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F8VPQ7

- F8VPQ7_MOUSE

UniProt

F8VPQ7 - F8VPQ7_MOUSE

Protein

Sodium channel protein

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. sodium ion binding Source: Ensembl
    2. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. behavioral response to pain Source: MGI
    2. inflammatory response Source: MGI
    3. membrane depolarization during action potential Source: RefGenome
    4. neuronal action potential Source: RefGenome
    5. post-embryonic development Source: MGI
    6. response to toxic substance Source: MGI
    7. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:Scn9aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107636. Scn9a.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: RefGenome
    2. voltage-gated sodium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiF8VPQ7.

    Expressioni

    Gene expression databases

    BgeeiF8VPQ7.

    Structurei

    3D structure databases

    ProteinModelPortaliF8VPQ7.
    SMRiF8VPQ7. Positions 1750-1902.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00560000076721.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view]
    PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8VPQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
    SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
    NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
    WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
    LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
    LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLENGH KGYQRKCKVK 300
    TMGYFYYLEG SKDALLCGFS TDSGQCPEGY ECVTAGRNPD YGYTSFDTFG 350
    WAFLALFRLM TQDYWENLYQ QTLRAAGKTY MIFFVVVIFL GSFYLINLIL 400
    AVVAMAYEEQ NQANIEEAKQ KELEFQQMLD RLKKEQEEAE VVFIITNTKA 450
    KQVGQRIMGL SESSSETSRL SSKSAKERRN RRKKKKQKLS SGEEKGDDEK 500
    LSKSGSEESI RKKSFHLGVE GHHRAREKRL STPNQSPLSI RGSLFSARRS 550
    SRTSLFSFKG RGRDLGSETE FADDEHSIFG DNESRRGSLF VPHRPRERRS 600
    SNISQASRSP PVLPVNGKMH SAVDCNGVVS LVDGPSALML PNGQLLPEGT 650
    TNQMRKKRLS SSYFLSEDML NDPHLRQRAM SRASILTNTV EELEESRQKC 700
    PPWWYRFAHT FLIWNCSPYW IKFKKFIYFI VMDPFVDLAI TICIVLNTLF 750
    MAMEHHPMTD EFKNVLAVGN LVFTGIFAAE MVLKLIAMDP YEYFQVGWNI 800
    FDSLIVTLSL VELFLADVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG 850
    NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN ENCKLPRWHM 900
    NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLIVYMM VMVIGNLVVL 950
    NLFLALLLSS FSSDNLTAIE EDTDANNLQI AVARIKRGIN YVKQTLREFI 1000
    LKSFSKKPKG SKDTKRTADP NNKRENYISN RTLAEISKDH NFLKEKDKIS 1050
    GFSSSLDKSF MDENDYQSFI HNPSLTVTVP IAPGESDLEN MNTEELSSDS 1100
    DSDYSKERRN RSSSSECSTV DNPLPGEEEA EAEPINADEP EACFTDGCVR 1150
    RFPCCQVNID SGKGKVWWTI RKTCYRIVEH SWFESFIVLM ILLSSGALAF 1200
    EDIYIEKKKT IKIILEYADK IFTYIFILEM LLKWVAYGYK TYFTNAWCWL 1250
    DFLIVDVSLV TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV 1300
    NALIGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYECV NTTDGSRFSV 1350
    SQVANRSECF ALMNVSGNVR WKNLKVNFDN VGLGYLSLLQ VATFKGWMDI 1400
    MYAAVDSVNV NAQPIYEYNL YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN 1450
    QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKFQGCIFDL 1500
    VTNQAFDITI MVLICLNMVT MMVEKEGQTD YMSFVLYWIN VVFIILFTGE 1550
    CVLKLISLRH YYFTVGWNIF DFVVVILSIV GMFLAEMIEK YFVSPTLFRV 1600
    IRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF 1650
    GMSNFAYVKK EAGINDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSA 1700
    PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV VNMYIAVILE 1750
    NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEFCK LSDFAAALDP 1800
    PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS 1850
    QMEERFMSAN PSKVSYEPIT TTLKRKQEDV SATIIQRAYR RYRLRQNVKN 1900
    ISSIYIKDGD RDDDLPNKED IVFDNVNENS SPEKTDATAS TISPPSYDSV 1950
    TKPDQEKYET DKTEKEDKEK DESRK 1975
    Length:1,975
    Mass (Da):225,087
    Last modified:September 21, 2011 - v1
    Checksum:iB63089B68F5E4210
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000100063; ENSMUSP00000097641; ENSMUSG00000075316.
    UCSCiuc008jxd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F8VPQ7.
    SMRi F8VPQ7. Positions 1750-1902.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F8VPQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100063 ; ENSMUSP00000097641 ; ENSMUSG00000075316 .
    UCSCi uc008jxd.1. mouse.

    Organism-specific databases

    MGIi MGI:107636. Scn9a.

    Phylogenomic databases

    GeneTreei ENSGT00560000076721.

    Miscellaneous databases

    NextBioi 297959.
    SOURCEi Search...

    Gene expression databases

    Bgeei F8VPQ7.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view ]
    PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF8VPQ7_MOUSE
    AccessioniPrimary (citable) accession number: F8VPQ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3