Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F8M859 (F8M859_MYCA0) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity. SAAS SAAS003473 HAMAP-Rule MF_00568

Catalytic activity

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate. SAAS SAAS003473 HAMAP-Rule MF_00568

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP-Rule MF_00568

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. SAAS SAAS003473 HAMAP-Rule MF_00568

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00568.

Sequence similarities

Belongs to the quinolinate synthase A family. Type 2 subfamily. HAMAP-Rule MF_00568

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site521Iminoaspartate By similarity HAMAP-Rule MF_00568
Binding site691Iminoaspartate; via amide nitrogen By similarity HAMAP-Rule MF_00568
Binding site1401Iminoaspartate By similarity HAMAP-Rule MF_00568
Binding site1571Iminoaspartate By similarity HAMAP-Rule MF_00568
Binding site2271Iminoaspartate By similarity HAMAP-Rule MF_00568
Binding site2551Iminoaspartate By similarity HAMAP-Rule MF_00568

Sequences

Sequence LengthMass (Da)Tools
F8M859 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 3053D1945CBE5288

FASTA34937,408
        10         20         30         40         50         60 
MTVLNRTDTL VDELTADITN TPLGYGGVDG DERWAAEIRR LAHLRGATVL AHNYQLPAIQ 

        70         80         90        100        110        120 
DVADHVGDSL ALSRVAAEAP EDTIVFCGVH FMAETAKILS PHKTVLIPDQ RAGCSLADSI 

       130        140        150        160        170        180 
TPDELRAWKD EHPGAVVVSY VNTTAAVKAL TDICCTSSNA VDVVASIDPD REVLFCPDQF 

       190        200        210        220        230        240 
LGAHVRRVTG RKNLHVWAGE CHVHAGINGD ELADQARAHP DAELFVHPEC GCATSALYLA 

       250        260        270        280        290        300 
GEGAFPAERV KILSTGGMLE AAHTTRARQV LVATEVGMLH QLRRAAPEVD FRAVNDRASC 

       310        320        330        340 
KYMKMITPAA LLRCLVEGAD EVHVDPGIAA SGRRSVQRMI EIGHPGGGE 

« Hide

References

[1]"The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex."
Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., de Jong B.C.
PLoS Negl. Trop. Dis. 6:E1552-E1552(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GM041182 EMBL CCC26678.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR878060 Genomic DNA. Translation: CCC26678.1.
RefSeqYP_004723292.1. NC_015758.1.

3D structure databases

ProteinModelPortalF8M859.
SMRF8M859. Positions 32-342.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC26678; CCC26678; MAF_16060.
GeneID10955608.
KEGGmaf:MAF_16060.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK03517.

Enzyme and pathway databases

BioCycMAFR572418:GJCK-1622-MONOMER.
UniPathwayUPA00253; UER00327.

Family and domain databases

HAMAPMF_00568. NadA_type2.
InterProIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00550. nadA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF8M859_MYCA0
AccessionPrimary (citable) accession number: F8M859
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)