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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 1

Gene

Map3k1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-166058. MyD88:Mal cascade initiated on plasma membrane.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-MMU-975871. MyD88 cascade initiated on plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 1Imported
Gene namesi
Name:Map3k1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1346872. Map3k1.

PTM / Processingi

Proteomic databases

MaxQBiF8VQ72.
PaxDbiF8VQ72.
PeptideAtlasiF8VQ72.
PRIDEiF8VQ72.

Expressioni

Gene expression databases

BgeeiF8VQ72.
ExpressionAtlasiF8VQ72. baseline and differential.
GenevisibleiF8VQ72. MM.

Interactioni

Protein-protein interaction databases

IntActiF8VQ72. 2 interactions.
STRINGi10090.ENSMUSP00000104890.

Structurei

3D structure databases

ProteinModelPortaliF8VQ72.
SMRiF8VQ72. Positions 1214-1486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini333 – 36129SWIM-typeInterPro annotationAdd
BLAST
Domaini438 – 48750RING-typeInterPro annotationAdd
BLAST
Domaini1224 – 1489266Protein kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4279. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
KOiK04416.
OMAiSTHFTRM.
OrthoDBiEOG7MSMNV.
TreeFamiTF105112.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF04434. SWIM. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VQ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGG GGALQGSGAP AAGAAGLLRE
60 70 80 90 100
PGSAGRERAD WRRRQLRKVR SVELDQLPEQ PLFLAAASPP CPSTSPSPEP
110 120 130 140 150
ADAAAGASRF QPAAGPPPPG AASRCGSHSA ELAAARDSGA RSPAGAEPPS
160 170 180 190 200
AAAPSGREME NKETLKGLHK MEDRPEERMI REKLKATCMP AWKHEWLERR
210 220 230 240 250
NRRGPVVVKP IPIKGDGSEM NNLAAEPQGE GQAGSAAPAP KGRRSPSPGS
260 270 280 290 300
SPSGRSVKPE SPGVRRKRVS PVPFQSGRIT PPRRAPSPDG FSPYSPEETS
310 320 330 340 350
RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ NCSCGRGAFC
360 370 380 390 400
IHLLFVMLRV FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR
410 420 430 440 450
NTIQKFVSRM SNCHTLSSSS TSTSSSENSI KDEEEQMCPI CLLGMLDEES
460 470 480 490 500
LTVCEDGCRN KLHHHCMSIW AEECRRNREP LICPLCRSKW RSHDFYSHEL
510 520 530 540 550
SSPVESPTSL RAVQQPSSPQ QPVAGSQRRN QESSFNLTHF GTQQIPSAYK
560 570 580 590 600
DLAEPWIQVF GMELVGCLFS RNWNVREMAL RRLSHDVSGA LLLANGESTG
610 620 630 640 650
NSGGGSGGSL SAGAASGSSQ PSISGDVVEA CCSVLSIVCA DPVYKVYVAA
660 670 680 690 700
LKTLRAMLVY TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS
710 720 730 740 750
TVLELCKGQA GELAVGREIL KAGSIGVGGV DYVLSCILGN QAESNNWQEL
760 770 780 790 800
LGRLCLIDRL LLEFPAEFYP HIVSTDVSQA EPVEIRYKKL LSLLTFALQS
810 820 830 840 850
IDNSHSMVGK LSRRIYLSSA RMVTAVPAVF SKLVTMLNAS GSTHFTRMRR
860 870 880 890 900
RLMAIADEVE IAEVIQLGVE DTVDGHQDSL QVLAPASCLE NSSLEHTVHR
910 920 930 940 950
EKTGKGLSAT RLSASSEDIS DRLAGVSVGL PSSTTTEQPK PAVQTKGRPH
960 970 980 990 1000
SQCLNSSPLS HAQLMFPAPS APCSSAPSVP DISKHRPQAF VPCKIPSASP
1010 1020 1030 1040 1050
QTQRKFSLQF QRNCSEHRDS DQLSPVFTQS RPPPSSNIHR PKPSRPVPGS
1060 1070 1080 1090 1100
TSKLGDATKS SMTLDLGSAS RCDDSFGGGG NSGNAVIPSE ETVFTPVEDK
1110 1120 1130 1140 1150
CRLDVNTELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE KAENDDTYKD
1160 1170 1180 1190 1200
DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
1210 1220 1230 1240 1250
QQDTPETLPG HTKAKQPYRE DAEWLKGQQI GLGAFSSCYQ AQDVGTGTLM
1260 1270 1280 1290 1300
AVKQVTYVRN TSSEQEEVVE ALREEIRMMG HLNHPNIIRM LGATCEKSNY
1310 1320 1330 1340 1350
NLFIEWMAGG SVAHLLSKYG AFKESVVINY TEQLLRGLSY LHENQIIHRD
1360 1370 1380 1390 1400
VKGANLLIDS TGQRLRIADF GAAARLASKG TGAGEFQGQL LGTIAFMAPE
1410 1420 1430 1440 1450
VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT
1460 1470 1480 1490
APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW
Length:1,493
Mass (Da):161,407
Last modified:September 21, 2011 - v1
Checksum:i8E913AE6781B370A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.
RefSeqiNP_036075.2. NM_011945.2.
XP_011242965.1. XM_011244663.1.
UniGeneiMm.15918.

Genome annotation databases

EnsembliENSMUST00000109267; ENSMUSP00000104890; ENSMUSG00000021754.
GeneIDi26401.
KEGGimmu:26401.
UCSCiuc007rwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118704 Genomic DNA. No translation available.
RefSeqiNP_036075.2. NM_011945.2.
XP_011242965.1. XM_011244663.1.
UniGeneiMm.15918.

3D structure databases

ProteinModelPortaliF8VQ72.
SMRiF8VQ72. Positions 1214-1486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF8VQ72. 2 interactions.
STRINGi10090.ENSMUSP00000104890.

Proteomic databases

MaxQBiF8VQ72.
PaxDbiF8VQ72.
PeptideAtlasiF8VQ72.
PRIDEiF8VQ72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109267; ENSMUSP00000104890; ENSMUSG00000021754.
GeneIDi26401.
KEGGimmu:26401.
UCSCiuc007rwa.1. mouse.

Organism-specific databases

CTDi4214.
MGIiMGI:1346872. Map3k1.

Phylogenomic databases

eggNOGiKOG4279. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
KOiK04416.
OMAiSTHFTRM.
OrthoDBiEOG7MSMNV.
TreeFamiTF105112.

Enzyme and pathway databases

ReactomeiR-MMU-166058. MyD88:Mal cascade initiated on plasma membrane.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-MMU-975871. MyD88 cascade initiated on plasma membrane.

Miscellaneous databases

ChiTaRSiMap3k1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiF8VQ72.
ExpressionAtlasiF8VQ72. baseline and differential.
GenevisibleiF8VQ72. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF04434. SWIM. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VQ72_MOUSE
AccessioniPrimary (citable) accession number: F8VQ72
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 6, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.