Pxn

Functionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
integrin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
protein kinase binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl
vinculin binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cell-matrix adhesion Source: InterPro
cellular response to reactive oxygen species Source: Ensembl
growth hormone receptor signaling pathway Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: PaxillinImported
Gene namesⁱ	Name:PxnImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:108295. Pxn.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Ensembl
focal adhesion Source: Ensembl
lamellipodium Source: Ensembl
plasma membrane Source: Ensembl
stress fiber Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8VQ28.
PaxDbⁱ	F8VQ28.
PeptideAtlas More...PeptideAtlasⁱ	F8VQ28.
PRIDEⁱ	F8VQ28.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029528.
ExpressionAtlasⁱ	F8VQ28. baseline and differential.
Genevisibleⁱ	F8VQ28. MM.

Interactionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
integrin binding Source: Ensembl
protein kinase binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl
vinculin binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8VQ28.
SMRⁱ	F8VQ28.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	356 – 415	LIM zinc-bindingInterPro annotationAdd BLAST	60
Domainⁱ	416 – 473	LIM zinc-bindingInterPro annotationAdd BLAST	58
Domainⁱ	474 – 533	LIM zinc-bindingInterPro annotationAdd BLAST	60
Domainⁱ	534 – 591	LIM zinc-bindingInterPro annotationAdd BLAST	58

Keywords - Domainⁱ

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1703. Eukaryota. ENOG410XRD4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910.
KEGG Orthology (KO) More...KOⁱ	K05760.
OMAⁱ	YCEAHYH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05AW.
TreeFamⁱ	TF314113.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904. Paxillin. IPR001781. Znf_LIM.
PANTHERⁱ	PTHR24216:SF32. PTHR24216:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412. LIM. 4 hits.
SMARTⁱ	View protein in SMART SM00132. LIM. 4 hits.
PROSITEⁱ	View protein in PROSITE PS00478. LIM_DOMAIN_1. 3 hits. PS50023. LIM_DOMAIN_2. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

F8VQ28-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TVLDPLDQWQ PSGSRYAHQQ PPSPLPVYSS SAKNSSASNT 
       110        120        130        140        150
QDGVGSLCSR AGEEEHVYSF PNKQKSAEPS PTVMSSSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHSPP GFPADEAESS PPLPGALSPL YGIPENNTPL GGKAGPLVKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
SQQQTRISAS SATRELDELM ASLSDFKMQG LEQRVDGERP WAASWPPSSR 
       310        320        330        340        350
QSSPEGQDEG GFMAQGKTGS SSPPGGLSKP GSQLDSMLGS LQSDLNKLGV 
       360        370        380        390        400
ATVAKGVCGA CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD 
       410        420        430        440        450
GQPYCEKDYH SLFSPRCYYC NGPILDKVVT ALDRTWHPEH FFCAQCGAFF 
       460        470        480        490        500
GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA RAILENYISA LNTLWHPECF 
       510        520        530        540        550
VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK PITGRCITAM 
       560        570        580        590 
AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQSCFVKLF C

Length:591

Mass (Da):64,506

Last modified:September 21, 2011 - v1

Checksum:ⁱF6CA5DD7F6E922DA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC159539 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_598676.2. NM_133915.3.
UniGeneⁱ	Mm.18714.

Genome annotation databases

Ensemblⁱ	ENSMUST00000086523; ENSMUSP00000083709; ENSMUSG00000029528.
GeneIDⁱ	19303.
KEGGⁱ	mmu:19303.
UCSC genome browser More...UCSCⁱ	uc008zea.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC159539 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_598676.2. NM_133915.3.
UniGeneⁱ	Mm.18714.

3D structure databases

ProteinModelPortalⁱ	F8VQ28.
SMRⁱ	F8VQ28.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F8VQ28.
PaxDbⁱ	F8VQ28.
PeptideAtlas More...PeptideAtlasⁱ	F8VQ28.
PRIDEⁱ	F8VQ28.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	19303.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000086523; ENSMUSP00000083709; ENSMUSG00000029528.
GeneIDⁱ	19303.
KEGGⁱ	mmu:19303.
UCSC genome browser More...UCSCⁱ	uc008zea.2. mouse.

Organism-specific databases

CTDⁱ	5829.
MGIⁱ	MGI:108295. Pxn.

Phylogenomic databases

eggNOGⁱ	KOG1703. Eukaryota. ENOG410XRD4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910.
KEGG Orthology (KO) More...KOⁱ	K05760.
OMAⁱ	YCEAHYH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05AW.
TreeFamⁱ	TF314113.

Miscellaneous databases

ChiTaRSⁱ	Pxn. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029528.
ExpressionAtlasⁱ	F8VQ28. baseline and differential.
Genevisibleⁱ	F8VQ28. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904. Paxillin. IPR001781. Znf_LIM.
PANTHERⁱ	PTHR24216:SF32. PTHR24216:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412. LIM. 4 hits.
SMARTⁱ	View protein in SMART SM00132. LIM. 4 hits.
PROSITEⁱ	View protein in PROSITE PS00478. LIM_DOMAIN_1. 3 hits. PS50023. LIM_DOMAIN_2. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8VQ28_MOUSE
Accessionⁱ	F8VQ28Primary (citable) accession number: F8VQ28
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	July 5, 2017
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8VQ28 (F8VQ28_MOUSE)

Your basket is currently empty.

Paxillin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