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Protein

Methionine aminopeptidase 2

Gene

METAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotationSAAS annotation
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.UniRule annotation
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Fe2+SAAS annotation
  • Mn2+SAAS annotation
  • Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230SubstrateUniRule annotation1
Metal bindingi250Divalent metal cation 1UniRule annotation1
Metal bindingi261Divalent metal cation 1UniRule annotation1
Metal bindingi261Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi330Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei338SubstrateUniRule annotation1
Metal bindingi363Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi458Divalent metal cation 1UniRule annotation1
Metal bindingi458Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotationSAAS annotation, Hydrolase, Protease
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Initiation factor 2-associated 67 kDa glycoproteinUniRule annotation
Peptidase MUniRule annotation
Short name:
p67UniRule annotation
Short name:
p67eIF2UniRule annotation
Gene namesi
Name:METAP2UniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111142.13
HGNCiHGNC:16672 METAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111142

PTM / Processingi

Post-translational modificationi

Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.UniRule annotation

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

EPDiF8VQZ7
MaxQBiF8VQZ7
PeptideAtlasiF8VQZ7
PRIDEiF8VQZ7

Expressioni

Gene expression databases

BgeeiENSG00000111142
ExpressionAtlasiF8VQZ7 baseline and differential

Interactioni

Subunit structurei

Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.UniRule annotation

Protein-protein interaction databases

IntActiF8VQZ7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliF8VQZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 464Peptidase_M24InterPro annotationAdd BLAST298

Phylogenomic databases

eggNOGiKOG2775 Eukaryota
COG0024 LUCA
GeneTreeiENSGT00530000063220

Family and domain databases

CDDicd01088 MetAP2, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03175 MetAP_2_euk, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR018349 Pept_M24A_MAP2_BS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit
PROSITEiView protein in PROSITE
PS01202 MAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

F8VQZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA
60 70 80 90 100
GEQEPDKESG ASVDEVARQL ERSALEDKER DEDDEDGDGD GDGATGKKKK
110 120 130 140 150
KKKKKRGPKV QTDPPSVPIC DLYPNGVFPK GQECEYPPTQ DGRTAAWRTT
160 170 180 190 200
SEEKKALDQA SEEIWNDFRE AAEAHRQVRK YVMSWIKPGM TMIEICEKLE
210 220 230 240 250
DCSRKLIKEN GLNAGLAFPT GCSLNNCAAH YTPNAGDTTV LQYDDICKID
260 270 280 290 300
FGTHISGRII DCAFTVTFNP KYDTLLKAVK DATNTGIKCA GIDVRLCDVG
310 320 330 340 350
EAIQEVMESY EVEIDGKTYQ VKPIRNLNGH SIGQYRIHAG KTVPIVKGGE
360 370 380 390 400
ATRMEEGEVY AIETFGSTGK GVVHDDMECS HYMKNFDVGH VPIRLPRTKH
410 420 430 440 450
LLNVINENFG TLAFCRRWLD RLGESKYLMA LKNLCDLGIV DPYPPLCDIK
460 470
GSYTAQFEHT ILLRPTCKEV VSRGDDY
Length:477
Mass (Da):52,820
Last modified:September 21, 2011 - v1
Checksum:i2ABB853D47E76249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018475 Genomic DNA No translation available.
RefSeqiNP_001317175.1, NM_001330246.1
UniGeneiHs.444986

Genome annotation databases

EnsembliENST00000551840; ENSP00000450063; ENSG00000111142
GeneIDi10988
UCSCiuc058ryg.1 human

Similar proteinsi

Entry informationi

Entry nameiF8VQZ7_HUMAN
AccessioniPrimary (citable) accession number: F8VQZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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