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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase kinase 4

Gene

Map4k4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase kinase 4Imported
Gene namesi
Name:Map4k4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1349394. Map4k4.

PTM / Processingi

Proteomic databases

MaxQBiF8VPL5.
PRIDEiF8VPL5.

Expressioni

Gene expression databases

BgeeiF8VPL5.
ExpressionAtlasiF8VPL5. baseline and differential.
GenevisibleiF8VPL5. MM.

Structurei

3D structure databases

ProteinModelPortaliF8VPL5.
SMRiF8VPL5. Positions 10-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 289265Protein kinaseInterPro annotationAdd
BLAST
Domaini925 – 1212288CNHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili384 – 492109Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00810000125351.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VPL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ
110 120 130 140 150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP
260 270 280 290 300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES
360 370 380 390 400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE
410 420 430 440 450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE
460 470 480 490 500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE ILQQQLLQEQ AMLLECRWRE
510 520 530 540 550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHAQQQPPPP QQQDRSKPSF
560 570 580 590 600
HAPEPKPHYD PADRAREVED RFRKTNHSSP EAQAKQTGRG LEPPVPSRSE
610 620 630 640 650
SFSNGNSESV HPALQRPAEP QVPVRTTSRS PVLSRRDSPL QGGGQQNSQA
660 670 680 690 700
GQRNSTSIEP RLLWERVEKL VPRPGSGSSS GSSNSGSQPG SHPGSQSGSG
710 720 730 740 750
ERFRVRSSSK SEGSPSPRQE SAAKKPDDKK EVFRPLKPAD LTALAKELRA
760 770 780 790 800
VEDVRPPHKV TDYSSSSEES GTTDEEEEDV EQEGADDSTS GPEDTRAASS
810 820 830 840 850
PNLSNGETES VKTMIVHDDV ESEPAMTPSK EGTLIVRQTQ SASSTLQKHK
860 870 880 890 900
SSSSFTPFID PRLLQISPSS GTTVTSVVGF SCDGLRPEAI RQDPTRKGSV
910 920 930 940 950
VNVNPTNTRP QSDTPEIRKY KKRFNSEILC AALWGVNLLV GTESGLMLLD
960 970 980 990 1000
RSGQGKVYPL ISRRRFQQMD VLEGLNVLVT ISGKKDKLRV YYLSWLRNKI
1010 1020 1030 1040 1050
LHNDPEVEKK QGWTTVGDLE GCVHYKVVKY ERIKFLVIAL KSSVEVYAWA
1060 1070 1080 1090 1100
PKPYHKFMAF KSFGELLHKP LLVDLTVEEG QRLKVIYGSC AGFHAVDVDS
1110 1120 1130 1140 1150
GSVYDIYLPT HIQCSIKPHA IIILPNTDGM ELLVCYEDEG VYVNTYGRIT
1160 1170 1180 1190 1200
KDVVLQWGEM PTSVAYIRSN QTMGWGEKAI EIRSVETGHL DGVFMHKRAQ
1210 1220 1230
RLKFLCERND KVFFASVRSG GSSQVYFMTL GRTSLLSW
Length:1,238
Mass (Da):141,784
Last modified:February 4, 2015 - v2
Checksum:i2487419BF47C51F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132909 Genomic DNA. No translation available.
AC166238 Genomic DNA. No translation available.
RefSeqiXP_006496107.1. XM_006496044.1.
UniGeneiMm.491139.

Genome annotation databases

EnsembliENSMUST00000168431; ENSMUSP00000129796; ENSMUSG00000026074.
GeneIDi26921.
UCSCiuc007atr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132909 Genomic DNA. No translation available.
AC166238 Genomic DNA. No translation available.
RefSeqiXP_006496107.1. XM_006496044.1.
UniGeneiMm.491139.

3D structure databases

ProteinModelPortaliF8VPL5.
SMRiF8VPL5. Positions 10-311.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF8VPL5.
PRIDEiF8VPL5.

Protocols and materials databases

DNASUi26921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168431; ENSMUSP00000129796; ENSMUSG00000026074.
GeneIDi26921.
UCSCiuc007atr.1. mouse.

Organism-specific databases

CTDi9448.
MGIiMGI:1349394. Map4k4.

Phylogenomic databases

GeneTreeiENSGT00810000125351.

Miscellaneous databases

ChiTaRSiMap4k4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiF8VPL5.
ExpressionAtlasiF8VPL5. baseline and differential.
GenevisibleiF8VPL5. MM.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF8VPL5_MOUSE
AccessioniPrimary (citable) accession number: F8VPL5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: February 4, 2015
Last modified: June 8, 2016
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.