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F8M859

- F8M859_MYCA0

UniProt

F8M859 - F8M859_MYCA0

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Protein
Quinolinate synthase A
Gene
nadA, MAF_16060
Organism
Mycobacterium africanum (strain GM041182)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Iminoaspartate By similarityUniRule annotation
Binding sitei69 – 691Iminoaspartate; via amide nitrogen By similarityUniRule annotation
Binding sitei140 – 1401Iminoaspartate By similarityUniRule annotation
Binding sitei157 – 1571Iminoaspartate By similarityUniRule annotation
Binding sitei227 – 2271Iminoaspartate By similarityUniRule annotation
Binding sitei255 – 2551Iminoaspartate By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMAFR572418:GJCK-1622-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotationImported
Ordered Locus Names:MAF_16060Imported
OrganismiMycobacterium africanum (strain GM041182)Imported
Taxonomic identifieri572418 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000298: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8M859.
SMRiF8M859. Positions 32-342.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK03517.

Family and domain databases

HAMAPiMF_00568. NadA_type2.
InterProiIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

F8M859-1 [UniParc]FASTAAdd to Basket

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MTVLNRTDTL VDELTADITN TPLGYGGVDG DERWAAEIRR LAHLRGATVL    50
AHNYQLPAIQ DVADHVGDSL ALSRVAAEAP EDTIVFCGVH FMAETAKILS 100
PHKTVLIPDQ RAGCSLADSI TPDELRAWKD EHPGAVVVSY VNTTAAVKAL 150
TDICCTSSNA VDVVASIDPD REVLFCPDQF LGAHVRRVTG RKNLHVWAGE 200
CHVHAGINGD ELADQARAHP DAELFVHPEC GCATSALYLA GEGAFPAERV 250
KILSTGGMLE AAHTTRARQV LVATEVGMLH QLRRAAPEVD FRAVNDRASC 300
KYMKMITPAA LLRCLVEGAD EVHVDPGIAA SGRRSVQRMI EIGHPGGGE 349
Length:349
Mass (Da):37,408
Last modified:September 21, 2011 - v1
Checksum:i3053D1945CBE5288
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR878060 Genomic DNA. Translation: CCC26678.1.
RefSeqiYP_004723292.1. NC_015758.1.

Genome annotation databases

EnsemblBacteriaiCCC26678; CCC26678; MAF_16060.
GeneIDi10955608.
KEGGimaf:MAF_16060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR878060 Genomic DNA. Translation: CCC26678.1 .
RefSeqi YP_004723292.1. NC_015758.1.

3D structure databases

ProteinModelPortali F8M859.
SMRi F8M859. Positions 32-342.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC26678 ; CCC26678 ; MAF_16060 .
GeneIDi 10955608.
KEGGi maf:MAF_16060.

Phylogenomic databases

KOi K03517.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci MAFR572418:GJCK-1622-MONOMER.

Family and domain databases

HAMAPi MF_00568. NadA_type2.
InterProi IPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex."
    Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., de Jong B.C.
    PLoS Negl. Trop. Dis. 6:E1552-E1552(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GM041182Imported.

Entry informationi

Entry nameiF8M859_MYCA0
AccessioniPrimary (citable) accession number: F8M859
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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