Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F8VGZ6 (F8VGZ6_SALBC) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable cytosol aminopeptidase HAMAP-Rule MF_00181

EC=3.4.11.1 HAMAP-Rule MF_00181
Alternative name(s):
Leucine aminopeptidase HAMAP-Rule MF_00181
Leucyl aminopeptidase HAMAP-Rule MF_00181
Gene names
Name:pepA HAMAP-Rule MF_00181
Ordered Locus Names:SBG_3897 EMBL CCC32939.1
OrganismSalmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419) [Complete proteome] [HAMAP] EMBL CCC32939.1
Taxonomic identifier218493 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity. SAAS SAAS011356 HAMAP-Rule MF_00181

Catalytic activity

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. SAAS SAAS011356 HAMAP-Rule MF_00181

Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. HAMAP-Rule MF_00181

Cofactor

Binds 2 manganese ions per subunit By similarity. HAMAP-Rule MF_00181

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00181 SAAS SAAS011356.

Sequence similarities

Belongs to the peptidase M17 family. HAMAP-Rule MF_00181

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2821 By similarity HAMAP-Rule MF_00181
Active site3561 By similarity HAMAP-Rule MF_00181
Metal binding2701Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding2751Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding2751Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding2931Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding3521Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding3541Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding3541Manganese 2 By similarity HAMAP-Rule MF_00181

Sequences

Sequence LengthMass (Da)Tools
F8VGZ6 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 4049C24FDC899C51

FASTA50354,867
        10         20         30         40         50         60 
MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG ELEGKPGQTL 

        70         80         90        100        110        120 
LLHHVPNVLS ERILLIGCGK ERELDERQYK QVIQKTINTL NDTGSMEAVC FLTELHVKGR 

       130        140        150        160        170        180 
NNYWKVRQAV ETAKETLYSF DQLKTNKSEP RRPLRKMVFN VPTRRELTSG ERAIQHGLAI 

       190        200        210        220        230        240 
AAGIKAAKDL GNMPPNICNA AYLASQARQL ADSYSTNVIT RVIGEQQMRE LGMNAYLAVG 

       250        260        270        280        290        300 
HGSQNESLMS VIEYKGNSSE EARPIVLVGK GLTFDSGGIS IKPSEGMDEM KYDMCGAAAV 

       310        320        330        340        350        360 
YGVMRMVAEL QLPINVIGVL AGCENMPGGR AYRPGDVLTT MSGQTVEVLN TDAEGRLVLC 

       370        380        390        400        410        420 
DVLTYVERFE PEAVIDVATL TGACVIALGH HITGLMSNHN PLAHELIGAS EQAGDRAWRL 

       430        440        450        460        470        480 
PLGDEYQEQL ESNFADMANI GGRPGGAITA GCFLSRFTRK YNWAHLDIAG TAWRSGKAKG 

       490        500 
ATGRPVALLA QFLLNRAGFN GEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR877557 Genomic DNA. Translation: CCC32939.1.
RefSeqYP_004732681.1. NC_015761.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM17.003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10969183.
KEGGsbg:SBG_3897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01255.
OMAESLMSVM.

Enzyme and pathway databases

BioCycSBON218493:GJAH-3946-MONOMER.

Family and domain databases

HAMAPMF_00181. Cytosol_peptidase_M17.
InterProIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERPTHR11963:SF3. PTHR11963:SF3. 1 hit.
PfamPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSPR00481. LAMNOPPTDASE.
PROSITEPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8VGZ6_SALBC
AccessionPrimary (citable) accession number: F8VGZ6
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)