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Protein

Vasopressin V1a receptor

Gene

AVPR1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptorUniRule annotation
Gene namesi
Name:AVPR1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:895. AVPR1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalUniRule annotationAdd BLAST20
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 132HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166148.

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiF8VW98.
PRIDEiF8VW98.

Expressioni

Gene expression databases

BgeeiENSG00000166148.
ExpressionAtlasiF8VW98. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299178.

Structurei

3D structure databases

ProteinModelPortaliF8VW98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 129G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VW98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGIFVAPV VILGTCYGFI CYNIWCNVRG KTASRQSKGA EQAGVAFQKG
60 70 80 90 100
FLLAPCVSSV KSISRAKIRT VKMTFVIVTA YIVCWAPFFI IQMWSVWDPM
110 120 130 140 150
SVWTESENPT ITITALLGSL NSCCNPWIYM FFSGHLLQDC VQSFPCCQNM
160 170 180
KEKFNKEDTD SMSRRQTFYS NNRSPTNSTD KKMRTG
Length:186
Mass (Da):20,945
Last modified:September 21, 2011 - v1
Checksum:iF6CDF1EB78A3728B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135584 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000550940; ENSP00000449822; ENSG00000166148.
UCSCiuc058qhx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135584 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF8VW98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299178.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiF8VW98.
PRIDEiF8VW98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550940; ENSP00000449822; ENSG00000166148.
UCSCiuc058qhx.1. human.

Organism-specific databases

HGNCiHGNC:895. AVPR1A.
OpenTargetsiENSG00000166148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.

Gene expression databases

BgeeiENSG00000166148.
ExpressionAtlasiF8VW98. baseline and differential.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF8VW98_HUMAN
AccessioniPrimary (citable) accession number: F8VW98
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.