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Protein
Submitted name:

Laminin subunit alpha-1

Gene

Lama1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-3000157. Laminin interactions.
R-MMU-8874081. MET activates PTK2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit alpha-1Imported
Gene namesi
Name:Lama1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99892. Lama1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500338529325 – 3083Sequence analysisAdd BLAST3059

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi371 ↔ 380PROSITE-ProRule annotation
Disulfide bondi404 ↔ 416PROSITE-ProRule annotation
Disulfide bondi436 ↔ 445PROSITE-ProRule annotation
Disulfide bondi480 ↔ 489PROSITE-ProRule annotation
Disulfide bondi767 ↔ 776PROSITE-ProRule annotation
Disulfide bondi826 ↔ 835PROSITE-ProRule annotation
Disulfide bondi880 ↔ 889PROSITE-ProRule annotation
Disulfide bondi892 ↔ 906PROSITE-ProRule annotation
Disulfide bondi909 ↔ 921PROSITE-ProRule annotation
Disulfide bondi911 ↔ 928PROSITE-ProRule annotation
Disulfide bondi930 ↔ 939PROSITE-ProRule annotation
Disulfide bondi958 ↔ 970PROSITE-ProRule annotation
Disulfide bondi978 ↔ 987PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1032PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1063PROSITE-ProRule annotation
Disulfide bondi1053 ↔ 1070PROSITE-ProRule annotation
Disulfide bondi1072 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1136PROSITE-ProRule annotation
Disulfide bondi1429 ↔ 1438PROSITE-ProRule annotation
Disulfide bondi1486 ↔ 1495PROSITE-ProRule annotation
Disulfide bondi1516 ↔ 1528PROSITE-ProRule annotation
Disulfide bondi1518 ↔ 1535PROSITE-ProRule annotation
Disulfide bondi1537 ↔ 1546PROSITE-ProRule annotation
Disulfide bondi2652 ↔ 2679PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiF8VQ40.
PaxDbiF8VQ40.
PeptideAtlasiF8VQ40.
PRIDEiF8VQ40.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032796.
GenevisibleiF8VQ40. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF8VQ40.
SMRiF8VQ40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 276Laminin N-terminalInterPro annotationAdd BLAST252
Domaini277 – 333Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini334 – 403Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini404 – 460Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini461 – 509Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini530 – 715Laminin IV type AInterPro annotationAdd BLAST186
Domaini749 – 797Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini798 – 855Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini856 – 908Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini909 – 957Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini958 – 1004Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1005 – 1050Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1051 – 1096Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1097 – 1156Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini1184 – 1368Laminin IV type AInterPro annotationAdd BLAST185
Domaini1410 – 1458Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1459 – 1515Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1516 – 1562Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2124 – 2304LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini2312 – 2488LAM_G_DOMAINInterPro annotationAdd BLAST177
Domaini2493 – 2679LAM_G_DOMAINInterPro annotationAdd BLAST187
Domaini2721 – 2893LAM_G_DOMAINInterPro annotationAdd BLAST173
Domaini2898 – 3078LAM_G_DOMAINInterPro annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1619 – 1657Sequence analysisAdd BLAST39
Coiled coili1751 – 1781Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1836. Eukaryota.
ENOG410XRDC. LUCA.
GeneTreeiENSGT00780000121851.
KOiK05637.
OMAiICQPCEC.
OrthoDBiEOG091G005L.
TreeFamiTF335359.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR008979. Galactose-bd-like.
IPR009254. Laminin_aI.
IPR010307. Laminin_domII.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
IPR000034. Laminin_IV.
IPR008211. Laminin_N.
PfamiView protein in Pfam
PF00052. Laminin_B. 2 hits.
PF00053. Laminin_EGF. 17 hits.
PF00054. Laminin_G_1. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
PF00055. Laminin_N. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 10 hits.
SM00180. EGF_Lam. 16 hits.
SM00281. LamB. 2 hits.
SM00282. LamG. 5 hits.
SM00136. LamNT. 1 hit.
SUPFAMiSSF49899. SSF49899. 5 hits.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01248. EGF_LAM_1. 7 hits.
PS50027. EGF_LAM_2. 15 hits.
PS50025. LAM_G_DOMAIN. 5 hits.
PS51115. LAMININ_IVA. 2 hits.
PS51117. LAMININ_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

