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Protein

Quinolinate synthase A

Gene

nadA

Organism
Mycobacterium africanum (strain GM041182)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52IminoaspartateUniRule annotation1
Binding sitei69Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei140IminoaspartateUniRule annotation1
Binding sitei157IminoaspartateUniRule annotation1
Binding sitei227IminoaspartateUniRule annotation1
Binding sitei255IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotationImported
Ordered Locus Names:MAF_16060Imported
OrganismiMycobacterium africanum (strain GM041182)Imported
Taxonomic identifieri572418 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000000298 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8M859
SMRiF8M859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK03517
OMAiLWAPDRH

Family and domain databases

HAMAPiMF_00568 NadA_type2, 1 hit
InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
IPR023066 Quinolinate_synth_type2
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

F8M859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLNRTDTL VDELTADITN TPLGYGGVDG DERWAAEIRR LAHLRGATVL
60 70 80 90 100
AHNYQLPAIQ DVADHVGDSL ALSRVAAEAP EDTIVFCGVH FMAETAKILS
110 120 130 140 150
PHKTVLIPDQ RAGCSLADSI TPDELRAWKD EHPGAVVVSY VNTTAAVKAL
160 170 180 190 200
TDICCTSSNA VDVVASIDPD REVLFCPDQF LGAHVRRVTG RKNLHVWAGE
210 220 230 240 250
CHVHAGINGD ELADQARAHP DAELFVHPEC GCATSALYLA GEGAFPAERV
260 270 280 290 300
KILSTGGMLE AAHTTRARQV LVATEVGMLH QLRRAAPEVD FRAVNDRASC
310 320 330 340
KYMKMITPAA LLRCLVEGAD EVHVDPGIAA SGRRSVQRMI EIGHPGGGE
Length:349
Mass (Da):37,408
Last modified:September 21, 2011 - v1
Checksum:i3053D1945CBE5288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR878060 Genomic DNA Translation: CCC26678.1
RefSeqiWP_003407931.1, NC_015758.1

Genome annotation databases

EnsemblBacteriaiCCC26678; CCC26678; MAF_16060
KEGGimaf:MAF_16060

Similar proteinsi

Entry informationi

Entry nameiF8M859_MYCA0
AccessioniPrimary (citable) accession number: F8M859
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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