ID   F8VWT8_HUMAN            Unreviewed;       155 AA.
AC   F8VWT8;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=BRF1 RNA polymerase III transcription initiation factor subunit {ECO:0000313|Ensembl:ENSP00000449788.1};
DE   Flags: Fragment;
GN   Name=BRF1 {ECO:0000313|Ensembl:ENSP00000449788.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000449788.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000449788.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000449788.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL512355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F8VWT8; -.
DR   SMR; F8VWT8; -.
DR   MassIVE; F8VWT8; -.
DR   MaxQB; F8VWT8; -.
DR   PeptideAtlas; F8VWT8; -.
DR   ProteomicsDB; 29012; -.
DR   Antibodypedia; 14980; 292 antibodies from 29 providers.
DR   Ensembl; ENST00000552127.5; ENSP00000449788.1; ENSG00000185024.18.
DR   UCSC; uc059fzl.1; human.
DR   HGNC; HGNC:11551; BRF1.
DR   VEuPathDB; HostDB:ENSG00000185024; -.
DR   GeneTree; ENSGT00390000010349; -.
DR   OMA; AEPPCKV; -.
DR   ChiTaRS; BRF1; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000185024; Expressed in sural nerve and 129 other cell types or tissues.
DR   ExpressionAtlas; F8VWT8; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd20554; CYCLIN_TFIIIB90_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 1.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   PANTHER; PTHR11618:SF4; TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT; 1.
DR   PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR   Pfam; PF00382; TFIIB; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|EPD:F8VWT8,
KW   ECO:0007829|MaxQB:F8VWT8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          2..65
FT                   /note="Transcription factor TFIIB cyclin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00382"
FT   REGION          135..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          103..130
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         155
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000449788.1"
SQ   SEQUENCE   155 AA;  17502 MW;  0693DAADB2EDFBF3 CRC64;
     MTALRLLQRM KRDWMHTGRR PSGLCGAALL VAARMHDFRR TVKEVISVVK VCESTLRKRL
     TEFEDTPTSQ LTIDEFMKID LEEECDPPSY TAGQRKLRMK QLEQVLSKKL EEVEGEISSY
     QDAIEIELEN SRPKAKGGLA SLAKDGSTED TASSL
//