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F8VPQ7

- F8VPQ7_MOUSE

UniProt

F8VPQ7 - F8VPQ7_MOUSE

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Protein

Sodium channel protein

Gene
Scn9a
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity.UniRule annotation

GO - Molecular functioni

  1. sodium ion binding Source: Ensembl
  2. voltage-gated sodium channel activity Source: RefGenome

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. inflammatory response Source: MGI
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: RefGenome
  5. post-embryonic development Source: MGI
  6. response to toxic substance Source: MGI
  7. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn9aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107636. Scn9a.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated sodium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF8VPQ7.

Expressioni

Gene expression databases

BgeeiF8VPQ7.

Structurei

3D structure databases

ProteinModelPortaliF8VPQ7.
SMRiF8VPQ7. Positions 1750-1905.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00560000076721.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VPQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLENGH KGYQRKCKVK 300
TMGYFYYLEG SKDALLCGFS TDSGQCPEGY ECVTAGRNPD YGYTSFDTFG 350
WAFLALFRLM TQDYWENLYQ QTLRAAGKTY MIFFVVVIFL GSFYLINLIL 400
AVVAMAYEEQ NQANIEEAKQ KELEFQQMLD RLKKEQEEAE VVFIITNTKA 450
KQVGQRIMGL SESSSETSRL SSKSAKERRN RRKKKKQKLS SGEEKGDDEK 500
LSKSGSEESI RKKSFHLGVE GHHRAREKRL STPNQSPLSI RGSLFSARRS 550
SRTSLFSFKG RGRDLGSETE FADDEHSIFG DNESRRGSLF VPHRPRERRS 600
SNISQASRSP PVLPVNGKMH SAVDCNGVVS LVDGPSALML PNGQLLPEGT 650
TNQMRKKRLS SSYFLSEDML NDPHLRQRAM SRASILTNTV EELEESRQKC 700
PPWWYRFAHT FLIWNCSPYW IKFKKFIYFI VMDPFVDLAI TICIVLNTLF 750
MAMEHHPMTD EFKNVLAVGN LVFTGIFAAE MVLKLIAMDP YEYFQVGWNI 800
FDSLIVTLSL VELFLADVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG 850
NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN ENCKLPRWHM 900
NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLIVYMM VMVIGNLVVL 950
NLFLALLLSS FSSDNLTAIE EDTDANNLQI AVARIKRGIN YVKQTLREFI 1000
LKSFSKKPKG SKDTKRTADP NNKRENYISN RTLAEISKDH NFLKEKDKIS 1050
GFSSSLDKSF MDENDYQSFI HNPSLTVTVP IAPGESDLEN MNTEELSSDS 1100
DSDYSKERRN RSSSSECSTV DNPLPGEEEA EAEPINADEP EACFTDGCVR 1150
RFPCCQVNID SGKGKVWWTI RKTCYRIVEH SWFESFIVLM ILLSSGALAF 1200
EDIYIEKKKT IKIILEYADK IFTYIFILEM LLKWVAYGYK TYFTNAWCWL 1250
DFLIVDVSLV TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV 1300
NALIGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYECV NTTDGSRFSV 1350
SQVANRSECF ALMNVSGNVR WKNLKVNFDN VGLGYLSLLQ VATFKGWMDI 1400
MYAAVDSVNV NAQPIYEYNL YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN 1450
QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKFQGCIFDL 1500
VTNQAFDITI MVLICLNMVT MMVEKEGQTD YMSFVLYWIN VVFIILFTGE 1550
CVLKLISLRH YYFTVGWNIF DFVVVILSIV GMFLAEMIEK YFVSPTLFRV 1600
IRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF 1650
GMSNFAYVKK EAGINDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSA 1700
PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV VNMYIAVILE 1750
NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEFCK LSDFAAALDP 1800
PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS 1850
QMEERFMSAN PSKVSYEPIT TTLKRKQEDV SATIIQRAYR RYRLRQNVKN 1900
ISSIYIKDGD RDDDLPNKED IVFDNVNENS SPEKTDATAS TISPPSYDSV 1950
TKPDQEKYET DKTEKEDKEK DESRK 1975
Length:1,975
Mass (Da):225,087
Last modified:September 21, 2011 - v1
Checksum:iB63089B68F5E4210
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000100063; ENSMUSP00000097641; ENSMUSG00000075316.
UCSCiuc008jxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F8VPQ7.
SMRi F8VPQ7. Positions 1750-1905.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F8VPQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100063 ; ENSMUSP00000097641 ; ENSMUSG00000075316 .
UCSCi uc008jxd.1. mouse.

Organism-specific databases

MGIi MGI:107636. Scn9a.

Phylogenomic databases

GeneTreei ENSGT00560000076721.

Miscellaneous databases

NextBioi 297959.
SOURCEi Search...

Gene expression databases

Bgeei F8VPQ7.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view ]
PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VPQ7_MOUSE
AccessioniPrimary (citable) accession number: F8VPQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi