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F8VPR5 (F8VPR5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length2441 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000023165

Ontologies

Keywords
   DomainBromodomain SAAS SAAS018359
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processN-terminal peptidyl-lysine acetylation

Inferred from electronic annotation. Source: Ensembl

germ-line stem cell maintenance

Inferred from mutant phenotype PubMed 17936260. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16012757. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15464984PubMed 15509593PubMed 16145670. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12464179. Source: MGI

   Cellular_componentPML body

Inferred from sequence orthology PubMed 17332504. Source: MGI

condensed chromosome outer kinetochore

Inferred from direct assay PubMed 14519686. Source: MGI

cytoplasm

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase complex

Inferred from direct assay PubMed 9742083. Source: MGI

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 11963968PubMed 12496368PubMed 15509593. Source: MGI

transcription factor complex

Inferred from direct assay PubMed 12464179PubMed 16606840. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15681609. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription

Inferred from electronic annotation. Source: Ensembl

acetyltransferase activity

Inferred from direct assay PubMed 12496368. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15832170. Source: MGI

core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase activity

Inferred from direct assay PubMed 11115394PubMed 11867645. Source: MGI

protein binding

Inferred from physical interaction PubMed 11115394PubMed 12496368PubMed 14612417PubMed 14980219PubMed 15161102PubMed 15509593PubMed 15647252PubMed 15752756PubMed 16012757PubMed 16098148PubMed 16606840PubMed 19416967PubMed 21558372PubMed 9742083. Source: MGI

transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F8VPR5 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 79A370F30FFB2A7C

FASTA2,441265,567
        10         20         30         40         50         60 
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP 

        70         80         90        100        110        120 
DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS 

       130        140        150        160        170        180 
PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF 

       190        200        210        220        230        240 
NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE 

       250        260        270        280        290        300 
TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 

       310        320        330        340        350        360 
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL 

       370        380        390        400        410        420 
LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG KACQVAHCAS SRQIISHWKN 

       430        440        450        460        470        480 
CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM 

       490        500        510        520        530        540 
QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ 

       550        560        570        580        590        600 
PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 

       610        620        630        640        650        660 
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI 

       670        680        690        700        710        720 
QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM 

       730        740        750        760        770        780 
NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN 

       790        800        810        820        830        840 
NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP 

       850        860        870        880        890        900 
QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 

       910        920        930        940        950        960 
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT 

       970        980        990       1000       1010       1020 
PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS 

      1030       1040       1050       1060       1070       1080 
EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ 

      1090       1100       1110       1120       1130       1140 
PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK 

      1150       1160       1170       1180       1190       1200 
RKLDTGQYQE PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 

      1210       1220       1230       1240       1250       1260 
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV TLGDDPSQPQ 

      1270       1280       1290       1300       1310       1320 
TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR 

      1330       1340       1350       1360       1370       1380 
KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF 

      1390       1400       1410       1420       1430       1440 
VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF 

      1450       1460       1470       1480       1490       1500 
FRPRCLRTAV YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 

      1510       1520       1530       1540       1550       1560 
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE 

      1570       1580       1590       1600       1610       1620 
EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ 

      1630       1640       1650       1660       1670       1680 
KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS 

      1690       1700       1710       1720       1730       1740 
SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT 

      1750       1760       1770       1780       1790       1800 
HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 

      1810       1820       1830       1840       1850       1860 
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK LRQQQIQHRL 

      1870       1880       1890       1900       1910       1920 
QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA 

      1930       1940       1950       1960       1970       1980 
GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN 

      1990       2000       2010       2020       2030       2040 
GMPPGRAGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV 

      2050       2060       2070       2080       2090       2100 
MSMQAQAAVA GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 

      2110       2120       2130       2140       2150       2160 
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP 

      2170       2180       2190       2200       2210       2220 
AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS 

      2230       2240       2250       2260       2270       2280 
LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA 

      2290       2300       2310       2320       2330       2340 
DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN 

      2350       2360       2370       2380       2390       2400 
QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 

      2410       2420       2430       2440 
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC132380 Genomic DNA. No translation available.
RefSeqNP_001020603.1. NM_001025432.1.
UniGeneMm.132238.
Mm.392384.

3D structure databases

ProteinModelPortalF8VPR5.
SMRF8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF8VPR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
GeneID12914.
KEGGmmu:12914.
UCSCuc007xzl.1. mouse.

Organism-specific databases

CTD1387.
MGIMGI:1098280. Crebbp.

Phylogenomic databases

GeneTreeENSGT00730000110623.
KOK04498.
OMALPNPLNM.
OrthoDBEOG75B84F.
TreeFamTF101097.

Gene expression databases

ArrayExpressF8VPR5.
BgeeF8VPR5.

Family and domain databases

Gene3D1.10.1630.10. 1 hit.
1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR010303. DUF902_CREBbp.
IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR003101. KIX_dom.
IPR009110. Nuc_rcpt_coact.
IPR014744. Nuc_rcpt_coact_CREBbp.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF00439. Bromodomain. 1 hit.
PF09030. Creb_binding. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50952. KIX. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCREBBP. mouse.
NextBio282550.
SOURCESearch...

Entry information

Entry nameF8VPR5_MOUSE
AccessionPrimary (citable) accession number: F8VPR5
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)