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Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 6AImported
Gene namesi
Name:KDM6AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12637. KDM6A.

Expressioni

Gene expression databases

BgeeiF8W8R6.
ExpressionAtlasiF8W8R6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367203.

Structurei

3D structure databases

ProteinModelPortaliF8W8R6.
SMRiF8W8R6. Positions 869-1378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains JmjC domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00410000025758.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8W8R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG
60 70 80 90 100
KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS
110 120 130 140 150
DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG
160 170 180 190 200
LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA
210 220 230 240 250
KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ
260 270 280 290 300
KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI
310 320 330 340 350
GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC
360 370 380 390 400
YLNATRSKSC SNTSALAARI KYLQACKPHH PNTEPVLGLS QTPISQQSLP
410 420 430 440 450
LHMIPSSQVD DLSSPAKRKR TSSPTKNTSD NWSGGHAVSH PPVQQQAHSW
460 470 480 490 500
CLTPQKLQHL EQLRANRNNL NPAQKLMLEQ LESQFVLMQQ HQMRPTGVAQ
510 520 530 540 550
VRSTGIPNGP TADSSLPTNS VSGQQPQLAL TRVPSVSQPG VRPACPGQPL
560 570 580 590 600
ANGPFSAGHV PCSTSRTLGS TDTILIGNNH ITGSGSNGNV PYLQRNALTL
610 620 630 640 650
PHNRTNLTSS AEEPWKNQLS NSTQGLHKGQ SSHSAGPNGE RPLSSTGPSQ
660 670 680 690 700
HLQAAGSGIQ NQNGHPTLPS NSVTQGAALN HLSSHTATSG GQQGITLTKE
710 720 730 740 750
SKPSGNILTV PETSRHTGET PNSTASVEGL PNHVHQMTAD AVCSPSHGDS
760 770 780 790 800
KSPGLLSSDN PQLSALLMGK ANNNVGTGTC DKVNNIHPAV HTKTDNSVAS
810 820 830 840 850
SPSSAISTAT PSPKSTEQTT TNSVTSLNSP HSGLHTINGE GMEESQSPMK
860 870 880 890 900
TDLLLVNHKP SPQIIPSMSV SIYPSSAEVL KACRNLGKNG LSNSSILLDK
910 920 930 940 950
CPPPRPPSSP YPPLPKDKLN PPTPSIYLEN KRDAFFPPLH QFCTNPNNPV
960 970 980 990 1000
TVIRGLAGAL KLDLGLFSTK TLVEANNEHM VEVRTQLLQP ADENWDPTGT
1010 1020 1030 1040 1050
KKIWHCESNR SHTTIAKYAQ YQASSFQESL REENEKRSHH KDHSDSESTS
1060 1070 1080 1090 1100
SDNSGRRRKG PFKTIKFGTN IDLSDDKKWK LQLHELTKLP AFVRVVSAGN
1110 1120 1130 1140 1150
LLSHVGHTIL GMNTVQLYMK VPGSRTPGHQ ENNNFCSVNI NIGPGDCEWF
1160 1170 1180 1190 1200
VVPEGYWGVL NDFCEKNNLN FLMGSWWPNL EDLYEANVPV YRFIQRPGDL
1210 1220 1230 1240 1250
VWINAGTVHW VQAIGWCNNI AWNVGPLTAC QYKLAVERYE WNKLQSVKSI
1260 1270 1280 1290 1300
VPMVHLSWNM ARNIKVSDPK LFEMIKYCLL RTLKQCQTLR EALIAAGKEI
1310 1320 1330 1340 1350
IWHGRTKEEP AHYCSICEVE VFDLLFVTNE SNSRKTYIVH CQDCARKTSG
1360 1370 1380
NLENFVVLEQ YKMEDLMQVY DQFTLAPPLP SASS
Length:1,384
Mass (Da):152,619
Last modified:October 29, 2014 - v2
Checksum:iF51EC414F6398CDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000382899; ENSP00000372355; ENSG00000147050.
UCSCiuc011mlb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF8W8R6.
SMRiF8W8R6. Positions 869-1378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382899; ENSP00000372355; ENSG00000147050.
UCSCiuc011mlb.2. human.

Organism-specific databases

HGNCiHGNC:12637. KDM6A.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00410000025758.

Miscellaneous databases

ChiTaRSiKDM6A. human.
NextBioi35512944.

Gene expression databases

BgeeiF8W8R6.
ExpressionAtlasiF8W8R6. baseline and differential.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:ra46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF8W8R6_HUMAN
AccessioniPrimary (citable) accession number: F8W8R6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: October 29, 2014
Last modified: July 22, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.