Arhgef12

Functionⁱ

GO - Molecular functionⁱ

G-protein coupled receptor binding Source: Ensembl
Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: Ensembl
intracellular signal transduction Source: InterPro
regulation of Rho protein signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation

Molecular function

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Rho guanine nucleotide exchange factor 12Imported
Gene namesⁱ	Name:Arhgef12Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1916882. Arhgef12.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: Ensembl
extracellular exosome Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8VQN6.
PaxDbⁱ	F8VQN6.
PeptideAtlas More...PeptideAtlasⁱ	F8VQN6.
PRIDEⁱ	F8VQN6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000059495.
ExpressionAtlasⁱ	F8VQN6. baseline and differential.
Genevisibleⁱ	F8VQN6. MM.

Interactionⁱ

GO - Molecular functionⁱ

G-protein coupled receptor binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8VQN6.
SMRⁱ	F8VQN6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	72 – 136	PDZ (DHR)InterPro annotationAdd BLAST	65
Domainⁱ	788 – 978	DH (DBL-homology)InterPro annotationAdd BLAST	191
Domainⁱ	1020 – 1133	PHInterPro annotationAdd BLAST	114

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	206 – 259	Sequence analysisAdd BLAST		54

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3520. Eukaryota. COG5422. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119193.
KEGG Orthology (KO) More...KOⁱ	K07532.
OMAⁱ	EWPTERE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CZH.
TreeFamⁱ	TF106495.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR016137. RGS. IPR015212. RGS-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF09128. RGS-like. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF48097. SSF48097. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F8VQN6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSS SHDFDPTDSS 
        60         70         80         90        100
SKKTKSSSEE SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED 
       110        120        130        140        150
GAAMRAGVQT GDRIIKVNGT LVTHSNHLEV VKLIRSGSYV ALTVQGRPPG 
       160        170        180        190        200
SPQIPLADSE VEPSVTGHMS PIMTSPHSPG AAGNMERITS PVLVGEENNV 
       210        220        230        240        250
VHNQKVEILR KMLQKEQERL QLLQEDYNRT ATQRLLKEIQ EAKKHIPQLQ 
       260        270        280        290        300
EQLSKATGSA QDGAVIAPSR PLGDALTLSE AEADPGDGLC RTDWSSGDAS 
       310        320        330        340        350
RPSSDSADSP KSSLRERSYL EEAPERSEGV QDAQEPQSLV GSPSTRGAPH 
       360        370        380        390        400
IIGAEDDDFG TEHEQINGQC SCFQSIELLK SRPAHLAVFL HHVVSQFDPA 
       410        420        430        440        450
TLLCYLYSDL YKQTNSKETR RVFLEFHQFF LDRSAHLKVP VPEEISVDLE 
       460        470        480        490        500
KRRPELIPED LHRLYIQTMQ ERVHPEVQRH LEDFRQKRSM GLTLAESELT 
       510        520        530        540        550
KLDAERDKDR GTLEKERACA EQIVTKIEEV LMTAQAVEEE RSSTMQYVIL 
       560        570        580        590        600
MYMKYLGVKV KEPRNLEHKR GRIGFLPKIK QSMKKDREGE EKGKRRGFPS 
       610        620        630        640        650
ILGPPRRPSR HDNSAIGRAM EIQKSRHPKH LSTPSSVSPE PQDPAKLRQS 
       660        670        680        690        700
GVANEGTDTG YLPASSMSSA TSGTALSQEG GRENDTGTKQ VGEASAPGDC 
       710        720        730        740        750
LDSTPRVPTT VFDFPPPLLD QVQEEECEVE RVAEHGTPKP FRKFDSIAFG 
       760        770        780        790        800
ESQSEDEQFE NDLETDPPNW QQLVSREVLL GLKPSEIKRQ EVINELFYTE 
       810        820        830        840        850
RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL QLHVGLNEQM 
       860        870        880        890        900
KAVRKRNETS VIDHIGEDLL IWFSGPGEEK LKHAAATFCS NQPFALEMIK 
       910        920        930        940        950
SRQKKDSRFH TFVQDAESNP LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK 
       960        970        980        990       1000
YTEWPPEREK VKKAADHCRQ ILNYVNQAVR EAENKQRLED YQRRLDTSNL 
      1010       1020       1030       1040       1050
KLSEYPNVDE LRNLDLTKRK MIHEGPLVWK VNRDKSIDLY TLLLEDILVL 
      1060       1070       1080       1090       1100
LQKQDDRLVL RCHSKILAST ADSKHTFSPV IKLSTVLVRQ VATDNKALFV 
      1110       1120       1130       1140       1150
ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST KPIPLPQPPP 
      1160       1170       1180       1190       1200
CEGDNDEEEP AKLKVEHHDL SVAGLQSPDR VLGLESPLIS SKPQSHSLNT 
      1210       1220       1230       1240       1250
PGKSAAEHLF VTATQFAKEQ HANGALKEGD GGYPVTIPGP HLPVSEERWA 
      1260       1270       1280       1290       1300
LDALRNLGLL KQLLVQQLGL TEKSTQEDWQ SFSRYGPASE EVQADSGIRD 
      1310       1320       1330       1340       1350
LENVKACHAR EGQMSFKTGT GDIATCDSPR TSTESCAAQD SVILASQDSQ 
      1360       1370       1380       1390       1400
ASNVLVMDHM ILTPEMPPAE PEGGLDESGE HFFDAREAHS DDNPSEGDGA 
      1410       1420       1430       1440       1450
VKKEEKDVNL RISGNCLILD GYDAVQESST DEEVASSFPL QPVTGIPAVD 
      1460       1470       1480       1490       1500
SSHQQQHSPQ NVHPEGPVSP FTPEFLVQRH WRAMEDTCFE IQSPSCTDSQ 
      1510       1520       1530       1540 
SQILEYIHKI EADLEHLKKV EESYALLCQR LAGSALPDKL SDKS

