F8VPR5 (F8VPR5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CREB-binding protein Ensembl ENSMUSP00000023165

Gene names

Name:

Crebbp Ensembl ENSMUSP00000023165 MGI 1098280

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000023165

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2441 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000023165

Ontologies

Keywords
Domain	Bromodomain SAAS SAAS018359
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	N-terminal peptidyl-lysine acetylation Inferred from electronic annotation. Source: Ensembl germ-line stem cell maintenance Inferred from mutant phenotype PubMed 17936260. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 16012757. Source: MGI positive regulation of transcription, DNA-templated Inferred from direct assay PubMed 15464984PubMed 15509593PubMed 16145670. Source: MGI regulation of transcription, DNA-templated Inferred from direct assay PubMed 12464179. Source: MGI
Cellular_component	PML body Inferred from sequence orthology PubMed 17332504. Source: MGI condensed chromosome outer kinetochore Inferred from direct assay PubMed 14519686. Source: MGI cytoplasm Inferred from electronic annotation. Source: Ensembl histone acetyltransferase complex Inferred from direct assay PubMed 9742083. Source: MGI nuclear chromatin Inferred from electronic annotation. Source: Ensembl nucleus Inferred from direct assay PubMed 11963968PubMed 12496368PubMed 15509593. Source: MGI transcription factor complex Inferred from direct assay PubMed 12464179PubMed 16606840. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 15681609. Source: MGI RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Inferred from electronic annotation. Source: Ensembl RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Inferred from electronic annotation. Source: Ensembl acetyltransferase activity Inferred from direct assay PubMed 12496368. Source: MGI chromatin binding Inferred from direct assay PubMed 15832170. Source: MGI core promoter proximal region sequence-specific DNA binding Inferred from electronic annotation. Source: Ensembl histone acetyltransferase activity Inferred from direct assay PubMed 11115394PubMed 11867645. Source: MGI protein binding Inferred from physical interaction PubMed 11115394PubMed 12496368PubMed 14612417PubMed 14980219PubMed 15161102PubMed 15509593PubMed 15647252PubMed 15752756PubMed 16012757PubMed 16098148PubMed 16606840PubMed 19416967PubMed 21558372PubMed 9742083. Source: MGI transcription coactivator activity Inferred from electronic annotation. Source: Ensembl zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8VPR5 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 79A370F30FFB2A7C	FASTA	2,441	265,567
	10 20 30 40 50 60 MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP 70 80 90 100 110 120 DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS 130 140 150 160 170 180 PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF 190 200 210 220 230 240 NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE 250 260 270 280 290 300 TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 310 320 330 340 350 360 SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL 370 380 390 400 410 420 LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG KACQVAHCAS SRQIISHWKN 430 440 450 460 470 480 CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM 490 500 510 520 530 540 QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ 550 560 570 580 590 600 PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 610 620 630 640 650 660 SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI 670 680 690 700 710 720 QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM 730 740 750 760 770 780 NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN 790 800 810 820 830 840 NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP 850 860 870 880 890 900 QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 910 920 930 940 950 960 TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT 970 980 990 1000 1010 1020 PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS 1030 1040 1050 1060 1070 1080 EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ 1090 1100 1110 1120 1130 1140 PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK 1150 1160 1170 1180 1190 1200 RKLDTGQYQE PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 1210 1220 1230 1240 1250 1260 CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV TLGDDPSQPQ 1270 1280 1290 1300 1310 1320 TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR 1330 1340 1350 1360 1370 1380 KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF 1390 1400 1410 1420 1430 1440 VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF 1450 1460 1470 1480 1490 1500 FRPRCLRTAV YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 1510 1520 1530 1540 1550 1560 QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE 1570 1580 1590 1600 1610 1620 EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ 1630 1640 1650 1660 1670 1680 KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS 1690 1700 1710 1720 1730 1740 SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT 1750 1760 1770 1780 1790 1800 HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 1810 1820 1830 1840 1850 1860 RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK LRQQQIQHRL 1870 1880 1890 1900 1910 1920 QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA 1930 1940 1950 1960 1970 1980 GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN 1990 2000 2010 2020 2030 2040 GMPPGRAGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV 2050 2060 2070 2080 2090 2100 MSMQAQAAVA GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 2110 2120 2130 2140 2150 2160 FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP 2170 2180 2190 2200 2210 2220 AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS 2230 2240 2250 2260 2270 2280 LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA 2290 2300 2310 2320 2330 2340 DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN 2350 2360 2370 2380 2390 2400 QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 2410 2420 2430 2440 NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000023165.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000023165.
[3]	"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways." Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y. Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC132380 Genomic DNA. No translation available.
RefSeq	NP_001020603.1. NM_001025432.1.
UniGene	Mm.132238. Mm.392384.
3D structure databases
ProteinModelPortal	F8VPR5.
SMR	F8VPR5. Positions 340-439, 586-672, 1082-1751, 1764-1855, 2066-2112.
ModBase	Search...
MobiDB	Search...
Proteomic databases
PRIDE	F8VPR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
GeneID	12914.
KEGG	mmu:12914.
UCSC	uc007xzl.1. mouse.
Organism-specific databases
CTD	1387.
MGI	MGI:1098280. Crebbp.
Phylogenomic databases
GeneTree	ENSGT00730000110623.
KO	K04498.
OMA	LPNPLNM.
OrthoDB	EOG75B84F.
TreeFam	TF101097.
Gene expression databases
ArrayExpress	F8VPR5.
Bgee	F8VPR5.
Family and domain databases
Gene3D	1.10.1630.10. 1 hit. 1.10.246.20. 1 hit. 1.20.1020.10. 2 hits. 1.20.920.10. 1 hit.
InterPro	IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR010303. DUF902_CREBbp. IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR003101. KIX_dom. IPR009110. Nuc_rcpt_coact. IPR014744. Nuc_rcpt_coact_CREBbp. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF00439. Bromodomain. 1 hit. PF09030. Creb_binding. 1 hit. PF06001. DUF902. 1 hit. PF08214. KAT11. 1 hit. PF02172. KIX. 1 hit. PF02135. zf-TAZ. 2 hits. PF00569. ZZ. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. SM00551. ZnF_TAZ. 2 hits. SM00291. ZnF_ZZ. 1 hit. [Graphical view]
SUPFAM	SSF47040. SSF47040. 1 hit. SSF47370. SSF47370. 1 hit. SSF57933. SSF57933. 2 hits. SSF69125. SSF69125. 1 hit.
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS50952. KIX. 1 hit. PS50134. ZF_TAZ. 2 hits. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CREBBP. mouse.
NextBio	282550.
SOURCE	Search...

Entry information

Entry name

F8VPR5_MOUSE

Accession

Primary (citable) accession number: F8VPR5

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)