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F8M859

- F8M859_MYCA0

UniProt

F8M859 - F8M859_MYCA0

Protein

Quinolinate synthase A

Gene

nadA

Organism
Mycobacterium africanum (strain GM041182)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521IminoaspartateUniRule annotation
    Binding sitei69 – 691Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei140 – 1401IminoaspartateUniRule annotation
    Binding sitei157 – 1571IminoaspartateUniRule annotation
    Binding sitei227 – 2271IminoaspartateUniRule annotation
    Binding sitei255 – 2551IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciMAFR572418:GJCK-1622-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotationImported
    Ordered Locus Names:MAF_16060Imported
    OrganismiMycobacterium africanum (strain GM041182)Imported
    Taxonomic identifieri572418 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000000298: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8M859.
    SMRiF8M859. Positions 32-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK03517.

    Family and domain databases

    HAMAPiMF_00568. NadA_type2.
    InterProiIPR003473. NadA.
    IPR023066. Quinolinate_synth_type2.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8M859-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVLNRTDTL VDELTADITN TPLGYGGVDG DERWAAEIRR LAHLRGATVL    50
    AHNYQLPAIQ DVADHVGDSL ALSRVAAEAP EDTIVFCGVH FMAETAKILS 100
    PHKTVLIPDQ RAGCSLADSI TPDELRAWKD EHPGAVVVSY VNTTAAVKAL 150
    TDICCTSSNA VDVVASIDPD REVLFCPDQF LGAHVRRVTG RKNLHVWAGE 200
    CHVHAGINGD ELADQARAHP DAELFVHPEC GCATSALYLA GEGAFPAERV 250
    KILSTGGMLE AAHTTRARQV LVATEVGMLH QLRRAAPEVD FRAVNDRASC 300
    KYMKMITPAA LLRCLVEGAD EVHVDPGIAA SGRRSVQRMI EIGHPGGGE 349
    Length:349
    Mass (Da):37,408
    Last modified:September 21, 2011 - v1
    Checksum:i3053D1945CBE5288
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR878060 Genomic DNA. Translation: CCC26678.1.
    RefSeqiYP_004723292.1. NC_015758.1.

    Genome annotation databases

    EnsemblBacteriaiCCC26678; CCC26678; MAF_16060.
    GeneIDi10955608.
    KEGGimaf:MAF_16060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR878060 Genomic DNA. Translation: CCC26678.1 .
    RefSeqi YP_004723292.1. NC_015758.1.

    3D structure databases

    ProteinModelPortali F8M859.
    SMRi F8M859. Positions 32-342.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC26678 ; CCC26678 ; MAF_16060 .
    GeneIDi 10955608.
    KEGGi maf:MAF_16060.

    Phylogenomic databases

    KOi K03517.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci MAFR572418:GJCK-1622-MONOMER.

    Family and domain databases

    HAMAPi MF_00568. NadA_type2.
    InterProi IPR003473. NadA.
    IPR023066. Quinolinate_synth_type2.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex."
      Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., de Jong B.C.
      PLoS Negl. Trop. Dis. 6:E1552-E1552(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GM041182Imported.

    Entry informationi

    Entry nameiF8M859_MYCA0
    AccessioniPrimary (citable) accession number: F8M859
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3