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F8VQM8

- F8VQM8_MOUSE

UniProt

F8VQM8 - F8VQM8_MOUSE

Protein
Submitted name:

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calmodulin binding Source: MGI
    2. damaged DNA binding Source: InterPro
    3. diacylglycerol binding Source: MGI
    4. protein binding Source: MGI
    5. store-operated calcium channel activity Source: MGI

    GO - Biological processi

    1. acrosome reaction Source: MGI
    2. calcium ion transport Source: MGI
    3. female courtship behavior Source: MGI
    4. inter-male aggressive behavior Source: MGI
    5. mating behavior, sex discrimination Source: MGI
    6. negative regulation of male mating behavior Source: MGI
    7. positive regulation of cytosolic calcium ion concentration Source: MGI
    8. regulation of gene expression Source: MGI
    9. response to pheromone Source: MGI
    10. single strand break repair Source: InterPro
    11. territorial aggressive behavior Source: MGI

    Keywords - Molecular functioni

    Ion channelUniRule annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Short transient receptor potential channel 2Imported
    Gene namesi
    Name:Trpc2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109527. Trpc2.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite membrane Source: MGI
    2. endomembrane system Source: MGI
    3. endoplasmic reticulum membrane Source: MGI
    4. Golgi membrane Source: MGI
    5. integral component of membrane Source: UniProtKB-KW
    6. nuclear envelope Source: MGI
    7. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Keywords - Domaini

    ANK repeatSAAS annotation, TransmembraneUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00680000099764.
    OMAiRKDLGNR.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8VQM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPVKISHVV SFSSQDPKYP VENLLNPDSH RGPWLSCPQD KTGQLKVEFQ     50
    LERAVPISYI DVGNCGCAFL QIDVGRSSWP LDRPFVTLLP ATMLMSRTDS 100
    KSGKNRSGVR MFKDGDFLTP ASGESWDRLR LTCSQPFTRH QSFGLAFLRV 150
    RSSLGSLADP VVDPSAPGSS GLNQNSTDVL ESDPRPWLTN PSIRRTFFPD 200
    PQTSTKEISE LKGMLKQLQP GPLGRAARMV LSAARKAPPA SVVSPNNSHG 250
    EPGPSRAESA EPRAEEPNRK TAVGRRKRRK VQEPRRSLSN SSSQPNRRTG 300
    RTRQRQHRPQ TKSDDGGVQA AGQCPICAGF FSIETLPQHA ATCGESPPPQ 350
    PASPASLSSS ESVLRRHHVA LTPVPLVPKP QPNWTEIVNK KLKFPPTLLR 400
    AIQEGQLGLV QQLLESSSDA SGAGPGGPLR NVEESEDRSW REALNLAIRL 450
    GHEVITDVLL ANVKFDFRQI HEALLVAVDT NQPAVVRRLL ARLEREKGRK 500
    VDTKSFSLAF FDSSIDGSRF APGVTPLTLA CQKDLYEIAQ LLMDQGHTIA 550
    RPHPVSCACL ECSNARRYDL LKFSLSRINT YRGIASRAHL SLASEDAMLA 600
    AFQLSRELRR LARKEPEFKP QYIALESLCQ DYGFELLGMC RNQSEVTAVL 650
    NDLGEDSETE PEAEGLGQAF EEGIPNLARL RLAVNYNQKQ FVAHPICQQV 700
    LSSIWCGNLA GWRGSTTIWK LFVAFLIFLT MPFLCIGYWL APKSQLGRLL 750
    KIPVLKFLLH SASYLWFLIF LLGESLVMET QLSTFKGRSQ SVWETSLHMI 800
    WVTGFLWFEC KEVWIEGLRS YLLDWWNFLD VVILSLYLAS FALRLLLAGL 850
    AYMHCRDASD STTCRYFTTA ERSEWRTEDP QFLAEVLFAV TSMLSFTRLA 900
    YILPAHESLG TLQISIGKMI DDMIRFMFIL MIILTAFLCG LNNIYVPYQE 950
    SEKLGNFNET FQFLFWTMFG MEEHTVVDMP QFLVPEFVGR AMYGIFTIVM 1000
    VIVLLNMLIA MITNSFQKIE DDADVEWKFA RSKLYLSYFR EGLTLPVPFN 1050
    ILPSPKAAFY LVRRIFRFLC CGSSCCKAKK SDYPPIGTFT NPGARAGSAG 1100
    EGERVSYRLR VIKALVQRYI ETARREFEET RRKDLGNRLT ELTKTVSRLQ 1150
    SEVASVQKNL AAGGAPRPPD GASILSRYIT RVRNSFQNLG PPTSDTPAEL 1200
    TMPGIVETEV SLGDGLDGTG EAGAPAPGEP GSSSSAHVLV HREQEAEGSG 1250
    DLLLEGDLET KGES 1264
    Length:1,264
    Mass (Da):140,722
    Last modified:September 21, 2011 - v1
    Checksum:i7980E6ED0FD79F73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132297 Genomic DNA. No translation available.
    AC150275 Genomic DNA. No translation available.
    RefSeqiNP_035774.2. NM_011644.3.
    UniGeneiMm.292904.

    Genome annotation databases

    EnsembliENSMUST00000084843; ENSMUSP00000081903; ENSMUSG00000070425.
    ENSMUST00000094129; ENSMUSP00000091679; ENSMUSG00000070425.
    GeneIDi102443351.
    KEGGimmu:102443351.
    UCSCiuc009iql.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132297 Genomic DNA. No translation available.
    AC150275 Genomic DNA. No translation available.
    RefSeqi NP_035774.2. NM_011644.3.
    UniGenei Mm.292904.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 22064.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084843 ; ENSMUSP00000081903 ; ENSMUSG00000070425 .
    ENSMUST00000094129 ; ENSMUSP00000091679 ; ENSMUSG00000070425 .
    GeneIDi 102443351.
    KEGGi mmu:102443351.
    UCSCi uc009iql.1. mouse.

    Organism-specific databases

    CTDi 102443351.
    MGIi MGI:109527. Trpc2.

    Phylogenomic databases

    GeneTreei ENSGT00680000099764.
    OMAi RKDLGNR.
    TreeFami TF313147.

    Miscellaneous databases

    NextBioi 301876.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF8VQM8_MOUSE
    AccessioniPrimary (citable) accession number: F8VQM8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3