F8VQ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSGTGAAL LVLLASVLWV TVRSQQRGLF PAILNLATNA HISANATCGE
60 70 80 90 100
KGPEMFCKLV EHVPGRPVRH AQCRVCDGNS TNPRERHPIS HAIDGTNNWW
110 120 130 140 150
QSPSIQNGRE YHWVTVTLDL RQVFQVAYII IKAANAPRPG NWILERSVDG
160 170 180 190 200
VKFKPWQYYA VSDTECLTRY KITPRRGPPT YRADNEVICT SYYSKLVPLE
210 220 230 240 250
HGEIHTSLIN GRPSADDPSP QLLEFTSARY IRLRLQRIRT LNADLMTLSH
260 270 280 290 300
RDLRDLDPIV TRRYYYSIKD ISVGGMCICY GHASSCPWDE EAKQLQCQCE
310 320 330 340 350
HNTCGESCDR CCPGYHQQPW RPGTISSGNE CEECNCHNKA KDCYYDSSVA
360 370 380 390 400
KERRSLNTAG QYSGGGVCVN CSQNTTGINC ETCIDQYYRP HKVSPYDDHP
410 420 430 440 450
CRPCNCDPVG SLSSVCIKDD RHADLANGKW PGQCPCRKGY AGDKCDRCQF
460 470 480 490 500
GYRGFPNCIP CDCRTVGSLN EDPCIEPCLC KKNVEGKNCD RCKPGFYNLK
510 520 530 540 550
ERNPEGCSEC FCFGVSGVCD SLTWSISQVT NMSGWLVTDL MSTNKIRSQQ
560 570 580 590 600
DVLGGHRQIS INNTAVMQRL TSTYYWAAPE AYLGNKLTAF GGFLKYTVSY
610 620 630 640 650
DIPVETVDSD LMSHADIIIK GNGLTISTRA EGLSLQPYEE YFNVVRLVPE
660 670 680 690 700
NFRDFDTRRE IDRDQLMTVL ANVTHLLIRA NYNSAKMALY RLDSVSLDIA
710 720 730 740 750
SPNAIDLAVA ADVEHCECPQ GYTGTSCEAC LPGYYRVDGI LFGGICQPCE
760 770 780 790 800
CHGHASECDI HGICSVCTHN TTGDHCEQCL PGFYGTPSRG TPGDCQPCAC
810 820 830 840 850
PLSIDSNNFS PTCHLTDGEE VVCDQCAPGY SGSWCERCAD GYYGNPTVPG
860 870 880 890 900
GTCVPCNCSG NVDPLEAGHC DSVTGECLKC LWNTDGAHCE RCADGFYGDA
910 920 930 940 950
VTAKNCRACD CHENGSLSGI CHLETGLCDC KPHVTGQQCD QCLSGYYGLD
960 970 980 990 1000
TGLGCVPCNC SVEGSVSDNC TEEGQCHCGP GVSGKQCDRC SHGFYAFQDG
1010 1020 1030 1040 1050
GCTPCDCAHT QNNCDPASGE CLCPPHTQGL KCEECEEAYW GLDPEQGCQA
1060 1070 1080 1090 1100
CNCSAVGSTS AQCDVLSGHC PCKKGFGGQS CHQCSLGYRS FPDCVPCGCD
1110 1120 1130 1140 1150
LRGTLPDTCD LEQGLCSCSE DGGTCSCKEN AVGPQCSKCQ AGTFALRGDN
1160 1170 1180 1190 1200
PQGCSPCFCF GLSQLCSELE GYVRTLITLA SDQPLLHVVS QSNLKGTIEG
1210 1220 1230 1240 1250
VHFQPPDTLL DAEAVRQHIY AEPFYWRLPK QFQGDQLLAY GGKLQYSVAF
1260 1270 1280 1290 1300
YSTLGTGTSN YEPQVLIKGG RARKHVIYMD APAPENGVRQ DYEVRMKEEF
1310 1320 1330 1340 1350
WKYFNSVSEK HVTHSDFMSV LSNIDYILIK ASYGQGLQQS RIANISMEVG
1360 1370 1380 1390 1400
RKAVELPAEG EAALLLELCV CPPGTAGHSC QDCAPGYYRE KLPESGGRGP
1410 1420 1430 1440 1450
RPLLAPCVPC NCNNHSDVCD PETGKCLSCR DHTSGDHCEL CASGYYGKVT
1460 1470 1480 1490 1500
GLPGDCTPCT CPHHPPFSFS PTCVVEGDSD FRCNACLPGY EGQYCERCSA
1510 1520 1530 1540 1550
GYHGNPRAAG GSCQTCDCNP QGSVHSDCDR ASGQCVCKPG ATGLHCEKCL
1560 1570 1580 1590 1600
PRHILMESDC VSCDDDCVGP LLNDLDSVGD AVLSLNLTGV SPAPYGILEN
1610 1620 1630 1640 1650
LENTTKYFQR YLIKENAKKI RAEIQLEGIA EQTENLQKEL TRVLARHQKV
1660 1670 1680 1690 1700
NAEMERTSNG TQALATFIEQ LHANIKEITE KVATLNQTAR KDFQPPVSAL
1710 1720 1730 1740 1750
QSMHQNISSL LGLIKERNFT EMQQNATLEL KAAKDLLSRI QKRFQKPQEK
1760 1770 1780 1790 1800
