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F8UU09 (F8UU09_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SAAS SAAS001860

Subunit structure

Homotetramer By similarity. SAAS SAAS001860

Subcellular location

Virion membrane. Host apical cell membrane; Single-pass type II membrane protein By similarity SAAS SAAS001860.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2941Calcium; via carbonyl oxygen PDB 4B7J PDB 4B7M PDB 4B7N
Metal binding2981Calcium; via carbonyl oxygen PDB 4B7J PDB 4B7M PDB 4B7N
Metal binding3241Calcium PDB 4B7J PDB 4B7M PDB 4B7N
Metal binding3421Calcium; via carbonyl oxygen PDB 4B7J PDB 4B7M PDB 4B7N
Metal binding3441Calcium; via carbonyl oxygen PDB 4B7J PDB 4B7M PDB 4B7N
Binding site1501Phosphate 1
Binding site1991Phosphate 1; via amide nitrogen
Binding site2931Phosphate 2
Binding site3681Phosphate 2
Binding site4021Phosphate 2
Binding site4551Phosphate 1

Amino acid modifications

Glycosylation881N-linked (GlcNAc...)
Glycosylation1461N-linked (GlcNAc...)
Glycosylation2351N-linked (GlcNAc...)

Sequences

Sequence LengthMass (Da)Tools
F8UU09 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 48F0F60CD8119D39

FASTA46951,656
        10         20         30         40         50         60 
MNPNQKIITI GSVCMTIGMA NLILQIGNII SIWISHSIQL GNQNQIETCN QSVITYENNT 

        70         80         90        100        110        120 
WVNQTYVNIS NTNFAAGQSV VSVKLAGNSS LCPVSGWAIY SKDNSIRIGS KGDVFVIREP 

       130        140        150        160        170        180 
FISCSPLECR TFFLTQGALL NDKHSNGTIK DRSPYRTLMS CPIGEVPSPY NSRFESVAWS 

       190        200        210        220        230        240 
ASACHDGINW LTIGISGPDN GAVAVLKYNG IITDTIKSWR NNRLRTQESE CACVNGSCFT 

       250        260        270        280        290        300 
VMTDGPSDGQ ASYKIFRIEK GKIVKSVEMN APNYHYEECS CYPDSSEITC VCRDNWHGSN 

       310        320        330        340        350        360 
RPWVSFNQNL EYQIGYICSG IFGDNPRPND KTGSCGPVSS NGANGVKGFS FKYGNGVWIG 

       370        380        390        400        410        420 
RTKSISSRNG FEMIWDPNGW TGTDNDFSIK QDIVGINEWS GYSGSFVQHP ELTGLDCIRP 

       430        440        450        460 
CFWVELIRGR PKENTIWTSG SSISFCGVNS DTVGWSWPDG AELPFTIDK 

« Hide

References

[1]"Multidrug Resistant 2009 A/H1N1 Influenza Clinical Isolate with a Neuraminidase I223R Mutation Retains Its Virulence and Transmissibility in Ferrets."
van der Vries E., Veldhuis Kroeze E.J., Stittelaar K.J., Linster M., Van der Linden A., Schrauwen E.J., Leijten L.M., van Amerongen G., Schutten M., Kuiken T., Osterhaus A.D., Fouchier R.A., Boucher C.A., Herfst S.
PLoS Pathog. 7:E1002276-E1002276(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/Netherlands/2631_1202/2010 EMBL AEE69001.1.
[2]"H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis."
van der Vries E., Collins P.J., Vachieri S.G., Xiong X., Liu J., Walker P.A., Haire L.F., Hay A.J., Schutten M., Osterhaus A.D., Martin S.R., Boucher C.A., Skehel J.J., Gamblin S.J.
PLoS Pathog. 8:e1002914-e1002914(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) IN COMPLEX WITH CALCIUM AND PHOSPHATE, GLYCOSYLATION AT ASN-88; ASN-146 AND ASN-235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JF906185 Viral cRNA. Translation: AEE69001.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B7JX-ray2.42A1-469[»]
4B7MX-ray2.50A/B1-469[»]
4B7NX-ray2.84A1-469[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF8UU09_9INFA
AccessionPrimary (citable) accession number: F8UU09
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)