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Protein

Tubulin alpha chain

Gene

TUBA1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:TUBA1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000167552.13
HGNCiHGNC:20766 TUBA1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167552

PTM / Processingi

Proteomic databases

EPDiF8VQQ4
MaxQBiF8VQQ4
PeptideAtlasiF8VQQ4
PRIDEiF8VQQ4

Expressioni

Gene expression databases

BgeeiENSG00000167552
ExpressionAtlasiF8VQQ4 baseline and differential

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 211TubulinInterPro annotationAdd BLAST198

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1376 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119060

Family and domain databases

Gene3Di3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Fragment.

F8VQQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDKTIGGG DDSFNTFFSE TGAGKHVPRA VFVDLEPTVI DEVRTGTYRQ
60 70 80 90 100
LFHPEQLITG KEDAANNYAR GHYTIGKEII DLVLDRIRKL ADQCTGLQGF
110 120 130 140 150
LVFHSFGGGT GSGFTSLLME RLSVDYGKKS KLEFSIYPAP QVSTAVVEPY
160 170 180 190 200
NSILTTHTTL EHSDCAFMVD NEAIYDICRR NLDIERPTYT NLNRLIGQIV
210
SSITASLRFD GALNVDLTE
Length:219
Mass (Da):24,221
Last modified:September 21, 2011 - v1
Checksum:i11E75698DC37E45E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei219Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010173 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000547939; ENSP00000450268; ENSG00000167552
UCSCiuc058noj.1 human

Similar proteinsi

Entry informationi

Entry nameiF8VQQ4_HUMAN
AccessioniPrimary (citable) accession number: F8VQQ4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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