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Protein
Submitted name:

Alpha-2-macroglobulin

Gene

A2M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2-macroglobulinImported
Gene namesi
Name:A2MImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175899.14
HGNCiHGNC:7 A2M

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175899

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500337949624 – 168Sequence analysisAdd BLAST145

Proteomic databases

MaxQBiF8W7L3
PeptideAtlasiF8W7L3
PRIDEiF8W7L3

Expressioni

Gene expression databases

BgeeiENSG00000175899
ExpressionAtlasiF8W7L3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8W7L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 163A2M_NInterPro annotationAdd BLAST35

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982

Family and domain databases

InterProiView protein in InterPro
IPR002890 A2M_N
IPR010916 TonB_box_CS
PfamiView protein in Pfam
PF01835 A2M_N, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit

Sequencei

Sequence statusi: Fragment.

F8W7L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL
60 70 80 90 100
LSYLNETVTV SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV
110 120 130 140 150
MFLTVQVKGP TQEFKKRTTV MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS
160
MDENFHPLNE LIPLVYIQ
Length:168
Mass (Da):18,724
Last modified:September 21, 2011 - v1
Checksum:i9D4E7A221AE5F2F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei168Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007436 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000404455; ENSP00000385710; ENSG00000175899
UCSCiuc058kzv.1 human

Similar proteinsi

Entry informationi

Entry nameiF8W7L3_HUMAN
AccessioniPrimary (citable) accession number: F8W7L3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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