Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Laminin subunit alpha-1

Gene

Lama1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-3000157. Laminin interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit alpha-1Imported
Gene namesi
Name:Lama1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99892. Lama1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 30833059Sequence analysisPRO_5003385293Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiF8VQ40.
PaxDbiF8VQ40.

Expressioni

Gene expression databases

BgeeiF8VQ40.
GenevisibleiF8VQ40. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043957.

Structurei

3D structure databases

ProteinModelPortaliF8VQ40.
SMRiF8VQ40. Positions 2708-3082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 276252Laminin N-terminalInterPro annotationAdd
BLAST
Domaini277 – 33357Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini334 – 40370Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini404 – 46057Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini461 – 50949Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini530 – 715186Laminin IV type AInterPro annotationAdd
BLAST
Domaini749 – 79749Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini798 – 85558Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini856 – 90853Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini909 – 95749Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini958 – 100447Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1005 – 105046Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1051 – 109646Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1097 – 115660Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1184 – 1368185Laminin IV type AInterPro annotationAdd
BLAST
Domaini1410 – 145849Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1459 – 151557Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini1516 – 156247Laminin EGF-likeInterPro annotationAdd
BLAST
Domaini2124 – 2304181LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini2312 – 2488177LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini2493 – 2679187LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini2721 – 2893173LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini2898 – 3078181LAM_G_DOMAINInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1619 – 165739Sequence analysisAdd
BLAST
Coiled coili1751 – 178131Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1836. Eukaryota.
ENOG410XRDC. LUCA.
GeneTreeiENSGT00780000121851.
KOiK05637.
OMAiPCDCAHT.
OrthoDBiEOG7SR4KJ.
TreeFamiTF335359.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
InterProiIPR013320. ConA-like_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009254. Laminin_aI.
IPR010307. Laminin_domII.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
IPR000034. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00052. Laminin_B. 2 hits.
PF00053. Laminin_EGF. 17 hits.
PF00054. Laminin_G_1. 5 hits.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00180. EGF_Lam. 16 hits.
SM00281. LamB. 2 hits.
SM00282. LamG. 5 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 5 hits.
PROSITEiPS00022. EGF_1. 11 hits.
PS01248. EGF_LAM_1. 15 hits.
PS50027. EGF_LAM_2. 15 hits.
PS50025. LAM_G_DOMAIN. 5 hits.
PS51115. LAMININ_IVA. 2 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VQ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSGTGAAL LVLLASVLWV TVRSQQRGLF PAILNLATNA HISANATCGE
60 70 80 90 100
KGPEMFCKLV EHVPGRPVRH AQCRVCDGNS TNPRERHPIS HAIDGTNNWW
110 120 130 140 150
QSPSIQNGRE YHWVTVTLDL RQVFQVAYII IKAANAPRPG NWILERSVDG
160 170 180 190 200
VKFKPWQYYA VSDTECLTRY KITPRRGPPT YRADNEVICT SYYSKLVPLE
210 220 230 240 250
HGEIHTSLIN GRPSADDPSP QLLEFTSARY IRLRLQRIRT LNADLMTLSH
260 270 280 290 300
RDLRDLDPIV TRRYYYSIKD ISVGGMCICY GHASSCPWDE EAKQLQCQCE
310 320 330 340 350
HNTCGESCDR CCPGYHQQPW RPGTISSGNE CEECNCHNKA KDCYYDSSVA
360 370 380 390 400
KERRSLNTAG QYSGGGVCVN CSQNTTGINC ETCIDQYYRP HKVSPYDDHP
410 420 430 440 450
CRPCNCDPVG SLSSVCIKDD RHADLANGKW PGQCPCRKGY AGDKCDRCQF
460 470 480 490 500
GYRGFPNCIP CDCRTVGSLN EDPCIEPCLC KKNVEGKNCD RCKPGFYNLK
510 520 530 540 550
ERNPEGCSEC FCFGVSGVCD SLTWSISQVT NMSGWLVTDL MSTNKIRSQQ
560 570 580 590 600
