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Protein
Submitted name:

Neuronal PAS domain-containing protein 3

Gene

NPAS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal PAS domain-containing protein 3Imported
Gene namesi
Name:NPAS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19311. NPAS3.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151322.

PTM / Processingi

Proteomic databases

PaxDbiF8VR32.
PRIDEiF8VR32.

Expressioni

Gene expression databases

BgeeiENSG00000151322.
ExpressionAtlasiF8VR32. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8VR32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 111BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST54
Domaini158 – 222PAS (PER-ARNT-SIM)InterPro annotationAdd BLAST65
Domaini339 – 394PAS (PER-ARNT-SIM)InterPro annotationAdd BLAST56

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
OMAiPYSMTKP.
OrthoDBiEOG091G02J4.

Family and domain databases

CDDicd00083. HLH. 1 hit.
cd00130. PAS. 2 hits.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
PfamiView protein in Pfam
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.

Sequencei

Sequence statusi: Complete.

F8VR32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT AEDGASSASS SSQSETPEPV
260 270 280 290 300
ESTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VSLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKT SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGN ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFENPKAGED
560 570 580 590 600
GFGALGAMQI KVERYVESES DLRLQNCESL TSDSAKDSDS AGEAGAQASS
610 620 630 640 650
KHQKRKKRRK RQKGGSASRR RLSSASSPGG LDAGLVEPPR LLSSPNSASV
660 670 680 690 700
LKIKTEISEP INFDNDSSIW NYPPNREISR NESPYSMTKP PSSEHFPSPQ
710 720 730 740 750
GGGGGGGGGG GLHVAIPDSV LTPPGADGAA ARKTQFGASA TAALAPVASD
760 770 780 790 800
PLSPPLSASP RDKHPGNGGG GGGGGGGAGG GGPSASNSLL YTGDLEALQR
810 820 830 840 850
LQAGNVVLPL VHRVTGTLAA TSTAAQRVYT TGTIRYAPAE VTLAMQSNLL
860 870 880 890 900
PNAHAVNFVD VNSPGFGLDP KTPMEMLYHH VHRLNMSGPF GGAVSAASLT
910 920 930
QMPAGNVFTT AEGLFSTLPF PVYSNGIHAA QTLERKED
Length:938
Mass (Da):101,038
Last modified:September 21, 2011 - v1
Checksum:i4FD019CBCCA7C342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109769 Genomic DNA. No translation available.
AL139296 Genomic DNA. No translation available.
AL158802 Genomic DNA. No translation available.
AL355886 Genomic DNA. No translation available.
KC877517 Genomic DNA. No translation available.
KC877522 Genomic DNA. No translation available.
KF455852 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000551492; ENSP00000450392; ENSG00000151322.
UCSCiuc059aqq.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF8VR32_HUMAN
AccessioniPrimary (citable) accession number: F8VR32
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 5, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported