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Protein

Voltage-dependent R-type calcium channel subunit alpha

Gene

CACNA1E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198216.10
HGNCiHGNC:1392 CACNA1E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 110HelicalSequence analysisAdd BLAST18
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei162 – 180HelicalSequence analysisAdd BLAST19
Transmembranei221 – 243HelicalSequence analysisAdd BLAST23
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Transmembranei328 – 350HelicalSequence analysisAdd BLAST23
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Transmembranei503 – 521HelicalSequence analysisAdd BLAST19
Transmembranei603 – 625HelicalSequence analysisAdd BLAST23
Transmembranei680 – 703HelicalSequence analysisAdd BLAST24
Transmembranei1133 – 1152HelicalSequence analysisAdd BLAST20
Transmembranei1205 – 1224HelicalSequence analysisAdd BLAST20
Transmembranei1270 – 1292HelicalSequence analysisAdd BLAST23
Transmembranei1382 – 1407HelicalSequence analysisAdd BLAST26
Transmembranei1463 – 1481HelicalSequence analysisAdd BLAST19
Transmembranei1493 – 1516HelicalSequence analysisAdd BLAST24
Transmembranei1522 – 1540HelicalSequence analysisAdd BLAST19
Transmembranei1587 – 1605HelicalSequence analysisAdd BLAST19
Transmembranei1680 – 1704HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198216

PTM / Processingi

Proteomic databases

EPDiF8W9Z1
PRIDEiF8W9Z1

Expressioni

Gene expression databases

BgeeiENSG00000198216
ExpressionAtlasiF8W9Z1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8W9Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1720 – 1755EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili699 – 726Sequence analysisAdd BLAST28
Coiled coili1080 – 1102Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF5 Eukaryota
ENOG410YD06 LUCA
GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF57 PTHR10037:SF57, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01633 RVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

F8W9Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM
60 70 80 90 100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII
110 120 130 140 150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF
160 170 180 190 200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL
210 220 230 240 250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA
260 270 280 290 300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
310 320 330 340 350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK
410 420 430 440 450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA
460 470 480 490 500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ
510 520 530 540 550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG
560 570 580 590 600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
610 620 630 640 650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV
660 670 680 690 700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA
710 720 730 740 750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERER
760 770 780 790 800
RRRHHMSVWE QRTSQLRKHM QMSSQEALNR EEAPTMNPLN PLNPLSSLNP
810 820 830 840 850
LNAHPSLYRR PRAIEGLALG LALEKFEEER ISRGGSLKGD GGDRSSALDN
860 870 880 890 900
QRTPLSLGQR EPPWLARPCH GNCDPTQQEA GGGEAVVTFE DRARHRQSQR
910 920 930 940 950
RSRHRRVRTE GKESSSASRS RSASQERSLD EAMPTEGEKD HELRGNHGAK
960 970 980 990 1000
EPTIQEERAQ DLRRTNSLMV SRGSGLAGGL DEADTPLVLP HPELEVGKHV
1010 1020 1030 1040 1050
VLTEQEPEGS SEQALLGNVQ LDMGRVISQS EPDLSCITAN TDKATTESTS
1060 1070 1080 1090 1100
VTVAIPDVDP LVDSTVVHIS NKTDGEASPL KEAEIREDEE EVEKKKQKKE
1110 1120 1130 1140 1150
KRETGKAMVP HSSMFIFSTT NPIRRACHYI VNLRYFEMCI LLVIAASSIA
1160 1170 1180 1190 1200
LAAEDPVLTN SERNKVLRYF DYVFTGVFTF EMVIKMIDQG LILQDGSYFR
1210 1220 1230 1240 1250
DLWNILDFVV VVGALVAFAL ANALGTNKGR DIKTIKSLRV LRVLRPLKTI
1260 1270 1280 1290 1300
KRLPKLKAVF DCVVTSLKNV FNILIVYKLF MFIFAVIAVQ LFKGKFFYCT
1310 1320 1330 1340 1350
DSSKDTEKEC IGNYVDHEKN KMEVKGREWK RHEFHYDNII WALLTLFTVS
1360 1370 1380 1390 1400
TGEGWPQVLQ HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV FPFFFVNIFV
1410 1420 1430 1440 1450
ALIIITFQEQ GDKMMEECSL EKNERACIDF AISAKPLTRY MPQNRHTFQY
1460 1470 1480 1490 1500
RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY YSAPCTYELA LKYLNIAFTM
1510 1520 1530 1540 1550
VFSLECVLKV IAFGFLNYFR DTWNIFDFIT VIGSITEIIL TDSKLVNTSG
1560 1570 1580 1590 1600
FNMSFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF
1610 1620 1630 1640 1650
IYAIIGMQVF GNIKLDEESH INRHNNFRSF FGSLMLLFRS ATGEAWQEIM
1660 1670 1680 1690 1700
LSCLGEKGCE PDTTAPSGQN ENERCGTDLA YVYFVSFIFF CSFLMLNLFV
1710 1720 1730 1740 1750
AVIMDNFEYL TRDSSILGPH HLDEFVRVWA EYDRAACGRI HYTEMYEMLT
1760 1770 1780 1790 1800
LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE DMTVHFTSTL MALIRTALDI
1810 1820 1830 1840 1850
KIAKGGADRQ QLDSELQKET LAIWPHLSQK MLDLLVPMPK ASDLTVGKIY
1860 1870 1880 1890 1900
AAMMIMDYYK QSKVKKQRQQ LEEQKNAPMF QRMEPSSLPQ EIIANAKALP
1910 1920 1930 1940 1950
YLQQDPVSGL SGRSGYPSMS PLSPQDIFQL ACMDPADDGQ FQERQSLEPE
1960 1970 1980 1990 2000
VSELKSVQPS NHGIYLPSDT QEHAGSGRAS SMPRLTVDPQ VVTDPSSMRR
2010 2020 2030 2040 2050
SFSTIRDKRS NSSWLEEFSM ERSSENTYKS RRRSYHSSLR LSAHRLNSDS
2060 2070 2080 2090 2100
GHKSDTHRSG GRERGRSKER KHLLSPDVSR CNSEERGTQA DWESPERRQS
2110 2120 2130 2140 2150
RSPSEGRSQT PNRQGTGSLS ESSIPSVSDT STPRRSRRQL PPVPPKPRPL
2160 2170 2180 2190 2200
LSYSSLIRHA GSISPPADGS EEGSPLTSQA LESNNACLTE SSNSPHPQQS
2210 2220 2230 2240 2250
QHASPQRYIS EPYLALHEDS HASDCGEEET LTFEAAVATS LGRSNTIGSA
2260 2270 2280 2290
PPLRHSWQMP NGHYRRRRRG GPGPGMMCGA VNNLLSDTEE DDKC
Length:2,294
Mass (Da):259,219
Last modified:September 21, 2011 - v1
Checksum:i9821C5DA2F699849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160059 Genomic DNA No translation available.
AL161734 Genomic DNA No translation available.
AL356500 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
KF455083 Genomic DNA No translation available.
KF455110 Genomic DNA No translation available.
KF510705 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000360108; ENSP00000353222; ENSG00000198216
UCSCiuc057nsr.1 human

Similar proteinsi

Entry informationi

Entry nameiF8W9Z1_HUMAN
AccessioniPrimary (citable) accession number: F8W9Z1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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