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F8UU09

- F8UU09_9INFA

UniProt

F8UU09 - F8UU09_9INFA

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Protein
Submitted name:

Neuraminidase

Gene
NA
Organism
Influenza A virus (A/Netherlands/2631_1202/2010(H1N1))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501Phosphate 1
Binding sitei199 – 1991Phosphate 1; via amide nitrogen
Binding sitei293 – 2931Phosphate 2
Metal bindingi294 – 2941Calcium; via carbonyl oxygenImported
Metal bindingi298 – 2981Calcium; via carbonyl oxygenImported
Metal bindingi324 – 3241CalciumImported
Metal bindingi342 – 3421Calcium; via carbonyl oxygenImported
Metal bindingi344 – 3441Calcium; via carbonyl oxygenImported
Binding sitei368 – 3681Phosphate 2
Binding sitei402 – 4021Phosphate 2
Binding sitei455 – 4551Phosphate 1

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotations, Hydrolase

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
NeuraminidaseImported
Gene namesi
Name:NAImported
OrganismiInfluenza A virus (A/Netherlands/2631_1202/2010(H1N1))Imported
Taxonomic identifieri1027873 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, VirionSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)
Glycosylationi146 – 1461N-linked (GlcNAc...)
Glycosylationi235 – 2351N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.SAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B7JX-ray2.42A1-469[»]
4B7MX-ray2.50A/B1-469[»]
4B7NX-ray2.84A1-469[»]

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

F8UU09-1 [UniParc]FASTAAdd to Basket

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MNPNQKIITI GSVCMTIGMA NLILQIGNII SIWISHSIQL GNQNQIETCN    50
QSVITYENNT WVNQTYVNIS NTNFAAGQSV VSVKLAGNSS LCPVSGWAIY 100
SKDNSIRIGS KGDVFVIREP FISCSPLECR TFFLTQGALL NDKHSNGTIK 150
DRSPYRTLMS CPIGEVPSPY NSRFESVAWS ASACHDGINW LTIGISGPDN 200
GAVAVLKYNG IITDTIKSWR NNRLRTQESE CACVNGSCFT VMTDGPSDGQ 250
ASYKIFRIEK GKIVKSVEMN APNYHYEECS CYPDSSEITC VCRDNWHGSN 300
RPWVSFNQNL EYQIGYICSG IFGDNPRPND KTGSCGPVSS NGANGVKGFS 350
FKYGNGVWIG RTKSISSRNG FEMIWDPNGW TGTDNDFSIK QDIVGINEWS 400
GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PKENTIWTSG SSISFCGVNS 450
DTVGWSWPDG AELPFTIDK 469
Length:469
Mass (Da):51,656
Last modified:September 21, 2011 - v1
Checksum:i48F0F60CD8119D39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF906185 Viral cRNA. Translation: AEE69001.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF906185 Viral cRNA. Translation: AEE69001.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B7J X-ray 2.42 A 1-469 [» ]
4B7M X-ray 2.50 A/B 1-469 [» ]
4B7N X-ray 2.84 A 1-469 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00064. Neur. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Multidrug Resistant 2009 A/H1N1 Influenza Clinical Isolate with a Neuraminidase I223R Mutation Retains Its Virulence and Transmissibility in Ferrets."
    van der Vries E., Veldhuis Kroeze E.J., Stittelaar K.J., Linster M., Van der Linden A., Schrauwen E.J., Leijten L.M., van Amerongen G., Schutten M., Kuiken T., Osterhaus A.D., Fouchier R.A., Boucher C.A., Herfst S.
    PLoS Pathog. 7:E1002276-E1002276(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Netherlands/2631_1202/2010Imported.
  2. "H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis."
    van der Vries E., Collins P.J., Vachieri S.G., Xiong X., Liu J., Walker P.A., Haire L.F., Hay A.J., Schutten M., Osterhaus A.D., Martin S.R., Boucher C.A., Skehel J.J., Gamblin S.J.
    PLoS Pathog. 8:e1002914-e1002914(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) IN COMPLEX WITH CALCIUM AND PHOSPHATE, GLYCOSYLATION AT ASN-88; ASN-146 AND ASN-235.

Entry informationi

Entry nameiF8UU09_9INFA
AccessioniPrimary (citable) accession number: F8UU09
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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