UniProtKB - F8VPR5 (F8VPR5_MOUSE)
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Protein
Submitted name:
CREB-binding protein
Gene
Crebbp
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1494 | Acetyl-CoA; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Binding sitei | 1499 | Acetyl-CoAPROSITE-ProRule annotation | 1 | |
Binding sitei | 1503 | Acetyl-CoAPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 346 – 432 | TAZ-typePROSITE-ProRule annotationAdd BLAST | 87 | |
Zinc fingeri | 1766 – 1847 | TAZ-typePROSITE-ProRule annotationAdd BLAST | 82 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- damaged DNA binding Source: Ensembl
- histone acetyltransferase activity Source: UniProtKB-UniRule
- MRF binding Source: Ensembl
- p53 binding Source: Ensembl
- proximal promoter sequence-specific DNA binding Source: Ensembl
- RNA polymerase II transcription factor binding Source: Ensembl
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
- transcriptional repressor activity, RNA polymerase II transcription factor binding Source: Ensembl
- transcription coactivator activity Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to UV Source: Ensembl
- N-terminal peptidyl-lysine acetylation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- protein destabilization Source: Ensembl
Keywordsi
Molecular function | AcyltransferasePROSITE-ProRule annotation, Transferase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-MMU-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-MMU-3371568 Attenuation phase R-MMU-350054 Notch-HLH transcription pathway R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-MMU-5621575 CD209 (DC-SIGN) signaling R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-MMU-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-MMU-8941856 RUNX3 regulates NOTCH signaling R-MMU-918233 TRAF3-dependent IRF activation pathway R-MMU-933541 TRAF6 mediated IRF7 activation R-MMU-983231 Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Submitted name: CREB-binding proteinImported |
Gene namesi | Name:CrebbpImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1098280 Crebbp |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022521 |
ExpressionAtlasi | F8VPR5 baseline and differential |
Genevisiblei | F8VPR5 MM |
Interactioni
GO - Molecular functioni
- MRF binding Source: Ensembl
- p53 binding Source: Ensembl
- RNA polymerase II transcription factor binding Source: Ensembl
Protein-protein interaction databases
IntActi | F8VPR5 14 interactors. |
Structurei
3D structure databases
ProteinModelPortali | F8VPR5 |
SMRi | F8VPR5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 346 – 432 | TAZ-typeInterPro annotationAdd BLAST | 87 | |
Domaini | 586 – 665 | KIXInterPro annotationAdd BLAST | 80 | |
Domaini | 1104 – 1176 | BromoInterPro annotationAdd BLAST | 73 | |
Domaini | 1324 – 1701 | CBP/p300-type HATInterPro annotationAdd BLAST | 378 | |
Domaini | 1702 – 1745 | ZZ-typeInterPro annotationAdd BLAST | 44 | |
Domaini | 1766 – 1847 | TAZ-typeInterPro annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1435 – 1437 | Acetyl-CoA bindingPROSITE-ProRule annotation | 3 | |
Regioni | 1447 – 1448 | Acetyl-CoA bindingPROSITE-ProRule annotation | 2 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1550 – 1574 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 2191 – 2216 | Sequence analysisAdd BLAST | 26 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 346 – 432 | TAZ-typePROSITE-ProRule annotationAdd BLAST | 87 | |
Zinc fingeri | 1766 – 1847 | TAZ-typePROSITE-ProRule annotationAdd BLAST | 82 |
Keywords - Domaini
BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG1778 Eukaryota COG5076 LUCA |
GeneTreei | ENSGT00760000119206 |
KOi | K04498 |
OMAi | SGHSLMN |
OrthoDBi | EOG091G0L04 |
TreeFami | TF101097 |
Family and domain databases
CDDi | cd15802 RING_CBP-p300, 1 hit |
Gene3Di | 1.10.1630.101 hit 1.20.1020.102 hits 1.20.920.101 hit 2.10.110.401 hit 3.30.40.101 hit |
InterProi | View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR031162 CBP_P300_HAT IPR013178 Histone_AcTrfase_Rtt109/CBP IPR003101 KIX_dom IPR036529 KIX_dom_sf IPR009110 Nuc_rcpt_coact IPR014744 Nuc_rcpt_coact_CREBbp IPR037073 Nuc_rcpt_coact_CREBbp_sf IPR010303 RING_CBP-p300 IPR038547 RING_CBP-p300_sf IPR035898 TAZ_dom_sf IPR013083 Znf_RING/FYVE/PHD IPR000197 Znf_TAZ IPR000433 Znf_ZZ |
Pfami | View protein in Pfam PF00439 Bromodomain, 1 hit PF09030 Creb_binding, 1 hit PF06001 DUF902, 1 hit PF08214 HAT_KAT11, 1 hit PF02172 KIX, 1 hit PF02135 zf-TAZ, 2 hits PF00569 ZZ, 1 hit |
PRINTSi | PR00503 BROMODOMAIN |
SMARTi | View protein in SMART SM00297 BROMO, 1 hit SM01250 KAT11, 1 hit SM00551 ZnF_TAZ, 2 hits SM00291 ZnF_ZZ, 1 hit |
