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F8VPR5

- F8VPR5_MOUSE

UniProt

F8VPR5 - F8VPR5_MOUSE

Protein
Submitted name:

CREB-binding protein

Gene

Crebbp

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetyltransferase activity Source: MGI
    2. chromatin binding Source: MGI
    3. core promoter proximal region sequence-specific DNA binding Source: Ensembl
    4. DNA binding Source: MGI
    5. histone acetyltransferase activity Source: MGI
    6. protein binding Source: MGI
    7. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    8. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    9. transcription coactivator activity Source: Ensembl
    10. zinc ion binding Source: InterPro

    GO - Biological processi

    1. germ-line stem cell maintenance Source: MGI
    2. N-terminal peptidyl-lysine acetylation Source: Ensembl
    3. positive regulation of transcription, DNA-templated Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. regulation of transcription, DNA-templated Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_118837. Rora activates circadian gene expression.
    REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198521. TRAF6 mediated IRF7 activation.
    REACT_198602. PPARA activates gene expression.
    REACT_198649. Factors involved in megakaryocyte development and platelet production.
    REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.
    REACT_216539. formation of the beta-catenin:TCF transactivating complex.
    REACT_223626. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_223683. Notch-HLH transcription pathway.
    REACT_223784. Attenuation phase.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CREB-binding proteinImported
    Gene namesi
    Name:CrebbpImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1098280. Crebbp.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome outer kinetochore Source: MGI
    2. cytoplasm Source: Ensembl
    3. histone acetyltransferase complex Source: MGI
    4. nuclear chromatin Source: Ensembl
    5. nucleus Source: MGI
    6. PML body Source: MGI
    7. transcription factor complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiF8VPR5.

    Expressioni

    Gene expression databases

    ArrayExpressiF8VPR5.
    BgeeiF8VPR5.

    Structurei

    3D structure databases

    ProteinModelPortaliF8VPR5.
    SMRiF8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    BromodomainSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110623.
    KOiK04498.
    OMAiLPNPLNM.
    OrthoDBiEOG75B84F.
    TreeFamiTF101097.

    Family and domain databases

    Gene3Di1.10.1630.10. 1 hit.
    1.10.246.20. 1 hit.
    1.20.1020.10. 2 hits.
    1.20.920.10. 1 hit.
    InterProiIPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR010303. DUF902_CREBbp.
    IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR003101. KIX_dom.
    IPR009110. Nuc_rcpt_coact.
    IPR014744. Nuc_rcpt_coact_CREBbp.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF00439. Bromodomain. 1 hit.
    PF09030. Creb_binding. 1 hit.
    PF06001. DUF902. 1 hit.
    PF08214. KAT11. 1 hit.
    PF02172. KIX. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47040. SSF47040. 1 hit.
    SSF47370. SSF47370. 1 hit.
    SSF57933. SSF57933. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50952. KIX. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8VPR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL     50
    SLLNSGNLVP DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG 100
    QAQGQPNSTN MASLGAMGKS PLNQGDSSTP NLPKQAASTS GPTPPASQAL 150
    NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA 200
    QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA 250
    GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 300
    SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR 350
    KLIQQQLVLL LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG 400
    KACQVAHCAS SRQIISHWKN CTRHDCPVCL PLKNASDKRN QQTILGSPAS 450
    GIQNTIGSVG AGQQNATSLS NPNPIDPSSM QRAYAALGLP YMNQPQTQLQ 500
    PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ PPNLISESAL 550
    PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 600
    SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY 650
    HLLAEKIYKI QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV 700
    RPPNGPLPLP VNRMQVSQGM NSFNPMSLGN VQLPQAPMGP RAASPMNHSV 750
    QMNSMASVPG MAISPSRMPQ PPNMMGTHAN NIMAQAPTQN QFLPQNQFPS 800
    SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP QASQLPCPPV 850
    TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 900
    TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP 950
    TPVHTQPPGT PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT 1000
    EVQTDDAEPE PTESKGEPRS EMMEEDLQGS SQVKEETDTT EQKSEPMEVE 1050
    EKKPEVKVEA KEEEENSSND TASQSTSPSQ PRKKIFKPEE LRQALMPTLE 1100
    ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK RKLDTGQYQE 1150
    PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 1200
    CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV 1250
    TLGDDPSQPQ TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD 1300
    IIWPSGFVCD NCLKKTGRPR KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ 1350
    NHPEAGEVFV RVVASSDKTV EVKPGMKSRF VDSGEMSESF PYRTKALFAF 1400
    EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF FRPRCLRTAV 1450
    YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 1500
    QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL 1550
    EESIKELEQE EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS 1600
    ISRANKKKPS MPNVSNDLSQ KLYATMEKHK EVFFVIHLHA GPVISTQPPI 1650
    VDPDPLLSCD LMDGRDAFLT LARDKHWEFS SLRRSKWSTL CMLVELHTQG 1700
    QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT HKMVKWGLGL 1750
    DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 1800
    RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK 1850
    LRQQQIQHRL QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST 1900
    PQTPQPPAQP QPSPVNMSPA GFPNVARTQP PTIVSAGKPT NQVPAPPPPA 1950
    QPPPAAVEAA RQIEREAQQQ QHLYRANINN GMPPGRAGMG TPGSQMTPVG 2000
    LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV MSMQAQAAVA 2050
    GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 2100
    FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV 2150
    PRPGVPPPQP AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ 2200
    HQQQQQQQQQ QQQQQQNSAS LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ 2250
    QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA DSTPNIQQAL QQRILQQQQM 2300
    KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN QVRSPAPVQS 2350
    PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 2400
    NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L 2441
    Length:2,441
    Mass (Da):265,567
    Last modified:September 21, 2011 - v1
    Checksum:i79A370F30FFB2A7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132380 Genomic DNA. No translation available.
    RefSeqiNP_001020603.1. NM_001025432.1.
    UniGeneiMm.132238.
    Mm.392384.