DVLGGHRQIS INNTAVMQRL TSTYYWAAPE AYLGNKLTAF GGFLKYTVSY
610 620 630 640 650
DIPVETVDSD LMSHADIIIK GNGLTISTRA EGLSLQPYEE YFNVVRLVPE
660 670 680 690 700
NFRDFDTRRE IDRDQLMTVL ANVTHLLIRA NYNSAKMALY RLDSVSLDIA
710 720 730 740 750
SPNAIDLAVA ADVEHCECPQ GYTGTSCEAC LPGYYRVDGI LFGGICQPCE
760 770 780 790 800
CHGHASECDI HGICSVCTHN TTGDHCEQCL PGFYGTPSRG TPGDCQPCAC
810 820 830 840 850
PLSIDSNNFS PTCHLTDGEE VVCDQCAPGY SGSWCERCAD GYYGNPTVPG
860 870 880 890 900
GTCVPCNCSG NVDPLEAGHC DSVTGECLKC LWNTDGAHCE RCADGFYGDA
910 920 930 940 950
VTAKNCRACD CHENGSLSGI CHLETGLCDC KPHVTGQQCD QCLSGYYGLD
960 970 980 990 1000
TGLGCVPCNC SVEGSVSDNC TEEGQCHCGP GVSGKQCDRC SHGFYAFQDG
1010 1020 1030 1040 1050
GCTPCDCAHT QNNCDPASGE CLCPPHTQGL KCEECEEAYW GLDPEQGCQA
1060 1070 1080 1090 1100
CNCSAVGSTS AQCDVLSGHC PCKKGFGGQS CHQCSLGYRS FPDCVPCGCD
1110 1120 1130 1140 1150
LRGTLPDTCD LEQGLCSCSE DGGTCSCKEN AVGPQCSKCQ AGTFALRGDN
1160 1170 1180 1190 1200
PQGCSPCFCF GLSQLCSELE GYVRTLITLA SDQPLLHVVS QSNLKGTIEG
1210 1220 1230 1240 1250
VHFQPPDTLL DAEAVRQHIY AEPFYWRLPK QFQGDQLLAY GGKLQYSVAF
1260 1270 1280 1290 1300
YSTLGTGTSN YEPQVLIKGG RARKHVIYMD APAPENGVRQ DYEVRMKEEF
1310 1320 1330 1340 1350
WKYFNSVSEK HVTHSDFMSV LSNIDYILIK ASYGQGLQQS RIANISMEVG
1360 1370 1380 1390 1400
RKAVELPAEG EAALLLELCV CPPGTAGHSC QDCAPGYYRE KLPESGGRGP
1410 1420 1430 1440 1450
RPLLAPCVPC NCNNHSDVCD PETGKCLSCR DHTSGDHCEL CASGYYGKVT
1460 1470 1480 1490 1500
GLPGDCTPCT CPHHPPFSFS PTCVVEGDSD FRCNACLPGY EGQYCERCSA
1510 1520 1530 1540 1550
GYHGNPRAAG GSCQTCDCNP QGSVHSDCDR ASGQCVCKPG ATGLHCEKCL
1560 1570 1580 1590 1600
PRHILMESDC VSCDDDCVGP LLNDLDSVGD AVLSLNLTGV SPAPYGILEN
1610 1620 1630 1640 1650
LENTTKYFQR YLIKENAKKI RAEIQLEGIA EQTENLQKEL TRVLARHQKV
1660 1670 1680 1690 1700
NAEMERTSNG TQALATFIEQ LHANIKEITE KVATLNQTAR KDFQPPVSAL
1710 1720 1730 1740 1750
QSMHQNISSL LGLIKERNFT EMQQNATLEL KAAKDLLSRI QKRFQKPQEK
1760 1770 1780 1790 1800
LKALKEANSL LSNHSEKLQA AEELLKEAGS KTQESNLLLL LVKANLKEFQ
1810 1820 1830 1840 1850
EKKLRVQEEQ NVTSELIAKG REWVDAAGTH TAAAQDTLTQ LEHHRDELLL
1860 1870 1880 1890 1900
WARKIRSHVD DLVMQMSKRR ARDLVHRAEQ HASELQSRAG ALDRDLENVR
1910 1920 1930 1940 1950
NVSLNATSAA HVHSNIQTLT EEAEMLAADA HKTANKTDLI SESLASRGKA
1960 1970 1980 1990 2000
VLQRSSRFLK ESVSTRRKQQ GITMKLDELK NLTSQFQESM DNIMKQANDS
2010 2020 2030 2040 2050
LAMLRESPGG MREKGRKARE LAAAANESAV KTLEDVLALS LRVFNTSEDL
2060 2070 2080 2090 2100
SRVNATVQET NDLLHNSTMT TLLAGRKMKD MEMQANLLLD RLKPLKTLEE
2110 2120 2130 2140 2150
NLSRNLSEIK LLISRARKQV ASIKVAVSAD RDCIRAYQPQ TSSTNYNTLI
2160 2170 2180 2190 2200
LNVKTQEPDN LLFYLGSSSS SDFLAVEMRR GKVAFLWDLG SGSTRLEFPE
2210 2220 2230 2240 2250
VSINNNRWHS IYITRFGNMG SLSVKEASAA ENPPVRTSKS PGPSKVLDIN
2260 2270 2280 2290 2300
NSTLMFVGGL GGQIKKSPAV KVTHFKGCMG EAFLNGKSIG LWNYIEREGK
2310 2320 2330 2340 2350
CNGCFGSSQN EDSSFHFDGS GYAMVEKTLR PTVTQIVILF STFSPNGLLF
2360 2370 2380 2390 2400
YLASNGTKDF LSIELVRGRV KVMVDLGSGP LTLMTDRRYN NGTWYKIAFQ
2410 2420 2430 2440 2450
RNRKQGLLAV FDAYDTSDKE TKQGETPGAA SDLNRLEKDL IYVGGLPHSK
2460 2470 2480 2490 2500
AVRKGVSSRS YVGCIKNLEI SRSTFDLLRN SYGVRKGCAL EPIQSVSFLR
2510 2520 2530 2540 2550
GGYVEMPPKS LSPESSLLAT FATKNSSGIL LVALGKDAEE AGGAQAHVPF
2560 2570 2580 2590 2600
FSIMLLEGRI EVHVNSGDGT SLRKALLHAP TGSYSDGQEH SISLVRNRRV
2610 2620 2630 2640 2650
ITIQVDENSP VEMKLGPLTE GKTIDISNLY IGGLPEDKAT PMLKMRTSFH
2660 2670 2680 2690 2700
GCIKNVVLDA QLLDFTHATG SEQVELDTCL LAEEPMQSLH REHGELPPEP
2710 2720 2730 2740 2750
PTLPQPELCA VDTAPGYVAG AHQFGLSQNS HLVLPLNQSD VRKRLQVQLS
2760 2770 2780 2790 2800
IRTFASSGLI YYVAHQNQMD YATLQLQEGR LHFMFDLGKG RTKVSHPALL
2810 2820 2830 2840 2850
SDGKWHTVKT EYIKRKAFMT VDGQESPSVT VVGNATTLDV ERKLYLGGLP
2860 2870 2880 2890 2900
SHYRARNIGT ITHSIPACIG EIMVNGQQLD KDRPLSASAV DRCYVVAQEG
2910 2920 2930 2940 2950
TFFEGSGYAA LVKEGYKVRL DLNITLEFRT TSKNGVLLGI SSAKVDAIGL
2960 2970 2980 2990 3000
EIVDGKVLFH VNNGAGRITA TYQPRAARAL CDGKWHTLQA HKSKHRIVLT
3010 3020 3030 3040 3050
VDGNSVRAES PHTHSTSADT NDPIYVGGYP AHIKQNCLSS RASFRGCVRN
3060 3070 3080
LRLSRGSQVQ SLDLSRAFDL QGVFPHSCPG PEP
Length:3,083
Mass (Da):338,148
Last modified:September 21, 2011 - v1
Checksum:i4A7C156E40D85DC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154823 Genomic DNA. No translation available.
RefSeqiNP_032506.2. NM_008480.2.
UniGeneiMm.303386.

