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Protein
Submitted name:

Transmembrane and TPR repeat-containing protein 2

Gene

TMTC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Transmembrane and TPR repeat-containing protein 2Imported
Gene namesi
Name:TMTC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000179104.8
HGNCiHGNC:25440 TMTC2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 106HelicalSequence analysisAdd BLAST22
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei168 – 185HelicalSequence analysisAdd BLAST18
Transmembranei191 – 209HelicalSequence analysisAdd BLAST19
Transmembranei221 – 245HelicalSequence analysisAdd BLAST25
Transmembranei311 – 328HelicalSequence analysisAdd BLAST18
Transmembranei393 – 417HelicalSequence analysisAdd BLAST25
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Transmembranei450 – 468HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500337933322 – 637Sequence analysisAdd BLAST616

Proteomic databases

MaxQBiF8VSH2
PeptideAtlasiF8VSH2
PRIDEiF8VSH2

Expressioni

Gene expression databases

BgeeiENSG00000179104
ExpressionAtlasiF8VSH2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VSH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini493 – 594TPR_REGIONInterPro annotationAdd BLAST102
Repeati493 – 526TPRPROSITE-ProRule annotationAdd BLAST34
Repeati527 – 560TPRPROSITE-ProRule annotationAdd BLAST34
Repeati561 – 594TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

SignalSequence analysis, TPR repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQRH Eukaryota
ENOG410XP5Q LUCA
GeneTreeiENSGT00550000074327

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013618 DUF1736
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF08409 DUF1736, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

F8VSH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND
60 70 80 90 100
FWGTLLTHSG SHKSYRPLCT LSFRLNHAIG GLNPWSYHLV NVLLHAAVTG
110 120 130 140 150
LFTSFSKILL GDGYWTFMAG LMFASHPIHT EAVAGIVGRA DVGASLFFLL
160 170 180 190 200
SLLCYIKHCS TRGYSARTWG WFLGSGLCAG CSMLWKEQGV TVLAVSAVYD
210 220 230 240 250
VFVFHRLKIK QILPTIYKRK NLSLFLSISL LIFWGSSLLG ARLYWMGNKP
260 270 280 290 300
PSFSNSDNPA ADSDSLLTRT LTFFYLPTKN LWLLLCPDTL SFDWSMDAVP
310 320 330 340 350
LLKTVCDWRN LHTVAFYTGL LLLAYYGLKS PSVDRECNGK TVTNGKQNAN
360 370 380 390 400
GHSCLSDVEY QNSETKSSFA SKVENGIKND VSQRTQLPST ENIVVLSLSL
410 420 430 440 450
LIIPFVPATN LFFYVGFVIA ERVLYIPSMG FCLLITVGAR ALYVKVQKRF
460 470 480 490 500
LKSLIFYATA TLIVFYGLKT AIRNGDWQNE EMLYRSGIKV NPAKAWGNLG
510 520 530 540 550
NVLKSQSKIS EAESAYRNAL YYRSNMADML YNLGLLLQEN SRFAEALHYY
560 570 580 590 600
KLAIGSRPTL ASAYLNTGII LMNQGRTEEA RRTFLKCSEI PDENLKDPHA
610 620 630
HKSSVTSCLY NLGKLYHEQG HYEVWPMPLC PFPSPLF
Length:637
Mass (Da):71,424
Last modified:September 21, 2011 - v1
Checksum:iCF2579B37123417C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079595 Genomic DNA No translation available.
AC090667 Genomic DNA No translation available.
AC090680 Genomic DNA No translation available.
AC091214 Genomic DNA No translation available.
AC117375 Genomic DNA No translation available.
RefSeqiNP_001307251.1, NM_001320322.1
UniGeneiHs.577775

Genome annotation databases

EnsembliENST00000548305; ENSP00000448292; ENSG00000179104
GeneIDi160335
UCSCiuc001szr.2 human

Similar proteinsi

Entry informationi

Entry nameiF8VSH2_HUMAN
AccessioniPrimary (citable) accession number: F8VSH2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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