    Genome annotation databases

    EnsembliENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
    GeneIDi12914.
    KEGGimmu:12914.
    UCSCiuc007xzl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132380 Genomic DNA. No translation available.
    RefSeqi NP_001020603.1. NM_001025432.1.
    UniGenei Mm.132238.
    Mm.392384.

    3D structure databases

    ProteinModelPortali F8VPR5.
    SMRi F8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F8VPR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023165 ; ENSMUSP00000023165 ; ENSMUSG00000022521 .
    GeneIDi 12914.
    KEGGi mmu:12914.
    UCSCi uc007xzl.1. mouse.

    Organism-specific databases

    CTDi 1387.
    MGIi MGI:1098280. Crebbp.

    Phylogenomic databases

    GeneTreei ENSGT00730000110623.
    KOi K04498.
    OMAi LPNPLNM.
    OrthoDBi EOG75B84F.
    TreeFami TF101097.

    Enzyme and pathway databases

    Reactomei REACT_118837. Rora activates circadian gene expression.
    REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198521. TRAF6 mediated IRF7 activation.
    REACT_198602. PPARA activates gene expression.
    REACT_198649. Factors involved in megakaryocyte development and platelet production.
    REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.
    REACT_216539. formation of the beta-catenin:TCF transactivating complex.
    REACT_223626. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_223683. Notch-HLH transcription pathway.
    REACT_223784. Attenuation phase.

    Miscellaneous databases

    ChiTaRSi CREBBP. mouse.
    NextBioi 282550.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi F8VPR5.
    Bgeei F8VPR5.

    Family and domain databases

    Gene3Di 1.10.1630.10. 1 hit.
    1.10.246.20. 1 hit.
    1.20.1020.10. 2 hits.
    1.20.920.10. 1 hit.
    InterProi IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR010303. DUF902_CREBbp.
    IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR003101. KIX_dom.
    IPR009110. Nuc_rcpt_coact.
    IPR014744. Nuc_rcpt_coact_CREBbp.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 1 hit.
    PF09030. Creb_binding. 1 hit.
    PF06001. DUF902. 1 hit.
    PF08214. KAT11. 1 hit.
    PF02172. KIX. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47040. SSF47040. 1 hit.
    SSF47370. SSF47370. 1 hit.
    SSF57933. SSF57933. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50952. KIX. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF8VPR5_MOUSE
    AccessioniPrimary (citable) accession number: F8VPR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3