F8VL01 (F8VL01_SALBC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphofructokinase HAMAP-Rule MF_00339
Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339

Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339

Gene names

Name:	pfkA HAMAP-Rule MF_00339 EMBL CCC32621.1
Ordered Locus Names:	SBG_3574 EMBL CCC32621.1

Organism

Salmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419) [Complete proteome] [HAMAP] EMBL CCC32621.1

Taxonomic identifier

218493 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella bongori

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. SAAS SAAS000023 HAMAP-Rule MF_00339
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. SAAS SAAS000023 HAMAP-Rule MF_00339
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00339 SAAS SAAS000023.
Sequence similarities	Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS000023 HAMAP-Rule MF_00339
Cellular component	Cytoplasm SAAS SAAS000023 HAMAP-Rule MF_00339
Ligand	ATP-binding SAAS SAAS015912 HAMAP-Rule MF_00339 RuleBase RU004092 Magnesium SAAS SAAS000023 HAMAP-Rule MF_00339 Metal-binding SAAS SAAS000023 HAMAP-Rule MF_00339 Nucleotide-binding
Molecular function	Kinase SAAS SAAS015912 HAMAP-Rule MF_00339 RuleBase RU004092 EMBL CCC32621.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	6-phosphofructokinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	22 – 26	5	ATP By similarity HAMAP-Rule MF_00339
	Nucleotide binding	155 – 159	5	ATP By similarity HAMAP-Rule MF_00339
	Nucleotide binding	172 – 188	17	ATP By similarity HAMAP-Rule MF_00339
Sites
	Active site	128	1	Proton acceptor By similarity HAMAP-Rule MF_00339
	Metal binding	186	1	Magnesium; via carbonyl oxygen By similarity HAMAP-Rule MF_00339
	Metal binding	188	1	Magnesium By similarity HAMAP-Rule MF_00339
	Binding site	163	1	Substrate By similarity HAMAP-Rule MF_00339
	Binding site	244	1	Substrate By similarity HAMAP-Rule MF_00339
	Binding site	250	1	Substrate By similarity HAMAP-Rule MF_00339
	Binding site	253	1	Substrate By similarity HAMAP-Rule MF_00339

Sequences

	Sequence		Length	Mass (Da)
	F8VL01 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 68B0DDFCF689F420	FASTA	320	34,915
	10 20 30 40 50 60 MIKKIGVLTS GGDAPGMNAA IRGVVRAALT EGLEVMGIYD GYLGLYEDRM VQLDRYSVSD 70 80 90 100 110 120 MINRGGTFLG SARFPEFRDE NIRAVAIENL KKRGIDALVV IGGDGSYMGA KRLTEMGFPC 130 140 150 160 170 180 IGLPGTIDND IKGTDYTIGY FTALGTVVEA IDRLRDTSSS HQRISIVEVM GRYCGDLTLA 190 200 210 220 230 240 AAIAGGCEFI VVPEVEFNRE DLVAEIKAGI AKGKKHAIVA ITEHMCDVDE LAHFIEKETG 250 260 270 280 290 300 RETRATVLGH IQRGGSPVPY DRILASRMGA YAIDLLLEGH GGRCVGIQNE QLVHHDIIDA 310 320 IENMKRPFKS DWMECAKKLY

References

[1]

"Salmonella bongori provides insights into the evolution of the Salmonellae." Fookes M., Schroeder G.N., Langridge G.C., Blondel C.J., Mammina C., Connor T.R., Seth-Smith H., Vernikos G.S., Robinson K.S., Sanders M., Petty N.K., Kingsley R.A., Baumler A.J., Nuccio S.P., Contreras I., Santiviago C.A., Maskell D., Barrow P. , Humphrey T., Nastasi A., Roberts M., Frankel G., Parkhill J., Dougan G., Thomson N.R. PLoS Pathog. 7:E1002191-E1002191(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43975 / DSM 13772 / NCTC 12419.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR877557 Genomic DNA. Translation: CCC32621.1.
RefSeq	YP_004732373.1. NC_015761.1.
3D structure databases
ProteinModelPortal	F8VL01.
SMR	F8VL01. Positions 1-320.
ModBase	Search...
Proteomic databases
PRIDE	F8VL01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10970805.
KEGG	sbg:SBG_3574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00850.
Enzyme and pathway databases
BioCyc	SBON218493:GJAH-3611-MONOMER.
UniPathway	UPA00109; UER00182.
Family and domain databases
HAMAP	MF_00339. Phosphofructokinase.
InterPro	IPR012003. ATP_PFK_prok. IPR012828. PFKA_ATP. IPR022953. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. IPR000023. Phosphofructokinase_dom. [Graphical view]
Pfam	PF00365. PFK. 1 hit. [Graphical view]
PIRSF	PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTS	PR00476. PHFRCTKINASE.
SUPFAM	SSF53784. Ppfruckinase. 1 hit.
TIGRFAMs	TIGR02482. PFKA_ATP. 1 hit.
PROSITE	PS00433. PHOSPHOFRUCTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F8VL01_SALBC

Accession

Primary (citable) accession number: F8VL01

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	November 28, 2012
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)