F8M936 (F8M936_MYCA0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Name:	ask EMBL CCC28787.1
Ordered Locus Names:	MAF_37180 EMBL CCC28787.1

Organism

Mycobacterium africanum (strain GM041182) [Complete proteome] [HAMAP] EMBL CCC28787.1

Taxonomic identifier

572418 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium africanum

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate. RuleBase RU003448
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. RuleBase RU004249 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. RuleBase RU004249 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. RuleBase RU004249
Sequence similarities	Belongs to the aspartokinase family. RuleBase RU003448

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 EMBL CCC28787.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: UniProtKB-UniPathway threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8M936 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 0567323B0D2085A7	FASTA	421	44,462
	10 20 30 40 50 60 MALVVQKYGG SSVADAERIR RVAERIVATK KQGNDVVVVV SAMGDTTDDL LDLAQQVCPA 70 80 90 100 110 120 PPPRELDMLL TAGERISNAL VAMAIESLGA HARSFTGSQA GVITTGTHGN AKIIDVTPGR 130 140 150 160 170 180 LQTALEEGRV VLVAGFQGVS QDTKDVTTLG RGGSDTTAVA MAAALGADVC EIYTDVDGIF 190 200 210 220 230 240 SADPRIVRNA RKLDTVTFEE MLEMAACGAK VLMLRCVEYA RRHNIPVHVR SSYSDRPGTV 250 260 270 280 290 300 VVGSIKDVPM EDPILTGVAH DRSEAKVTIV GLPDIPGYAA KVFRAVADAD VNIDMVLQNV 310 320 330 340 350 360 SKVEDGKTDI TFTCSRDVGP AAVEKLDSLR NEIGFSQLLY DDHIGKVSLI GAGMRSHPGV 370 380 390 400 410 420 TATFCEALAA VGVNIELIST SEIRISVLCR DTELDKAVVA LHEAFGLGGD EEATVYAGTG R

References

[1]

"The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and features of genome erosion shared with other members of the tuberculosis complex." Bentley S.D., Comas I., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., De Jong B.C. Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GM041182.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR878060 Genomic DNA. Translation: CCC28787.1.
RefSeq	YP_004725343.1. NC_015758.1.
3D structure databases
ProteinModelPortal	F8M936.
SMR	F8M936. Positions 1-409.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCC28787; CCC28787; MAF_37180.
GeneID	10957045.
KEGG	maf:MAF_37180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00928.
Enzyme and pathway databases
BioCyc	MAFR572418:GJCK-3741-MONOMER.
UniPathway	UPA00034; UER00015. UPA00050; UER00461. UPA00051; UER00462.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
InterPro	IPR002912. ACT_dom. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00656. asp_kin_monofn. 1 hit. TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F8M936_MYCA0

Accession

Primary (citable) accession number: F8M936

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)