LKALKEANSL LSNHSEKLQA AEELLKEAGS KTQESNLLLL LVKANLKEFQ
1810 1820 1830 1840 1850
EKKLRVQEEQ NVTSELIAKG REWVDAAGTH TAAAQDTLTQ LEHHRDELLL
1860 1870 1880 1890 1900
WARKIRSHVD DLVMQMSKRR ARDLVHRAEQ HASELQSRAG ALDRDLENVR
1910 1920 1930 1940 1950
NVSLNATSAA HVHSNIQTLT EEAEMLAADA HKTANKTDLI SESLASRGKA
1960 1970 1980 1990 2000
VLQRSSRFLK ESVSTRRKQQ GITMKLDELK NLTSQFQESM DNIMKQANDS
2010 2020 2030 2040 2050
LAMLRESPGG MREKGRKARE LAAAANESAV KTLEDVLALS LRVFNTSEDL
2060 2070 2080 2090 2100
SRVNATVQET NDLLHNSTMT TLLAGRKMKD MEMQANLLLD RLKPLKTLEE
2110 2120 2130 2140 2150
NLSRNLSEIK LLISRARKQV ASIKVAVSAD RDCIRAYQPQ TSSTNYNTLI
2160 2170 2180 2190 2200
LNVKTQEPDN LLFYLGSSSS SDFLAVEMRR GKVAFLWDLG SGSTRLEFPE
2210 2220 2230 2240 2250
VSINNNRWHS IYITRFGNMG SLSVKEASAA ENPPVRTSKS PGPSKVLDIN
2260 2270 2280 2290 2300
NSTLMFVGGL GGQIKKSPAV KVTHFKGCMG EAFLNGKSIG LWNYIEREGK
2310 2320 2330 2340 2350
CNGCFGSSQN EDSSFHFDGS GYAMVEKTLR PTVTQIVILF STFSPNGLLF
2360 2370 2380 2390 2400
YLASNGTKDF LSIELVRGRV KVMVDLGSGP LTLMTDRRYN NGTWYKIAFQ
2410 2420 2430 2440 2450
RNRKQGLLAV FDAYDTSDKE TKQGETPGAA SDLNRLEKDL IYVGGLPHSK
2460 2470 2480 2490 2500
AVRKGVSSRS YVGCIKNLEI SRSTFDLLRN SYGVRKGCAL EPIQSVSFLR
2510 2520 2530 2540 2550
GGYVEMPPKS LSPESSLLAT FATKNSSGIL LVALGKDAEE AGGAQAHVPF
2560 2570 2580 2590 2600
FSIMLLEGRI EVHVNSGDGT SLRKALLHAP TGSYSDGQEH SISLVRNRRV
2610 2620 2630 2640 2650
ITIQVDENSP VEMKLGPLTE GKTIDISNLY IGGLPEDKAT PMLKMRTSFH
2660 2670 2680 2690 2700
GCIKNVVLDA QLLDFTHATG SEQVELDTCL LAEEPMQSLH REHGELPPEP
2710 2720 2730 2740 2750
PTLPQPELCA VDTAPGYVAG AHQFGLSQNS HLVLPLNQSD VRKRLQVQLS
2760 2770 2780 2790 2800
IRTFASSGLI YYVAHQNQMD YATLQLQEGR LHFMFDLGKG RTKVSHPALL
2810 2820 2830 2840 2850
SDGKWHTVKT EYIKRKAFMT VDGQESPSVT VVGNATTLDV ERKLYLGGLP
2860 2870 2880 2890 2900
SHYRARNIGT ITHSIPACIG EIMVNGQQLD KDRPLSASAV DRCYVVAQEG
2910 2920 2930 2940 2950
TFFEGSGYAA LVKEGYKVRL DLNITLEFRT TSKNGVLLGI SSAKVDAIGL
2960 2970 2980 2990 3000
EIVDGKVLFH VNNGAGRITA TYQPRAARAL CDGKWHTLQA HKSKHRIVLT
3010 3020 3030 3040 3050
VDGNSVRAES PHTHSTSADT NDPIYVGGYP AHIKQNCLSS RASFRGCVRN
3060 3070 3080
LRLSRGSQVQ SLDLSRAFDL QGVFPHSCPG PEP
Length:3,083
Mass (Da):338,148
Last modified:September 21, 2011 - v1
Checksum:i4A7C156E40D85DC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154823 Genomic DNA. No translation available.
RefSeqiNP_032506.2. NM_008480.2.
UniGeneiMm.303386.

Genome annotation databases

EnsembliENSMUST00000035471; ENSMUSP00000043957; ENSMUSG00000032796.
GeneIDi16772.
KEGGimmu:16772.
UCSCiuc008dkh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiF8VQ40_MOUSE
AccessioniPrimary (citable) accession number: F8VQ40
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: August 30, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported