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F8VPQ7

- F8VPQ7_MOUSE

UniProt

F8VPQ7 - F8VPQ7_MOUSE

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Protein

Sodium channel protein

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RefGenome

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. inflammatory response Source: MGI
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: RefGenome
  5. post-embryonic development Source: MGI
  6. response to toxic substance Source: MGI
  7. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn9aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107636. Scn9a.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF8VPQ7.

Expressioni

Gene expression databases

BgeeiF8VPQ7.
ExpressionAtlasiF8VPQ7. differential.

Structurei

3D structure databases

ProteinModelPortaliF8VPQ7.
SMRiF8VPQ7. Positions 1750-1902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118827.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VPQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS
60 70 80 90 100
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF
110 120 130 140 150
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD
160 170 180 190 200
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
210 220 230 240 250
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
260 270 280 290 300
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLENGH KGYQRKCKVK
310 320 330 340 350
TMGYFYYLEG SKDALLCGFS TDSGQCPEGY ECVTAGRNPD YGYTSFDTFG
360 370 380 390 400
WAFLALFRLM TQDYWENLYQ QTLRAAGKTY MIFFVVVIFL GSFYLINLIL
410 420 430 440 450
AVVAMAYEEQ NQANIEEAKQ KELEFQQMLD RLKKEQEEAE VVFIITNTKA
460 470 480 490 500
KQVGQRIMGL SESSSETSRL SSKSAKERRN RRKKKKQKLS SGEEKGDDEK
510 520 530 540 550
LSKSGSEESI RKKSFHLGVE GHHRAREKRL STPNQSPLSI RGSLFSARRS
560 570 580 590 600
SRTSLFSFKG RGRDLGSETE FADDEHSIFG DNESRRGSLF VPHRPRERRS
610 620 630 640 650
SNISQASRSP PVLPVNGKMH SAVDCNGVVS LVDGPSALML PNGQLLPEGT
660 670 680 690 700
TNQMRKKRLS SSYFLSEDML NDPHLRQRAM SRASILTNTV EELEESRQKC
710 720 730 740 750
PPWWYRFAHT FLIWNCSPYW IKFKKFIYFI VMDPFVDLAI TICIVLNTLF
760 770 780 790 800
MAMEHHPMTD EFKNVLAVGN LVFTGIFAAE MVLKLIAMDP YEYFQVGWNI
810 820 830 840 850
FDSLIVTLSL VELFLADVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG
860 870 880 890 900
NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN ENCKLPRWHM
910 920 930 940 950
NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLIVYMM VMVIGNLVVL
960 970 980 990 1000
NLFLALLLSS FSSDNLTAIE EDTDANNLQI AVARIKRGIN YVKQTLREFI
1010 1020 1030 1040 1050
LKSFSKKPKG SKDTKRTADP NNKRENYISN RTLAEISKDH NFLKEKDKIS
1060 1070 1080 1090 1100
GFSSSLDKSF MDENDYQSFI HNPSLTVTVP IAPGESDLEN MNTEELSSDS
1110 1120 1130 1140 1150
DSDYSKERRN RSSSSECSTV DNPLPGEEEA EAEPINADEP EACFTDGCVR
1160 1170 1180 1190 1200
RFPCCQVNID SGKGKVWWTI RKTCYRIVEH SWFESFIVLM ILLSSGALAF
1210 1220 1230 1240 1250
EDIYIEKKKT IKIILEYADK IFTYIFILEM LLKWVAYGYK TYFTNAWCWL
1260 1270 1280 1290 1300
DFLIVDVSLV TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV
1310 1320 1330 1340 1350
NALIGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYECV NTTDGSRFSV
1360 1370 1380 1390 1400
SQVANRSECF ALMNVSGNVR WKNLKVNFDN VGLGYLSLLQ VATFKGWMDI
1410 1420 1430 1440 1450
MYAAVDSVNV NAQPIYEYNL YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN
1460 1470 1480 1490 1500
QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKFQGCIFDL
1510 1520 1530 1540 1550
VTNQAFDITI MVLICLNMVT MMVEKEGQTD YMSFVLYWIN VVFIILFTGE
1560 1570 1580 1590 1600
CVLKLISLRH YYFTVGWNIF DFVVVILSIV GMFLAEMIEK YFVSPTLFRV
1610 1620 1630 1640 1650
IRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF
1660 1670 1680 1690 1700
GMSNFAYVKK EAGINDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSA
1710 1720 1730 1740 1750
PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV VNMYIAVILE
1760 1770 1780 1790 1800
NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEFCK LSDFAAALDP
1810 1820 1830 1840 1850
PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS
1860 1870 1880 1890 1900
QMEERFMSAN PSKVSYEPIT TTLKRKQEDV SATIIQRAYR RYRLRQNVKN
1910 1920 1930 1940 1950
ISSIYIKDGD RDDDLPNKED IVFDNVNENS SPEKTDATAS TISPPSYDSV
1960 1970
TKPDQEKYET DKTEKEDKEK DESRK
Length:1,975
Mass (Da):225,087
Last modified:September 21, 2011 - v1
Checksum:iB63089B68F5E4210
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000100063; ENSMUSP00000097641; ENSMUSG00000075316.
UCSCiuc008jxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8VPQ7.
SMRi F8VPQ7. Positions 1750-1902.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F8VPQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100063 ; ENSMUSP00000097641 ; ENSMUSG00000075316 .
UCSCi uc008jxd.1. mouse.

Organism-specific databases

MGIi MGI:107636. Scn9a.

Phylogenomic databases

GeneTreei ENSGT00760000118827.

Miscellaneous databases

NextBioi 297959.
SOURCEi Search...

Gene expression databases

Bgeei F8VPQ7.
ExpressionAtlasi F8VPQ7. differential.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view ]
PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VPQ7_MOUSE
AccessioniPrimary (citable) accession number: F8VPQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3