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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase kinase 4

Gene

Map4k4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase kinase 4Imported
Gene namesi
Name:Map4k4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1349394 Map4k4

PTM / Processingi

Proteomic databases

PeptideAtlasiF8VPL5
PRIDEiF8VPL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026074
ExpressionAtlasiF8VPL5 baseline and differential
GenevisibleiF8VPL5 MM

Structurei

3D structure databases

ProteinModelPortaliF8VPL5
SMRiF8VPL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 289Protein kinaseInterPro annotationAdd BLAST265
Domaini925 – 1212CNHInterPro annotationAdd BLAST288

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 379Sequence analysisAdd BLAST21
Coiled coili384 – 492Sequence analysisAdd BLAST109
Coiled coili507 – 527Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00900000140838

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

F8VPL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ
110 120 130 140 150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP
260 270 280 290 300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES
360 370 380 390 400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE
410 420 430 440 450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE
460 470 480 490 500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE ILQQQLLQEQ AMLLECRWRE
510 520 530 540 550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHAQQQPPPP QQQDRSKPSF
560 570 580 590 600
HAPEPKPHYD PADRAREVED RFRKTNHSSP EAQAKQTGRG LEPPVPSRSE
610 620 630 640 650
SFSNGNSESV HPALQRPAEP QVPVRTTSRS PVLSRRDSPL QGGGQQNSQA
660 670 680 690 700
GQRNSTSIEP RLLWERVEKL VPRPGSGSSS GSSNSGSQPG SHPGSQSGSG
710 720 730 740 750
ERFRVRSSSK SEGSPSPRQE SAAKKPDDKK EVFRPLKPAD LTALAKELRA
760 770 780 790 800
VEDVRPPHKV TDYSSSSEES GTTDEEEEDV EQEGADDSTS GPEDTRAASS
810 820 830 840 850
PNLSNGETES VKTMIVHDDV ESEPAMTPSK EGTLIVRQTQ SASSTLQKHK
860 870 880 890 900
SSSSFTPFID PRLLQISPSS GTTVTSVVGF SCDGLRPEAI RQDPTRKGSV
910 920 930 940 950
VNVNPTNTRP QSDTPEIRKY KKRFNSEILC AALWGVNLLV GTESGLMLLD
960 970 980 990 1000
RSGQGKVYPL ISRRRFQQMD VLEGLNVLVT ISGKKDKLRV YYLSWLRNKI
1010 1020 1030 1040 1050
LHNDPEVEKK QGWTTVGDLE GCVHYKVVKY ERIKFLVIAL KSSVEVYAWA
1060 1070 1080 1090 1100
PKPYHKFMAF KSFGELLHKP LLVDLTVEEG QRLKVIYGSC AGFHAVDVDS
1110 1120 1130 1140 1150
GSVYDIYLPT HIQCSIKPHA IIILPNTDGM ELLVCYEDEG VYVNTYGRIT
1160 1170 1180 1190 1200
KDVVLQWGEM PTSVAYIRSN QTMGWGEKAI EIRSVETGHL DGVFMHKRAQ
1210 1220 1230
RLKFLCERND KVFFASVRSG GSSQVYFMTL GRTSLLSW
Length:1,238
Mass (Da):141,784
Last modified:February 4, 2015 - v2
Checksum:i2487419BF47C51F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132909 Genomic DNA No translation available.
AC166238 Genomic DNA No translation available.
RefSeqiXP_006496107.1, XM_006496044.1
UniGeneiMm.491139

Genome annotation databases

EnsembliENSMUST00000168431; ENSMUSP00000129796; ENSMUSG00000026074
GeneIDi26921
UCSCiuc007atr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiF8VPL5_MOUSE
AccessioniPrimary (citable) accession number: F8VPL5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: February 4, 2015
Last modified: April 25, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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