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F8VQK3

- F8VQK3_MOUSE

UniProt

F8VQK3 - F8VQK3_MOUSE

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Protein
Submitted name:

Protein Gucy1a2

Gene

Gucy1a2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. guanylate cyclase activity Source: InterPro
  2. heme binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. positive regulation of cGMP biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_245499. Nitric oxide stimulates guanylate cyclase.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Gucy1a2Imported
Gene namesi
Name:Gucy1a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2660877. Gucy1a2.

PTM / Processingi

Proteomic databases

MaxQBiF8VQK3.
PRIDEiF8VQK3.

Expressioni

Gene expression databases

BgeeiF8VQK3.
ExpressionAtlasiF8VQK3. baseline.

Structurei

3D structure databases

ProteinModelPortaliF8VQK3.
SMRiF8VQK3. Positions 316-431, 444-504, 510-696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118959.
InParanoidiF8VQK3.
KOiK12318.
OMAiECENTNI.
OrthoDBiEOG7VX8Z6.
TreeFamiTF351403.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VQK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRKISSES FSSLSSDYLE TSPEEEGECP LSRLCWNGSR SPPGPPGSRE
60 70 80 90 100
AAKAATSAPA ASAAAASAAV AAEYKRAQRR GRVNLDSLGE SISLLTAPLP
110 120 130 140 150
QTIHMTLKRT LQYYEHQVIG YRDAEKNFHN ISKRCSYADH SNKEEIEDVS
160 170 180 190 200
GILQCTANVL GLQFQEIQER FGEEFFKICF DENERVLRAV GSTLQDFFNG
210 220 230 240 250
FDALLEHIRT SFGKQATLES SSFLCKELPE GTLMLHYFHP HHTVGFAMLG
260 270 280 290 300
MIKAAGKRIY HLNVEVEQIE NEKLCFDGSN PSNCSCLTFL IKECETTQIT
310 320 330 340 350
KDNPQGTSQV PADLRISINT FCRAFPFHLM FDSNMVVLQL GEGLRKQLRY
360 370 380 390 400
DTHRALKFED CFEIVSPMIN ATFDRVLLRL STPFVIRTKP EASGTENEDK
410 420 430 440 450
VMEIKGQMIH VPESSAILFL GSPCVDKLDE LMGRGLHLSD IPIHDATRDV
460 470 480 490 500
ILVGEQAKAQ DGLKKRMDKL KATLERTHQA LEEEKKKTVD LLYSIFPGDV
510 520 530 540 550
AQQLWQGQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV ISMLNELYTR
560 570 580 590 600
FDHQCGLLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE
610 620 630 640 650
VLTPDGKAIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH
660 670 680 690 700
PRRINVSPTT YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTD
710 720 730
PKPPKPSLSS SRIKKVSYNI GTMFLRETSL
Length:730
Mass (Da):81,831
Last modified:September 21, 2011 - v1
Checksum:iC3907834F882505C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118473 Genomic DNA. No translation available.
AC122444 Genomic DNA. No translation available.
AC156642 Genomic DNA. No translation available.
RefSeqiNP_001028494.1. NM_001033322.2.
UniGeneiMm.91240.

Genome annotation databases

EnsembliENSMUST00000115733; ENSMUSP00000111398; ENSMUSG00000041624.
GeneIDi234889.
KEGGimmu:234889.
UCSCiuc009obc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118473 Genomic DNA. No translation available.
AC122444 Genomic DNA. No translation available.
AC156642 Genomic DNA. No translation available.
RefSeqi NP_001028494.1. NM_001033322.2.
UniGenei Mm.91240.

3D structure databases

ProteinModelPortali F8VQK3.
SMRi F8VQK3. Positions 316-431, 444-504, 510-696.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi F8VQK3.
PRIDEi F8VQK3.

Protocols and materials databases

DNASUi 234889.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115733 ; ENSMUSP00000111398 ; ENSMUSG00000041624 .
GeneIDi 234889.
KEGGi mmu:234889.
UCSCi uc009obc.2. mouse.

Organism-specific databases

CTDi 2977.
MGIi MGI:2660877. Gucy1a2.

Phylogenomic databases

GeneTreei ENSGT00760000118959.
InParanoidi F8VQK3.
KOi K12318.
OMAi ECENTNI.
OrthoDBi EOG7VX8Z6.
TreeFami TF351403.

Enzyme and pathway databases

Reactomei REACT_245499. Nitric oxide stimulates guanylate cyclase.

Miscellaneous databases

NextBioi 382426.
PROi F8VQK3.
SOURCEi Search...

Gene expression databases

Bgeei F8VQK3.
ExpressionAtlasi F8VQK3. baseline.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VQK3_MOUSE
AccessioniPrimary (citable) accession number: F8VQK3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3