Length:1,544

Mass (Da):172,477

Last modified:September 21, 2011 - v1

Checksum:ⁱE0A78631C68D58FA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110169 Genomic DNA. No translation available. AC160123 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_081420.2. NM_027144.2.
UniGeneⁱ	Mm.275266.

Genome annotation databases

Ensemblⁱ	ENSMUST00000165665; ENSMUSP00000126598; ENSMUSG00000059495.
GeneIDⁱ	69632.
KEGGⁱ	mmu:69632.
UCSC genome browser More...UCSCⁱ	uc009pba.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110169 Genomic DNA. No translation available. AC160123 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_081420.2. NM_027144.2.
UniGeneⁱ	Mm.275266.

3D structure databases

ProteinModelPortalⁱ	F8VQN6.
SMRⁱ	F8VQN6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8VQN6.
PaxDbⁱ	F8VQN6.
PeptideAtlas More...PeptideAtlasⁱ	F8VQN6.
PRIDEⁱ	F8VQN6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000165665; ENSMUSP00000126598; ENSMUSG00000059495.
GeneIDⁱ	69632.
KEGGⁱ	mmu:69632.
UCSC genome browser More...UCSCⁱ	uc009pba.1. mouse.

Organism-specific databases

CTDⁱ	23365.
MGIⁱ	MGI:1916882. Arhgef12.

Phylogenomic databases

eggNOGⁱ	KOG3520. Eukaryota. COG5422. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119193.
KEGG Orthology (KO) More...KOⁱ	K07532.
OMAⁱ	EWPTERE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CZH.
TreeFamⁱ	TF106495.

Miscellaneous databases

ChiTaRSⁱ	Arhgef12. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000059495.
ExpressionAtlasⁱ	F8VQN6. baseline and differential.
Genevisibleⁱ	F8VQN6. MM.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR016137. RGS. IPR015212. RGS-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF09128. RGS-like. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF48097. SSF48097. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8VQN6_MOUSE
Accessionⁱ	F8VQN6Primary (citable) accession number: F8VQN6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	July 5, 2017
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8VQN6 (F8VQN6_MOUSE)

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Rho guanine nucleotide exchange factor 12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