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F8VPR5

- F8VPR5_MOUSE

UniProt

F8VPR5 - F8VPR5_MOUSE

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Protein
Submitted name: CREB-binding protein
Gene
Crebbp
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  3. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  4. acetyltransferase activity Source: MGI
  5. chromatin binding Source: MGI
  6. core promoter proximal region sequence-specific DNA binding Source: Ensembl
  7. histone acetyltransferase activity Source: MGI
  8. protein binding Source: MGI
  9. transcription coactivator activity Source: Ensembl
  10. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. N-terminal peptidyl-lysine acetylation Source: Ensembl
  2. germ-line stem cell maintenance Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_118837. Rora activates circadian gene expression.
REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198521. TRAF6 mediated IRF7 activation.
REACT_198602. PPARA activates gene expression.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.
REACT_216539. formation of the beta-catenin:TCF transactivating complex.
REACT_223626. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_223683. Notch-HLH transcription pathway.
REACT_223784. Attenuation phase.

Names & Taxonomyi

Protein namesi
Submitted name:
CREB-binding proteinImported
Gene namesi
Name:CrebbpImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1098280. Crebbp.

Subcellular locationi

GO - Cellular componenti

  1. PML body Source: MGI
  2. condensed chromosome outer kinetochore Source: MGI
  3. cytoplasm Source: Ensembl
  4. histone acetyltransferase complex Source: MGI
  5. nuclear chromatin Source: Ensembl
  6. nucleus Source: MGI
  7. transcription factor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF8VPR5.

Expressioni

Gene expression databases

ArrayExpressiF8VPR5.
BgeeiF8VPR5.

Structurei

3D structure databases

ProteinModelPortaliF8VPR5.
SMRiF8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.

Family & Domainsi

Keywords - Domaini

BromodomainSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110623.
KOiK04498.
OMAiLPNPLNM.
OrthoDBiEOG75B84F.
TreeFamiTF101097.

Family and domain databases

Gene3Di1.10.1630.10. 1 hit.
1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR010303. DUF902_CREBbp.
IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR003101. KIX_dom.
IPR009110. Nuc_rcpt_coact.
IPR014744. Nuc_rcpt_coact_CREBbp.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF09030. Creb_binding. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50952. KIX. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VPR5-1 [UniParc]FASTAAdd to Basket

« Hide

MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL     50
SLLNSGNLVP DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG 100
QAQGQPNSTN MASLGAMGKS PLNQGDSSTP NLPKQAASTS GPTPPASQAL 150
NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA 200
QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA 250
GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 300
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR 350
KLIQQQLVLL LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG 400
KACQVAHCAS SRQIISHWKN CTRHDCPVCL PLKNASDKRN QQTILGSPAS 450
GIQNTIGSVG AGQQNATSLS NPNPIDPSSM QRAYAALGLP YMNQPQTQLQ 500
PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ PPNLISESAL 550
PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 600
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY 650
HLLAEKIYKI QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV 700
RPPNGPLPLP VNRMQVSQGM NSFNPMSLGN VQLPQAPMGP RAASPMNHSV 750
QMNSMASVPG MAISPSRMPQ PPNMMGTHAN NIMAQAPTQN QFLPQNQFPS 800
SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP QASQLPCPPV 850
TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 900
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP 950
TPVHTQPPGT PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT 1000
EVQTDDAEPE PTESKGEPRS EMMEEDLQGS SQVKEETDTT EQKSEPMEVE 1050
EKKPEVKVEA KEEEENSSND TASQSTSPSQ PRKKIFKPEE LRQALMPTLE 1100
ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK RKLDTGQYQE 1150
PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 1200
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV 1250
TLGDDPSQPQ TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD 1300
IIWPSGFVCD NCLKKTGRPR KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ 1350
NHPEAGEVFV RVVASSDKTV EVKPGMKSRF VDSGEMSESF PYRTKALFAF 1400
EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF FRPRCLRTAV 1450
YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 1500
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL 1550
EESIKELEQE EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS 1600
ISRANKKKPS MPNVSNDLSQ KLYATMEKHK EVFFVIHLHA GPVISTQPPI 1650
VDPDPLLSCD LMDGRDAFLT LARDKHWEFS SLRRSKWSTL CMLVELHTQG 1700
QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT HKMVKWGLGL 1750
DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 1800
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK 1850
LRQQQIQHRL QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST 1900
PQTPQPPAQP QPSPVNMSPA GFPNVARTQP PTIVSAGKPT NQVPAPPPPA 1950
QPPPAAVEAA RQIEREAQQQ QHLYRANINN GMPPGRAGMG TPGSQMTPVG 2000
LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV MSMQAQAAVA 2050
GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 2100
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV 2150
PRPGVPPPQP AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ 2200
HQQQQQQQQQ QQQQQQNSAS LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ 2250
QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA DSTPNIQQAL QQRILQQQQM 2300
KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN QVRSPAPVQS 2350
PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 2400
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L 2441
Length:2,441
Mass (Da):265,567
Last modified:September 21, 2011 - v1
Checksum:i79A370F30FFB2A7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC132380 Genomic DNA. No translation available.
RefSeqiNP_001020603.1. NM_001025432.1.
UniGeneiMm.132238.
Mm.392384.

Genome annotation databases

EnsembliENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
GeneIDi12914.
KEGGimmu:12914.
UCSCiuc007xzl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC132380 Genomic DNA. No translation available.
RefSeqi NP_001020603.1. NM_001025432.1.
UniGenei Mm.132238.
Mm.392384.

3D structure databases

ProteinModelPortali F8VPR5.
SMRi F8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.
ModBasei Search...

Proteomic databases

PRIDEi F8VPR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023165 ; ENSMUSP00000023165 ; ENSMUSG00000022521 .
GeneIDi 12914.
KEGGi mmu:12914.
UCSCi uc007xzl.1. mouse.

Organism-specific databases

CTDi 1387.
MGIi MGI:1098280. Crebbp.

Phylogenomic databases

GeneTreei ENSGT00730000110623.
KOi K04498.
OMAi LPNPLNM.
OrthoDBi EOG75B84F.
TreeFami TF101097.

Enzyme and pathway databases

Reactomei REACT_118837. Rora activates circadian gene expression.
REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198521. TRAF6 mediated IRF7 activation.
REACT_198602. PPARA activates gene expression.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.
REACT_216539. formation of the beta-catenin:TCF transactivating complex.
REACT_223626. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_223683. Notch-HLH transcription pathway.
REACT_223784. Attenuation phase.

Miscellaneous databases

ChiTaRSi CREBBP. mouse.
NextBioi 282550.
SOURCEi Search...

Gene expression databases

ArrayExpressi F8VPR5.
Bgeei F8VPR5.

Family and domain databases

Gene3Di 1.10.1630.10. 1 hit.
1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR010303. DUF902_CREBbp.
IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR003101. KIX_dom.
IPR009110. Nuc_rcpt_coact.
IPR014744. Nuc_rcpt_coact_CREBbp.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF09030. Creb_binding. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50952. KIX. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF8VPR5_MOUSE
AccessioniPrimary (citable) accession number: F8VPR5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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