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F8VQK3

- F8VQK3_MOUSE

UniProt

F8VQK3 - F8VQK3_MOUSE

Protein
Submitted name:

Protein Gucy1a2

Gene

Gucy1a2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. guanylate cyclase activity Source: Ensembl
    2. heme binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. positive regulation of cGMP biosynthetic process Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Gucy1a2Imported
    Gene namesi
    Name:Gucy1a2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2660877. Gucy1a2.

    PTM / Processingi

    Proteomic databases

    MaxQBiF8VQK3.
    PRIDEiF8VQK3.

    Expressioni

    Gene expression databases

    BgeeiF8VQK3.

    Structurei

    3D structure databases

    ProteinModelPortaliF8VQK3.
    SMRiF8VQK3. Positions 316-431, 444-504, 510-696.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110520.
    KOiK12318.
    OMAiECENTNI.
    OrthoDBiEOG7VX8Z6.
    TreeFamiTF351403.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    PF07700. HNOB. 1 hit.
    PF07701. HNOBA. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111126. SSF111126. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8VQK3-1 [UniParc]FASTAAdd to Basket

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    MSRRKISSES FSSLSSDYLE TSPEEEGECP LSRLCWNGSR SPPGPPGSRE    50
    AAKAATSAPA ASAAAASAAV AAEYKRAQRR GRVNLDSLGE SISLLTAPLP 100
    QTIHMTLKRT LQYYEHQVIG YRDAEKNFHN ISKRCSYADH SNKEEIEDVS 150
    GILQCTANVL GLQFQEIQER FGEEFFKICF DENERVLRAV GSTLQDFFNG 200
    FDALLEHIRT SFGKQATLES SSFLCKELPE GTLMLHYFHP HHTVGFAMLG 250
    MIKAAGKRIY HLNVEVEQIE NEKLCFDGSN PSNCSCLTFL IKECETTQIT 300
    KDNPQGTSQV PADLRISINT FCRAFPFHLM FDSNMVVLQL GEGLRKQLRY 350
    DTHRALKFED CFEIVSPMIN ATFDRVLLRL STPFVIRTKP EASGTENEDK 400
    VMEIKGQMIH VPESSAILFL GSPCVDKLDE LMGRGLHLSD IPIHDATRDV 450
    ILVGEQAKAQ DGLKKRMDKL KATLERTHQA LEEEKKKTVD LLYSIFPGDV 500
    AQQLWQGQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV ISMLNELYTR 550
    FDHQCGLLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE 600
    VLTPDGKAIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH 650
    PRRINVSPTT YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTD 700
    PKPPKPSLSS SRIKKVSYNI GTMFLRETSL 730
    Length:730
    Mass (Da):81,831
    Last modified:September 21, 2011 - v1
    Checksum:iC3907834F882505C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118473 Genomic DNA. No translation available.
    AC122444 Genomic DNA. No translation available.
    AC156642 Genomic DNA. No translation available.
    RefSeqiNP_001028494.1. NM_001033322.2.
    UniGeneiMm.91240.

    Genome annotation databases

    EnsembliENSMUST00000115733; ENSMUSP00000111398; ENSMUSG00000041624.
    GeneIDi234889.
    KEGGimmu:234889.
    UCSCiuc009obc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118473 Genomic DNA. No translation available.
    AC122444 Genomic DNA. No translation available.
    AC156642 Genomic DNA. No translation available.
    RefSeqi NP_001028494.1. NM_001033322.2.
    UniGenei Mm.91240.

    3D structure databases

    ProteinModelPortali F8VQK3.
    SMRi F8VQK3. Positions 316-431, 444-504, 510-696.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi F8VQK3.
    PRIDEi F8VQK3.

    Protocols and materials databases

    DNASUi 234889.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115733 ; ENSMUSP00000111398 ; ENSMUSG00000041624 .
    GeneIDi 234889.
    KEGGi mmu:234889.
    UCSCi uc009obc.2. mouse.

    Organism-specific databases

    CTDi 2977.
    MGIi MGI:2660877. Gucy1a2.

    Phylogenomic databases

    GeneTreei ENSGT00730000110520.
    KOi K12318.
    OMAi ECENTNI.
    OrthoDBi EOG7VX8Z6.
    TreeFami TF351403.

    Miscellaneous databases

    NextBioi 382426.
    PROi F8VQK3.
    SOURCEi Search...

    Gene expression databases

    Bgeei F8VQK3.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    PF07700. HNOB. 1 hit.
    PF07701. HNOBA. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111126. SSF111126. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF8VQK3_MOUSE
    AccessioniPrimary (citable) accession number: F8VQK3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3