Genome annotation databases

EnsembliENSMUST00000035471; ENSMUSP00000043957; ENSMUSG00000032796.
GeneIDi16772.
KEGGimmu:16772.
UCSCiuc008dkh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154823 Genomic DNA. No translation available.
RefSeqiNP_032506.2. NM_008480.2.
UniGeneiMm.303386.

3D structure databases

ProteinModelPortaliF8VQ40.
SMRiF8VQ40. Positions 2708-3082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043957.

Proteomic databases

MaxQBiF8VQ40.
PaxDbiF8VQ40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035471; ENSMUSP00000043957; ENSMUSG00000032796.
GeneIDi16772.
KEGGimmu:16772.
UCSCiuc008dkh.1. mouse.

Organism-specific databases

CTDi284217.
MGIiMGI:99892. Lama1.

Phylogenomic databases

eggNOGiKOG1836. Eukaryota.
ENOG410XRDC. LUCA.
GeneTreeiENSGT00780000121851.
KOiK05637.
OMAiPCDCAHT.
OrthoDBiEOG7SR4KJ.
TreeFamiTF335359.

Enzyme and pathway databases

ReactomeiR-MMU-3000157. Laminin interactions.

Miscellaneous databases

NextBioi290602.
SOURCEiSearch...

Gene expression databases

BgeeiF8VQ40.
GenevisibleiF8VQ40. MM.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
InterProiIPR013320. ConA-like_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009254. Laminin_aI.
IPR010307. Laminin_domII.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
IPR000034. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00052. Laminin_B. 2 hits.
PF00053. Laminin_EGF. 17 hits.
PF00054. Laminin_G_1. 5 hits.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00180. EGF_Lam. 16 hits.
SM00281. LamB. 2 hits.
SM00282. LamG. 5 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 5 hits.
PROSITEiPS00022. EGF_1. 11 hits.
PS01248. EGF_LAM_1. 15 hits.
PS50027. EGF_LAM_2. 15 hits.
PS50025. LAM_G_DOMAIN. 5 hits.
PS51115. LAMININ_IVA. 2 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VQ40_MOUSE
AccessioniPrimary (citable) accession number: F8VQ40
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 11, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.