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Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 6AImported
Gene namesi
Name:KDM6AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147050.14
HGNCiHGNC:12637 KDM6A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147050

PTM / Processingi

Proteomic databases

PeptideAtlasiF8W8R6
PRIDEiF8W8R6

Expressioni

Gene expression databases

BgeeiENSG00000147050
ExpressionAtlasiF8W8R6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8W8R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 361TPR_REGIONInterPro annotationAdd BLAST293
Repeati69 – 102TPRPROSITE-ProRule annotationAdd BLAST34
Repeati106 – 139TPRPROSITE-ProRule annotationAdd BLAST34
Repeati181 – 214TPRPROSITE-ProRule annotationAdd BLAST34
Repeati226 – 259TPRPROSITE-ProRule annotationAdd BLAST34
Repeati260 – 293TPRPROSITE-ProRule annotationAdd BLAST34
Repeati294 – 327TPRPROSITE-ProRule annotationAdd BLAST34
Repeati328 – 361TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1078 – 1241JmjCInterPro annotationAdd BLAST164

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
KOG1246 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00410000025758

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR029516 KDM6C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR14017:SF9 PTHR14017:SF9, 2 hits
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

F8W8R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG
60 70 80 90 100
KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS
110 120 130 140 150
DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG
160 170 180 190 200
LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA
210 220 230 240 250
KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ
260 270 280 290 300
KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI
310 320 330 340 350
GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC
360 370 380 390 400
YLNATRSKSC SNTSALAARI KYLQACKPHH PNTEPVLGLS QTPISQQSLP
410 420 430 440 450
LHMIPSSQVD DLSSPAKRKR TSSPTKNTSD NWSGGHAVSH PPVQQQAHSW
460 470 480 490 500
CLTPQKLQHL EQLRANRNNL NPAQKLMLEQ LESQFVLMQQ HQMRPTGVAQ
510 520 530 540 550
VRSTGIPNGP TADSSLPTNS VSGQQPQLAL TRVPSVSQPG VRPACPGQPL
560 570 580 590 600
ANGPFSAGHV PCSTSRTLGS TDTILIGNNH ITGSGSNGNV PYLQRNALTL
610 620 630 640 650
PHNRTNLTSS AEEPWKNQLS NSTQGLHKGQ SSHSAGPNGE RPLSSTGPSQ
660 670 680 690 700
HLQAAGSGIQ NQNGHPTLPS NSVTQGAALN HLSSHTATSG GQQGITLTKE
710 720 730 740 750
SKPSGNILTV PETSRHTGET PNSTASVEGL PNHVHQMTAD AVCSPSHGDS
760 770 780 790 800
KSPGLLSSDN PQLSALLMGK ANNNVGTGTC DKVNNIHPAV HTKTDNSVAS
810 820 830 840 850
SPSSAISTAT PSPKSTEQTT TNSVTSLNSP HSGLHTINGE GMEESQSPMK
860 870 880 890 900
TDLLLVNHKP SPQIIPSMSV SIYPSSAEVL KACRNLGKNG LSNSSILLDK
910 920 930 940 950
CPPPRPPSSP YPPLPKDKLN PPTPSIYLEN KRDAFFPPLH QFCTNPNNPV
960 970 980 990 1000
TVIRGLAGAL KLDLGLFSTK TLVEANNEHM VEVRTQLLQP ADENWDPTGT
1010 1020 1030 1040 1050
KKIWHCESNR SHTTIAKYAQ YQASSFQESL REENEKRSHH KDHSDSESTS
1060 1070 1080 1090 1100
SDNSGRRRKG PFKTIKFGTN IDLSDDKKWK LQLHELTKLP AFVRVVSAGN
1110 1120 1130 1140 1150
LLSHVGHTIL GMNTVQLYMK VPGSRTPGHQ ENNNFCSVNI NIGPGDCEWF
1160 1170 1180 1190 1200
VVPEGYWGVL NDFCEKNNLN FLMGSWWPNL EDLYEANVPV YRFIQRPGDL
1210 1220 1230 1240 1250
VWINAGTVHW VQAIGWCNNI AWNVGPLTAC QYKLAVERYE WNKLQSVKSI
1260 1270 1280 1290 1300
VPMVHLSWNM ARNIKVSDPK LFEMIKYCLL RTLKQCQTLR EALIAAGKEI
1310 1320 1330 1340 1350
IWHGRTKEEP AHYCSICEVE VFDLLFVTNE SNSRKTYIVH CQDCARKTSG
1360 1370 1380
NLENFVVLEQ YKMEDLMQVY DQFTLAPPLP SASS
Length:1,384
Mass (Da):152,619
Last modified:October 29, 2014 - v2
Checksum:iF51EC414F6398CDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA No translation available.
AL133545 Genomic DNA No translation available.
AL138744 Genomic DNA No translation available.
KF510678 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000382899; ENSP00000372355; ENSG00000147050
UCSCiuc064yru.1 human

Similar proteinsi

Entry informationi

Entry nameiF8W8R6_HUMAN
AccessioniPrimary (citable) accession number: F8W8R6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 29, 2014
Last modified: June 20, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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