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Protein
Submitted name:

Protransforming growth factor alpha

Gene

TGFA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Protransforming growth factor alphaImported
Gene namesi
Name:TGFAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11765. TGFA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 127HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500337922425 – 166Sequence analysisAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000163235.
ExpressionAtlasiF8VNR3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF8VNR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 89EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00730000110951.
OrthoDBiEOG091G0RK4.
PhylomeDBiF8VNR3.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

F8VNR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSADP PVAAAVVSHF
60 70 80 90 100
NDCPDSHTQF CFHGTCRFLV QEDKPACVCH SGYVGARCEH ADLLAVVAAS
110 120 130 140 150
QKKQAITALV VVSIVALAVL IITCVLIHCC QVRKHCEWCR ALICRHEKPS
160
ALLKGRTACC HSETVV
Length:166
Mass (Da):17,790
Last modified:September 21, 2011 - v1
Checksum:i5557180147111D21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005234 Genomic DNA. No translation available.
AC017084 Genomic DNA. No translation available.
RefSeqiNP_001295087.1. NM_001308158.1.
UniGeneiHs.170009.
Hs.628298.

Genome annotation databases

EnsembliENST00000444975; ENSP00000404131; ENSG00000163235.
GeneIDi7039.
UCSCiuc010fdq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005234 Genomic DNA. No translation available.
AC017084 Genomic DNA. No translation available.
RefSeqiNP_001295087.1. NM_001308158.1.
UniGeneiHs.170009.
Hs.628298.

3D structure databases

ProteinModelPortaliF8VNR3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444975; ENSP00000404131; ENSG00000163235.
GeneIDi7039.
UCSCiuc010fdq.4. human.

Organism-specific databases

CTDi7039.
HGNCiHGNC:11765. TGFA.
OpenTargetsiENSG00000163235.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110951.
OrthoDBiEOG091G0RK4.
PhylomeDBiF8VNR3.

Miscellaneous databases

ChiTaRSiTGFA. human.
GenomeRNAii7039.

Gene expression databases

BgeeiENSG00000163235.
ExpressionAtlasiF8VNR3. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF8VNR3_HUMAN
AccessioniPrimary (citable) accession number: F8VNR3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 15, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.