SUPFAMi | SSF47040 SSF47040, 1 hit SSF47370 SSF47370, 1 hit SSF57933 SSF57933, 2 hits SSF69125 SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS51727 CBP_P300_HAT, 1 hit PS50952 KIX, 1 hit PS50134 ZF_TAZ, 2 hits PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F8VPR5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL
60 70 80 90 100
SLLNSGNLVP DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG
110 120 130 140 150
QAQGQPNSTN MASLGAMGKS PLNQGDSSTP NLPKQAASTS GPTPPASQAL
160 170 180 190 200
NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA
210 220 230 240 250
QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA
260 270 280 290 300
GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ
310 320 330 340 350
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR
360 370 380 390 400
KLIQQQLVLL LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG
410 420 430 440 450
KACQVAHCAS SRQIISHWKN CTRHDCPVCL PLKNASDKRN QQTILGSPAS
460 470 480 490 500
GIQNTIGSVG AGQQNATSLS NPNPIDPSSM QRAYAALGLP YMNQPQTQLQ
510 520 530 540 550
PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ PPNLISESAL
560 570 580 590 600
PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR
610 620 630 640 650
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY
660 670 680 690 700
HLLAEKIYKI QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV
710 720 730 740 750
RPPNGPLPLP VNRMQVSQGM NSFNPMSLGN VQLPQAPMGP RAASPMNHSV
760 770 780 790 800
QMNSMASVPG MAISPSRMPQ PPNMMGTHAN NIMAQAPTQN QFLPQNQFPS
810 820 830 840 850
SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP QASQLPCPPV
860 870 880 890 900
TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP
910 920 930 940 950
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP
960 970 980 990 1000
TPVHTQPPGT PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT
1010 1020 1030 1040 1050
EVQTDDAEPE PTESKGEPRS EMMEEDLQGS SQVKEETDTT EQKSEPMEVE
1060 1070 1080 1090 1100
EKKPEVKVEA KEEEENSSND TASQSTSPSQ PRKKIFKPEE LRQALMPTLE
1110 1120 1130 1140 1150
ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK RKLDTGQYQE
1160 1170 1180 1190 1200
PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC
1210 1220 1230 1240 1250
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV
1260 1270 1280 1290 1300
TLGDDPSQPQ TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD
1310 1320 1330 1340 1350
IIWPSGFVCD NCLKKTGRPR KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ
1360 1370 1380 1390 1400
NHPEAGEVFV RVVASSDKTV EVKPGMKSRF VDSGEMSESF PYRTKALFAF
1410 1420 1430 1440 1450
EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF FRPRCLRTAV
1460 1470 1480 1490 1500
YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL
1510 1520 1530 1540 1550
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL
1560 1570 1580 1590 1600
EESIKELEQE EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS
1610 1620 1630 1640 1650
ISRANKKKPS MPNVSNDLSQ KLYATMEKHK EVFFVIHLHA GPVISTQPPI
1660 1670 1680 1690 1700
VDPDPLLSCD LMDGRDAFLT LARDKHWEFS SLRRSKWSTL CMLVELHTQG
1710 1720 1730 1740 1750
QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT HKMVKWGLGL
1760 1770 1780 1790 1800
DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK
1810 1820 1830 1840 1850
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK
1860 1870 1880 1890 1900
LRQQQIQHRL QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST
1910 1920 1930 1940 1950
PQTPQPPAQP QPSPVNMSPA GFPNVARTQP PTIVSAGKPT NQVPAPPPPA
1960 1970 1980 1990 2000
QPPPAAVEAA RQIEREAQQQ QHLYRANINN GMPPGRAGMG TPGSQMTPVG
2010 2020 2030 2040 2050
LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV MSMQAQAAVA
2060 2070 2080 2090 2100
GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA
2110 2120 2130 2140 2150
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV
2160 2170 2180 2190 2200
PRPGVPPPQP AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ
2210 2220 2230 2240 2250
HQQQQQQQQQ QQQQQQNSAS LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ
2260 2270 2280 2290 2300
QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA DSTPNIQQAL QQRILQQQQM
2310 2320 2330 2340 2350
KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN QVRSPAPVQS
2360 2370 2380 2390 2400
PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG
2410 2420 2430 2440
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132380 Genomic DNA No translation available. AC132575 Genomic DNA No translation available. |
RefSeqi | NP_001020603.1, NM_001025432.1 |
UniGenei | Mm.132238 Mm.392384 |
Genome annotation databases
Ensembli | ENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521 |
GeneIDi | 12914 |
KEGGi | mmu:12914 |
UCSCi | uc007xzl.1 mouse |
Similar proteinsi
Entry informationi
Entry namei | F8VPR5_MOUSE | |
Accessioni | F8VPR5Primary (citable) accession number: F8VPR5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | April 25, 2018 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |