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Protein
Submitted name:

TGF-beta receptor type-1

Gene

TGFBR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
TGF-beta receptor type-1Imported
Gene namesi
Name:TGFBR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11772. TGFBR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 82HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106799.

PTM / Processingi

Proteomic databases

MaxQBiF8W0K6.
PaxDbiF8W0K6.
PeptideAtlasiF8W0K6.

Expressioni

Gene expression databases

BgeeiENSG00000106799.
ExpressionAtlasiF8W0K6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 126GSInterPro annotationAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR003605. GS_dom.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
PROSITEiView protein in PROSITE
PS51256. GS. 1 hit.

Sequencei

Sequence statusi: Fragment.

F8W0K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTTGPFSV
60 70 80 90 100
KSSPGLGPVE LAAVIAGPVC FVCISLMLMV YICHNRTVIH HRVPNEEDPS
110 120
LDRPFISEGT TLKDLIYDMT TSGSGS
Length:126
Mass (Da):13,632
Last modified:November 13, 2013 - v2
Checksum:i297C3EA802BB00C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei126Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162427 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000552573; ENSP00000447182; ENSG00000106799.
UCSCiuc064utm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162427 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364133.

Proteomic databases

MaxQBiF8W0K6.
PaxDbiF8W0K6.
PeptideAtlasiF8W0K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552573; ENSP00000447182; ENSG00000106799.
UCSCiuc064utm.1. human.

Organism-specific databases

HGNCiHGNC:11772. TGFBR1.
OpenTargetsiENSG00000106799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.

Miscellaneous databases

ChiTaRSiTGFBR1. human.

Gene expression databases

BgeeiENSG00000106799.
ExpressionAtlasiF8W0K6. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR003605. GS_dom.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
PROSITEiView protein in PROSITE
PS51256. GS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF8W0K6_HUMAN
AccessioniPrimary (citable) accession number: F8W0K6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: November 13, 2013
Last modified: February 15, 2017
This is version 41 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.