Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F8VPQ7 (F8VPQ7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length1975 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity. RuleBase RU361132

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU361132.

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification] RuleBase RU361132

Caution

Lacks conserved residue(s) required for the propagation of feature annotation. RuleBase RU361132

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000097641

Sequences

Sequence LengthMass (Da)Tools
F8VPQ7 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: B63089B68F5E4210

FASTA1,975225,087
        10         20         30         40         50         60 
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS SDLEAGKQLP 

        70         80         90        100        110        120 
FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 

       130        140        150        160        170        180 
KILVHSLFSM LIMCTILTNC IFMTMSNPPD WTKNVEYTFT GIYTFESLIK ILARGFCVGE 

       190        200        210        220        230        240 
FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 

       250        260        270        280        290        300 
SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLENGH KGYQRKCKVK 

       310        320        330        340        350        360 
TMGYFYYLEG SKDALLCGFS TDSGQCPEGY ECVTAGRNPD YGYTSFDTFG WAFLALFRLM 

       370        380        390        400        410        420 
TQDYWENLYQ QTLRAAGKTY MIFFVVVIFL GSFYLINLIL AVVAMAYEEQ NQANIEEAKQ 

       430        440        450        460        470        480 
KELEFQQMLD RLKKEQEEAE VVFIITNTKA KQVGQRIMGL SESSSETSRL SSKSAKERRN 

       490        500        510        520        530        540 
RRKKKKQKLS SGEEKGDDEK LSKSGSEESI RKKSFHLGVE GHHRAREKRL STPNQSPLSI 

       550        560        570        580        590        600 
RGSLFSARRS SRTSLFSFKG RGRDLGSETE FADDEHSIFG DNESRRGSLF VPHRPRERRS 

       610        620        630        640        650        660 
SNISQASRSP PVLPVNGKMH SAVDCNGVVS LVDGPSALML PNGQLLPEGT TNQMRKKRLS 

       670        680        690        700        710        720 
SSYFLSEDML NDPHLRQRAM SRASILTNTV EELEESRQKC PPWWYRFAHT FLIWNCSPYW 

       730        740        750        760        770        780 
IKFKKFIYFI VMDPFVDLAI TICIVLNTLF MAMEHHPMTD EFKNVLAVGN LVFTGIFAAE 

       790        800        810        820        830        840 
MVLKLIAMDP YEYFQVGWNI FDSLIVTLSL VELFLADVEG LSVLRSFRLL RVFKLAKSWP 

       850        860        870        880        890        900 
TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN ENCKLPRWHM 

       910        920        930        940        950        960 
NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLIVYMM VMVIGNLVVL NLFLALLLSS 

       970        980        990       1000       1010       1020 
FSSDNLTAIE EDTDANNLQI AVARIKRGIN YVKQTLREFI LKSFSKKPKG SKDTKRTADP 

      1030       1040       1050       1060       1070       1080 
NNKRENYISN RTLAEISKDH NFLKEKDKIS GFSSSLDKSF MDENDYQSFI HNPSLTVTVP 

      1090       1100       1110       1120       1130       1140 
IAPGESDLEN MNTEELSSDS DSDYSKERRN RSSSSECSTV DNPLPGEEEA EAEPINADEP 

      1150       1160       1170       1180       1190       1200 
EACFTDGCVR RFPCCQVNID SGKGKVWWTI RKTCYRIVEH SWFESFIVLM ILLSSGALAF 

      1210       1220       1230       1240       1250       1260 
EDIYIEKKKT IKIILEYADK IFTYIFILEM LLKWVAYGYK TYFTNAWCWL DFLIVDVSLV 

      1270       1280       1290       1300       1310       1320 
TLVANTLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV NALIGAIPSI MNVLLVCLIF 

      1330       1340       1350       1360       1370       1380 
WLIFSIMGVN LFAGKFYECV NTTDGSRFSV SQVANRSECF ALMNVSGNVR WKNLKVNFDN 

      1390       1400       1410       1420       1430       1440 
VGLGYLSLLQ VATFKGWMDI MYAAVDSVNV NAQPIYEYNL YMYIYFVIFI IFGSFFTLNL 

      1450       1460       1470       1480       1490       1500 
FIGVIIDNFN QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKFQGCIFDL 

      1510       1520       1530       1540       1550       1560 
VTNQAFDITI MVLICLNMVT MMVEKEGQTD YMSFVLYWIN VVFIILFTGE CVLKLISLRH 

      1570       1580       1590       1600       1610       1620 
YYFTVGWNIF DFVVVILSIV GMFLAEMIEK YFVSPTLFRV IRLARIGRIL RLIKGAKGIR 

      1630       1640       1650       1660       1670       1680 
TLLFALMMSL PALFNIGLLL FLVMFIYAIF GMSNFAYVKK EAGINDMFNF ETFGNSMICL 

      1690       1700       1710       1720       1730       1740 
FQITTSAGWD GLLAPILNSA PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV 

      1750       1760       1770       1780       1790       1800 
VNMYIAVILE NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEFCK LSDFAAALDP 

      1810       1820       1830       1840       1850       1860 
PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS QMEERFMSAN 

      1870       1880       1890       1900       1910       1920 
PSKVSYEPIT TTLKRKQEDV SATIIQRAYR RYRLRQNVKN ISSIYIKDGD RDDDLPNKED 

      1930       1940       1950       1960       1970 
IVFDNVNENS SPEKTDATAS TISPPSYDSV TKPDQEKYET DKTEKEDKEK DESRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalF8VPQ7.
SMRF8VPQ7. Positions 1750-1905.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF8VPQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100063; ENSMUSP00000097641; ENSMUSG00000075316.
KEGGmmu:20274.
UCSCuc008jxd.1. mouse.

Organism-specific databases

CTD6335.
MGIMGI:107636. Scn9a.

Phylogenomic databases

GeneTreeENSGT00560000076721.
KOK04841.

Gene expression databases

BgeeF8VPQ7.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSPR00170. NACHANNEL.
SMARTSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297959.
SOURCESearch...

Entry information

Entry nameF8VPQ7_MOUSE
AccessionPrimary (citable) accession number: F8VPQ7
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)