Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F8VGZ6

- F8VGZ6_SALBC

UniProt

F8VGZ6 - F8VGZ6_SALBC

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Salmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotationSAAS annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotationSAAS annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi270 – 2701Manganese 2UniRule annotation
    Metal bindingi275 – 2751Manganese 1UniRule annotation
    Metal bindingi275 – 2751Manganese 2UniRule annotation
    Active sitei282 – 2821UniRule annotation
    Metal bindingi293 – 2931Manganese 2UniRule annotation
    Metal bindingi352 – 3521Manganese 1UniRule annotation
    Metal bindingi354 – 3541Manganese 1UniRule annotation
    Metal bindingi354 – 3541Manganese 2UniRule annotation
    Active sitei356 – 3561UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminopeptidaseUniRule annotationSAAS annotationImported, Hydrolase, Protease

    Keywords - Ligandi

    ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSBON218493:GJAH-3946-MONOMER.

    Protein family/group databases

    MEROPSiM17.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:SBG_3897Imported
    OrganismiSalmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)Imported
    Taxonomic identifieri218493 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000289: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    KOiK01255.
    OMAiANEAKMS.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8VGZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG    50
    ELEGKPGQTL LLHHVPNVLS ERILLIGCGK ERELDERQYK QVIQKTINTL 100
    NDTGSMEAVC FLTELHVKGR NNYWKVRQAV ETAKETLYSF DQLKTNKSEP 150
    RRPLRKMVFN VPTRRELTSG ERAIQHGLAI AAGIKAAKDL GNMPPNICNA 200
    AYLASQARQL ADSYSTNVIT RVIGEQQMRE LGMNAYLAVG HGSQNESLMS 250
    VIEYKGNSSE EARPIVLVGK GLTFDSGGIS IKPSEGMDEM KYDMCGAAAV 300
    YGVMRMVAEL QLPINVIGVL AGCENMPGGR AYRPGDVLTT MSGQTVEVLN 350
    TDAEGRLVLC DVLTYVERFE PEAVIDVATL TGACVIALGH HITGLMSNHN 400
    PLAHELIGAS EQAGDRAWRL PLGDEYQEQL ESNFADMANI GGRPGGAITA 450
    GCFLSRFTRK YNWAHLDIAG TAWRSGKAKG ATGRPVALLA QFLLNRAGFN 500
    GEE 503
    Length:503
    Mass (Da):54,867
    Last modified:September 21, 2011 - v1
    Checksum:i4049C24FDC899C51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR877557 Genomic DNA. Translation: CCC32939.1.
    RefSeqiYP_004732681.1. NC_015761.1.

    Genome annotation databases

    EnsemblBacteriaiCCC32939; CCC32939; SBG_3897.
    GeneIDi10969183.
    KEGGisbg:SBG_3897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR877557 Genomic DNA. Translation: CCC32939.1 .
    RefSeqi YP_004732681.1. NC_015761.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M17.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC32939 ; CCC32939 ; SBG_3897 .
    GeneIDi 10969183.
    KEGGi sbg:SBG_3897.

    Phylogenomic databases

    KOi K01255.
    OMAi ANEAKMS.

    Enzyme and pathway databases

    BioCyci SBON218493:GJAH-3946-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43975 / DSM 13772 / NCTC 12419Imported.

    Entry informationi

    Entry nameiF8VGZ6_SALBC
    AccessioniPrimary (citable) accession number: F8VGZ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3