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F8VGZ6

- F8VGZ6_SALBC

UniProt

F8VGZ6 - F8VGZ6_SALBC

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Protein
Probable cytosol aminopeptidase
Gene
pepA, SBG_3897
Organism
Salmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotationSAAS annotations
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi270 – 2701Manganese 2 By similarityUniRule annotation
Metal bindingi275 – 2751Manganese 1 By similarityUniRule annotation
Metal bindingi275 – 2751Manganese 2 By similarityUniRule annotation
Active sitei282 – 2821 By similarityUniRule annotation
Metal bindingi293 – 2931Manganese 2 By similarityUniRule annotation
Metal bindingi352 – 3521Manganese 1 By similarityUniRule annotation
Metal bindingi354 – 3541Manganese 1 By similarityUniRule annotation
Metal bindingi354 – 3541Manganese 2 By similarityUniRule annotation
Active sitei356 – 3561 By similarityUniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminopeptidaseUniRule annotationSAAS annotationsImported, Hydrolase, Protease

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSBON218493:GJAH-3946-MONOMER.

Protein family/group databases

MEROPSiM17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidase
Leucyl aminopeptidase
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:SBG_3897Imported
OrganismiSalmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)Imported
Taxonomic identifieri218493 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000289: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

KOiK01255.
OMAiANEAKMS.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8VGZ6-1 [UniParc]FASTAAdd to Basket

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MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG    50
ELEGKPGQTL LLHHVPNVLS ERILLIGCGK ERELDERQYK QVIQKTINTL 100
NDTGSMEAVC FLTELHVKGR NNYWKVRQAV ETAKETLYSF DQLKTNKSEP 150
RRPLRKMVFN VPTRRELTSG ERAIQHGLAI AAGIKAAKDL GNMPPNICNA 200
AYLASQARQL ADSYSTNVIT RVIGEQQMRE LGMNAYLAVG HGSQNESLMS 250
VIEYKGNSSE EARPIVLVGK GLTFDSGGIS IKPSEGMDEM KYDMCGAAAV 300
YGVMRMVAEL QLPINVIGVL AGCENMPGGR AYRPGDVLTT MSGQTVEVLN 350
TDAEGRLVLC DVLTYVERFE PEAVIDVATL TGACVIALGH HITGLMSNHN 400
PLAHELIGAS EQAGDRAWRL PLGDEYQEQL ESNFADMANI GGRPGGAITA 450
GCFLSRFTRK YNWAHLDIAG TAWRSGKAKG ATGRPVALLA QFLLNRAGFN 500
GEE 503
Length:503
Mass (Da):54,867
Last modified:September 21, 2011 - v1
Checksum:i4049C24FDC899C51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR877557 Genomic DNA. Translation: CCC32939.1.
RefSeqiYP_004732681.1. NC_015761.1.

Genome annotation databases

EnsemblBacteriaiCCC32939; CCC32939; SBG_3897.
GeneIDi10969183.
KEGGisbg:SBG_3897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR877557 Genomic DNA. Translation: CCC32939.1 .
RefSeqi YP_004732681.1. NC_015761.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M17.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC32939 ; CCC32939 ; SBG_3897 .
GeneIDi 10969183.
KEGGi sbg:SBG_3897.

Phylogenomic databases

KOi K01255.
OMAi ANEAKMS.

Enzyme and pathway databases

BioCyci SBON218493:GJAH-3946-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43975 / DSM 13772 / NCTC 12419.

Entry informationi

Entry nameiF8VGZ6_SALBC
AccessioniPrimary (citable) accession number: F8VGZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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