IQ motif-containing GTPase-activating protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calmodulin binding Source: MGI
• myosin VI light chain binding Source: MGI
• Ras GTPase binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18604197
• Rho GTPase binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18604197

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• activation of MAPK activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• cellular response to organic substance Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18604197
• ERK1 and ERK2 cascade Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• G1/S transition of mitotic cell cycle Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• negative regulation of gene expression Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• positive regulation of gene expression Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• positive regulation of mammary gland epithelial cell proliferation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• positive regulation of protein phosphorylation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• Ras protein signal transduction Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• regulation of cell size Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18604197
• regulation of GTPase activity Source: InterPro

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cell-cell junction Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18604197
• cytoplasm Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18604197
• lateral plasma membrane Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18604197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calmodulin binding Source: MGI
• myosin VI light chain binding Source: MGI
• Ras GTPase binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18604197
• Rho GTPase binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18604197

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEPCAAGRAR TAYERLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEVCLKE 
        60         70         80         90        100
ELPSPVELEE SLRNGVLLAK LGHCFAPSVV PLKKIYDVEQ LRYQATGLHF 
       110        120        130        140        150
RHTDNINFWL SAVAHIGLPS IFLPETTDIY DKKNMPRVIY CIHALSLFLF 
       160        170        180        190        200
RLGLAPQIHD LYGKVKFTAE ELGNIASELA KYGLQLPAFS KIGGILANEF 
       210        220        230        240        250
SADEAAVHAA ILAINDAVER GVVEDTLVTL QNPNALLGNL REPLAAVYQE 
       260        270        280        290        300
LLALAKMEKA ANARNHDDGQ EQDIYESCLT QAEIQGHINL ANVQGALEVV 
       310        320        330        340        350
DDALERQNPG ALLEALHDPV LALQGVRGTF ADWYLEQLTS DREQKSQELG 
       360        370        380        390        400
LVRLLEKEEI QAGVAVANEK GDEEQTMLQA VWRINKAIRR GVAADTVKEL 
       410        420        430        440        450
MCPEAQLPRV YPFASAFYQQ ELALLQKQQQ GELGQEELFV AVEMLSAVVL 
       460        470        480        490        500
INRALEAGDV CAFWDNLVNP ATGLAQVEEE NAQRYFDALV KVQQFQGTHR 
       510        520        530        540        550
GILSWNDLQA AVSQVNEQVQ EETDQVLAIS LINEALDQGC PEKTLSALLL 
       560        570        580        590        600
PAAGLEDVSL HVAPRYHLLL VAAKRQKARV TGDPGAVLWL EEIRQGVARA 
       610        620        630        640        650
NEDTSTAQRI ALGVAAINQA IKEGKAAQTE RVLRNPNVAL RGIVPDCAKS 
       660        670        680        690        700
YQQALEGAAA KKQCPGDTAF WVQHDMKDGT AYYLHLQTFQ GTWEHPSGCH 
       710        720        730        740        750
LNTSHLTWEE IQSVITKVTA AHDRQLLWKA NVGFVIKLQA RLRGFLVRQK 
       760        770        780        790        800
FAESSHVFRT LLPAVIKIQA HWRGYRQRKA YQERLQHFKA NLDAIIKIQA 
       810        820        830        840        850
WARMWAARRR YLRRLRYFQK NVDSVVKIQA FFRARKARDD YRMLVHARHP 
       860        870        880        890        900
PLCVVRKFAH LLNQSQEDFS AESELLKLQE EVVRKIRSNQ QLEQDLNLMD 
       910        920        930        940        950
IKIGLLVKNR ITLQEVVSHC KKLTKKNKEQ LSDMMILDKQ KGLKSLSREK 
       960        970        980        990       1000
RQKLEAYQHL FYLLQTQPIY LAKLIFQMPQ NKTTKFMEGV IFSLYNYASN 
      1010       1020       1030       1040       1050
RREAYLLLQL FRTALQEEIK SKVEQPQDVV TGNPTVVRLV VRFYRNGRGQ 
      1060       1070       1080       1090       1100
SALQEILGKV IQDVLEDRSV SIHTDPVHIY KSWINQEEAQ TGQRSHLPYD 
      1110       1120       1130       1140       1150
VTPEQALSHS EVQRRLDISL RSLLTLTEKF FVAISSSVDH IPYGMRYMAK 
      1160       1170       1180       1190       1200
VLKTTLEKKF PNATERDIYK VVGNLLYYRF LNPAVVAPDA FDIVAMAAGS 
      1210       1220       1230       1240       1250
TLAAPQRHAL GAVAQLLQHA AAGQIFSGES RHLRVLNDYL EDLHLKFRKF 
      1260       1270       1280       1290       1300
ICRACRVPEP EERFAIDEYS DMVAVAKPMV YITVGELIGT HRLLLEHQDQ 
      1310       1320       1330       1340       1350
LAPGHQDPLH QLLEDLGEPP TISDLIGDNI ATDGHVDLSR LEVSLTLTNK 
      1360       1370       1380       1390       1400
FEGLETDADH NSNQSLLLST KQMLADLIQF HPGESLEEIL TSSAPREHEE 
      1410       1420       1430       1440       1450
AHRRLMCWRQ ACDTQKPEPL RRHHSLMAHS LLSLSEKQQR VLRNLRRLQG 
      1460       1470       1480       1490       1500
LGLVRASDCY QGLVDELAKD ICNQRRHRQR RKAEMLRLRT TLQGLDAKTI 
      1510       1520       1530       1540       1550
FYEEQGDYYN QYIQACLDHL APKPKSSGKG KKQPSLHYTA AQLLEKGVLV 
      1560       1570       1580       1590       1600
EIEDLPVSHF RNVIFDITPG DEAGRFFVNA KFLGVDMEKF QLHYQDLLQL 
      1610       1620       1630 
QYEGVAVMKL FNKAKVNVNL LIFLLNKKFL RK            

Sequence databases

Genome annotation databases

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Caution

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