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Protein

Histone deacetylase

Gene

hdac6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230Zinc 1Combined sources1
Metal bindingi232Zinc 1; via pros nitrogenCombined sources1
Metal bindingi323Zinc 1Combined sources1
Metal bindingi612Zinc 2Combined sources1
Metal bindingi614Zinc 2; via pros nitrogenCombined sources1
Metal bindingi705Zinc 2Combined sources1
Metal bindingi979Zinc 3Combined sources1
Metal bindingi981Zinc 3; via pros nitrogenCombined sources1
Metal bindingi999Zinc 4Combined sources1
Metal bindingi1002Zinc 4Combined sources1
Metal bindingi1011Zinc 5Combined sources1
Metal bindingi1014Zinc 5Combined sources1
Metal bindingi1019Zinc 4Combined sources1
Metal bindingi1026Zinc 4; via pros nitrogenCombined sources1
Metal bindingi1030Zinc 5; via tele nitrogenCombined sources1
Metal bindingi1036Zinc 5; via pros nitrogenCombined sources1
Metal bindingi1049Zinc 3Combined sources1
Metal bindingi1052Zinc 3Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri997 – 1058UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

  • histone deacetylase activity Source: ZFIN
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • protein deacetylase activity Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • angiogenesis Source: ZFIN
  • definitive hemopoiesis Source: ZFIN
  • hematopoietic progenitor cell differentiation Source: ZFIN
  • protein deacetylation Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation
LigandMetal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

ReactomeiR-DRE-3371511. HSF1 activation.
R-DRE-5617833. Cilium Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:hdac6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-030131-3232. hdac6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF8W4B7.

Expressioni

Gene expression databases

BgeeiENSDARG00000008384.
ExpressionAtlasiF8W4B7. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-62085N.
STRINGi7955.ENSDARP00000124246.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EEFX-ray2.15A/B60-419[»]
5EEIX-ray1.32A/B440-798[»]
5EEKX-ray1.59A440-798[»]
5EEMX-ray2.00A/B440-798[»]
5EENX-ray1.86A/B440-798[»]
5EF7X-ray1.90A/B440-798[»]
5EF8X-ray2.60A/B440-798[»]
5EFBX-ray2.54D440-798[»]
5EFGX-ray2.25A/D440-798[»]
5EFHX-ray2.16A/D440-798[»]
5EFJX-ray1.73D440-798[»]
5EFKX-ray1.82B440-798[»]
5EFNX-ray1.80A/B440-798[»]
5G0FX-ray1.90A974-1081[»]
5G0GX-ray1.50A41-418[»]
5G0HX-ray1.60A40-831[»]
5G0IX-ray1.99A/B25-831[»]
5G0JX-ray2.88A40-831[»]
ProteinModelPortaliF8W4B7.
SMRiF8W4B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini997 – 1058UBP-typeInterPro annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri997 – 1058UBP-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
InParanoidiF8W4B7.
KOiK11407.
OMAiQPHGFCI.
OrthoDBiEOG091G0210.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
PRINTSiPR01270. HDASUPER.
SMARTiView protein in SMART
SM00290. ZnF_UBP. 1 hit.
PROSITEiView protein in PROSITE
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

F8W4B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVPDTKGS SGPPRGTPET KNNKKNLQEA RRKGRMDRSK AEEEMSNELQ
60 70 80 90 100
NLDVQGKSKA TGTGLVYVDA FTRFHCLWDA SHPECPARVS TVMEMLETEG
110 120 130 140 150
LLGRCVQVEA RAVTEDELLL VHTKEYVELM KSTQNMTEEE LKTLAEKYDS
160 170 180 190 200
VYLHPGFFSS ACLSVGSVLQ LVDKVMTSQL RNGFSINRPP GHHAQADKMN
210 220 230 240 250
GFCMFNNLAI AARYAQKRHR VQRVLIVDWD VHHGQGIQYI FEEDPSVLYF
260 270 280 290 300
SVHRYEDGSF WPHLKESDSS SVGSGAGQGY NINLPWNKVG MESGDYITAF
310 320 330 340 350
QQLLLPVAYE FQPQLVLVAA GFDAVIGDPK GGMQVSPECF SILTHMLKGV
360 370 380 390 400
AQGRLVLALE GGYNLQSTAE GVCASMRSLL GDPCPHLPSS GAPCESALKS
410 420 430 440 450
ISKTISDLYP FWKSLQTFEG GPLSEVSPLP APVCAEVKVS SPITGLVYDQ
460 470 480 490 500
RMMLHHNMWD SHHPELPQRI SRIFSRHEEL RLLSRCHRIP ARLATEEELA
510 520 530 540 550
LCHSSKHISI IKSSEHMKPR DLNRLGDEYN SIFISNESYT CALLAAGSCF
560 570 580 590 600
NSAQAILTGQ VRNAVAIVRP PGHHAEKDTA CGFCFFNTAA LTARYAQSIT
610 620 630 640 650
RESLRVLIVD WDVHHGNGTQ HIFEEDDSVL YISLHRYEDG AFFPNSEDAN
660 670 680 690 700
YDKVGLGKGR GYNVNIPWNG GKMGDPEYMA AFHHLVMPIA REFAPELVLV
710 720 730 740 750
SAGFDAARGD PLGGFQVTPE GYAHLTHQLM SLAAGRVLII LEGGYNLTSI
760 770 780 790 800
SESMSMCTSM LLGDSPPSLD HLTPLKTSAT VSINNVLRAH APFWSSLRVN
810 820 830 840 850
IPESLRLSLP SPKPKGKCTP GGKGKKSPRQ STPSQSPGQA THRPDQSGFD
860 870 880 890 900
ELTADLLSLN LNTSTSSNTS PESVAVGGAR RKVKPNTHRV SAGLESESPL
910 920 930 940 950
KLNPEKAGAG DDTDVKAETP NRSISEPVVT CDSSAVKDQE SLVLEAAGGN
960 970 980 990 1000
TVQSVLERVF GAQATDVDTM YVVDPLPWCP HLESVRPVPA GGIDVFQPCE
1010 1020 1030 1040 1050
ECGGEAENWI CLFCYKVLCG RYVNQHMVTH GQESGHPVVL SFADLSVWCY
1060 1070 1080
ACESYVHNKV LHEAKNAAHL VKFGEGIHPF N
Length:1,081
Mass (Da):118,375
Last modified:September 21, 2011 - v1
Checksum:i8807F58CDD0AEFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX469901 Genomic DNA. No translation available.
RefSeqiXP_009302026.1. XM_009303751.2.
XP_009302027.1. XM_009303752.1.
UniGeneiDr.78784.

Genome annotation databases

EnsembliENSDART00000148993; ENSDARP00000124246; ENSDARG00000008384.
GeneIDi565482.
KEGGidre:565482.

Similar proteinsi

Entry informationi

Entry nameiF8W4B7_DANRE
AccessioniPrimary (citable) accession number: F8W4B7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported