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Protein
Submitted name:

Neuronal PAS domain-containing protein 3

Gene

NPAS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal PAS domain-containing protein 3Imported
Gene namesi
Name:NPAS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19311. NPAS3.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF8VR32.

Expressioni

Gene expression databases

BgeeiENSG00000151322.
ExpressionAtlasiF8VR32. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Structurei

3D structure databases

ProteinModelPortaliF8VR32.
SMRiF8VR32. Positions 59-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 11154BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST
Domaini158 – 22265PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST
Domaini339 – 39456PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
OMAiRKTQFGA.
OrthoDBiEOG091G02J4.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VR32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT AEDGASSASS SSQSETPEPV
260 270 280 290 300
ESTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VSLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKT SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGN ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFENPKAGED
560 570 580 590 600
GFGALGAMQI KVERYVESES DLRLQNCESL TSDSAKDSDS AGEAGAQASS
610 620 630 640 650
KHQKRKKRRK RQKGGSASRR RLSSASSPGG LDAGLVEPPR LLSSPNSASV
660 670 680 690 700
LKIKTEISEP INFDNDSSIW NYPPNREISR NESPYSMTKP PSSEHFPSPQ
710 720 730 740 750
GGGGGGGGGG GLHVAIPDSV LTPPGADGAA ARKTQFGASA TAALAPVASD
760 770 780 790 800
PLSPPLSASP RDKHPGNGGG GGGGGGGAGG GGPSASNSLL YTGDLEALQR
810 820 830 840 850
LQAGNVVLPL VHRVTGTLAA TSTAAQRVYT TGTIRYAPAE VTLAMQSNLL
860 870 880 890 900
PNAHAVNFVD VNSPGFGLDP KTPMEMLYHH VHRLNMSGPF GGAVSAASLT
910 920 930
QMPAGNVFTT AEGLFSTLPF PVYSNGIHAA QTLERKED
Length:938
Mass (Da):101,038
Last modified:September 21, 2011 - v1
Checksum:i4FD019CBCCA7C342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109769 Genomic DNA. No translation available.
AL139296 Genomic DNA. No translation available.
AL158802 Genomic DNA. No translation available.
AL355886 Genomic DNA. No translation available.
KC877517 Genomic DNA. No translation available.
KC877522 Genomic DNA. No translation available.
KF455852 Genomic DNA. No translation available.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

Genome annotation databases

EnsembliENST00000551492; ENSP00000450392; ENSG00000151322.
UCSCiuc059aqq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109769 Genomic DNA. No translation available.
AL139296 Genomic DNA. No translation available.
AL158802 Genomic DNA. No translation available.
AL355886 Genomic DNA. No translation available.
KC877517 Genomic DNA. No translation available.
KC877522 Genomic DNA. No translation available.
KF455852 Genomic DNA. No translation available.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

3D structure databases

ProteinModelPortaliF8VR32.
SMRiF8VR32. Positions 59-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Proteomic databases

PaxDbiF8VR32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000551492; ENSP00000450392; ENSG00000151322.
UCSCiuc059aqq.1. human.

Organism-specific databases

CTDi64067.
HGNCiHGNC:19311. NPAS3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
OMAiRKTQFGA.
OrthoDBiEOG091G02J4.

Miscellaneous databases

ChiTaRSiNPAS3. human.
GenomeRNAii64067.

Gene expression databases

BgeeiENSG00000151322.
ExpressionAtlasiF8VR32. baseline and differential.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF8VR32_HUMAN
AccessioniPrimary (citable) accession number: F8VR32
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.