genomic DNA. No translation available.
RefSeqiNP_775742.4. NM_173471.3.
UniGeneiHs.379386.

Genome annotation databases

EnsembliENST00000354883; ENSP00000346955; ENSG00000144741.
ENST00000633701; ENSP00000488659; ENSG00000282739.
GeneIDi115286.
KEGGihsa:115286.
UCSCiuc011bfq.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF8WAB8_HUMAN
AccessioniPrimary (citable) accession number: F8WAB8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 5, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported