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UniProtKB - F8VPR5 (F8VPR5_MOUSE)

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Protein
Submitted name:

CREB-binding protein

Gene

Crebbp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1494Acetyl-CoA; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei1499Acetyl-CoAPROSITE-ProRule annotation1
Binding sitei1503Acetyl-CoAPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 432TAZ-typePROSITE-ProRule annotationAdd BLAST87
Zinc fingeri1766 – 1847TAZ-typePROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionAcyltransferasePROSITE-ProRule annotation, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-2122947. NOTCH1 Intracellular Domain Regulates Transcription.
R-MMU-3134973. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
R-MMU-3371568. Attenuation phase.
R-MMU-350054. Notch-HLH transcription pathway.
R-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-MMU-5621575. CD209 (DC-SIGN) signaling.
R-MMU-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-MMU-8941856. RUNX3 regulates NOTCH signaling.
R-MMU-918233. TRAF3-dependent IRF activation pathway.
R-MMU-933541. TRAF6 mediated IRF7 activation.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
CREB-binding proteinImported
Gene namesi
Name:CrebbpImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1098280. Crebbp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiF8VPR5.
PaxDbiF8VPR5.
PeptideAtlasiF8VPR5.
PRIDEiF8VPR5.

PTM databases

iPTMnetiF8VPR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022521.
ExpressionAtlasiF8VPR5. baseline and differential.
GenevisibleiF8VPR5. MM.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

IntActiF8VPR5. 14 interactors.

Structurei

3D structure databases

ProteinModelPortaliF8VPR5.
SMRiF8VPR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 432TAZ-typeInterPro annotationAdd BLAST87
Domaini586 – 665KIXInterPro annotationAdd BLAST80
Domaini1104 – 1176BromoInterPro annotationAdd BLAST73
Domaini1324 – 1701CBP/p300-type HAT (histone acetyltransferase)InterPro annotationAdd BLAST378
Domaini1702 – 1745ZZ-typeInterPro annotationAdd BLAST44
Domaini1766 – 1847TAZ-typeInterPro annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1435 – 1437Acetyl-CoA bindingPROSITE-ProRule annotation3
Regioni1447 – 1448Acetyl-CoA bindingPROSITE-ProRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1550 – 1574Sequence analysisAdd BLAST25
Coiled coili2191 – 2216Sequence analysisAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 432TAZ-typePROSITE-ProRule annotationAdd BLAST87
Zinc fingeri1766 – 1847TAZ-typePROSITE-ProRule annotationAdd BLAST82

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1778. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
KOiK04498.
OMAiSGHSLMN.
OrthoDBiEOG091G0L04.
TreeFamiTF101097.

Family and domain databases

CDDicd15802. RING_CBP-p300. 1 hit.
Gene3Di1.10.1630.10. 1 hit.
1.20.1020.10. 3 hits.
1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR003101. KIX_dom.
IPR009110. Nuc_rcpt_coact.
IPR014744. Nuc_rcpt_coact_CREBbp.
IPR010303. RING_CBP-p300.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
PfamiView protein in Pfam
PF00439. Bromodomain. 1 hit.
PF09030. Creb_binding. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. HAT_KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiView protein in PROSITE
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51727. CBP_P300_HAT. 1 hit.
PS50952. KIX. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F8VPR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL 
        60         70         80         90        100
SLLNSGNLVP DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG 
       110        120        130        140        150
QAQGQPNSTN MASLGAMGKS PLNQGDSSTP NLPKQAASTS GPTPPASQAL 
       160        170        180        190        200
NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA 
       210        220        230        240        250
QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA 
       260        270        280        290        300
GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 
       310        320        330        340        350
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR 
       360        370        380        390        400
KLIQQQLVLL LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG 
       410        420        430        440        450
KACQVAHCAS SRQIISHWKN CTRHDCPVCL PLKNASDKRN QQTILGSPAS 
       460        470        480        490        500
GIQNTIGSVG AGQQNATSLS NPNPIDPSSM QRAYAALGLP YMNQPQTQLQ 
       510        520        530        540        550
PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ PPNLISESAL 
       560        570        580        590        600
PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 
       610        620        630        640        650
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY 
       660        670        680        690        700
HLLAEKIYKI QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV 
       710        720        730        740        750
RPPNGPLPLP VNRMQVSQGM NSFNPMSLGN VQLPQAPMGP RAASPMNHSV 
       760        770        780        790        800
QMNSMASVPG MAISPSRMPQ PPNMMGTHAN NIMAQAPTQN QFLPQNQFPS 
       810        820        830        840        850
SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP QASQLPCPPV 
       860        870        880        890        900
TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 
       910        920        930        940        950
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP 
       960        970        980        990       1000
TPVHTQPPGT PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT 
      1010       1020       1030       1040       1050
EVQTDDAEPE PTESKGEPRS EMMEEDLQGS SQVKEETDTT EQKSEPMEVE 
      1060       1070       1080       1090       1100
EKKPEVKVEA KEEEENSSND TASQSTSPSQ PRKKIFKPEE LRQALMPTLE 
      1110       1120       1130       1140       1150
ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK RKLDTGQYQE 
      1160       1170       1180       1190       1200
PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 
      1210       1220       1230       1240       1250
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV 
      1260       1270       1280       1290       1300
TLGDDPSQPQ TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD 
      1310       1320       1330       1340       1350
IIWPSGFVCD NCLKKTGRPR KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ 
      1360       1370       1380       1390       1400
NHPEAGEVFV RVVASSDKTV EVKPGMKSRF VDSGEMSESF PYRTKALFAF 
      1410       1420       1430       1440       1450
EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF FRPRCLRTAV 
      1460       1470       1480       1490       1500
YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 
      1510       1520       1530       1540       1550
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL 
      1560       1570       1580       1590       1600
EESIKELEQE EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS 
      1610       1620       1630       1640       1650
ISRANKKKPS MPNVSNDLSQ KLYATMEKHK EVFFVIHLHA GPVISTQPPI 
      1660       1670       1680       1690       1700
VDPDPLLSCD LMDGRDAFLT LARDKHWEFS SLRRSKWSTL CMLVELHTQG 
      1710       1720       1730       1740       1750
QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT HKMVKWGLGL 
      1760       1770       1780       1790       1800
DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 
      1810       1820       1830       1840       1850
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK 
      1860       1870       1880       1890       1900
LRQQQIQHRL QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST 
      1910       1920       1930       1940       1950
PQTPQPPAQP QPSPVNMSPA GFPNVARTQP PTIVSAGKPT NQVPAPPPPA 
      1960       1970       1980       1990       2000
QPPPAAVEAA RQIEREAQQQ QHLYRANINN GMPPGRAGMG TPGSQMTPVG 
      2010       2020       2030       2040       2050
LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV MSMQAQAAVA 
      2060       2070       2080       2090       2100
GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 
      2110       2120       2130       2140       2150
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV 
      2160       2170       2180       2190       2200
PRPGVPPPQP AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ 
      2210       2220       2230       2240       2250
HQQQQQQQQQ QQQQQQNSAS LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ 
      2260       2270       2280       2290       2300
QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA DSTPNIQQAL QQRILQQQQM 
      2310       2320       2330       2340       2350
KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN QVRSPAPVQS 
      2360       2370       2380       2390       2400
PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 
      2410       2420       2430       2440 
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L
Length:2,441
Mass (Da):265,567
Last modified:September 21, 2011 - v1
Checksum:i79A370F30FFB2A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132380 Genomic DNA. No translation available.
AC132575 Genomic DNA. No translation available.
RefSeqiNP_001020603.1. NM_001025432.1.
UniGeneiMm.132238.
Mm.392384.

Genome annotation databases

EnsembliENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
GeneIDi12914.
KEGGimmu:12914.
UCSCiuc007xzl.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF8VPR5_MOUSE
AccessioniPrimary (citable) accession number: F8VPR5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported