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Protein
Submitted name:

Putative ATP dependent DNA ligase (ATP dependent polydeoxyribonucleotide synthase)

Gene

MAF_09470

Organism
Mycobacterium africanum (strain GM041182)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA ligase (ATP) activity Source: UniProtKB-EC
  3. DNA primase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: InterPro
  2. DNA repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Enzyme and pathway databases

BioCyciMAFR572418:GJCK-956-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative ATP dependent DNA ligase (ATP dependent polydeoxyribonucleotide synthase)Imported (EC:6.5.1.1Imported)
Gene namesi
Ordered Locus Names:MAF_09470Imported
OrganismiMycobacterium africanum (strain GM041182)Imported
Taxonomic identifieri572418 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000298: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8M4I3.
SMRiF8M4I3. Positions 2-289, 453-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR014146. DNA_pol_LigD_ligase_dom.
IPR002755. DNA_primase_S.
IPR014144. LigD_PE_domain.
IPR014145. LigD_pol.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF01896. DNA_primase_S. 1 hit.
PF13298. LigD_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02777. LigD_PE_dom. 1 hit.
TIGR02778. ligD_pol. 1 hit.
TIGR02779. NHEJ_ligase_lig. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8M4I3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGSASEQRVT LTNADKVLYP ATGTTKSDIF DYYAGVAEVM LGHIAGRPAT
60 70 80 90 100
RKRWPNGVDQ PAFFEKQLAL SAPPWLSRAT VAHRSGTTTY PIIDSATGLA
110 120 130 140 150
WIAQQAALEV HVPQWRFVAE PGSGELNPGP ATRLVFDLDP GEGVMMAQLA
160 170 180 190 200
EVARAVRDLL ADIGLVTFPV TSGSKGLHLY TPLDEPVSSR GATVLAKRVA
210 220 230 240 250
QRLEQAMPAL VTSTMTKSLR AGKVFVDWSQ NSGSKTTIAP YSLRGRTHPT
260 270 280 290 300
VAAPRTWAEL DDPALRQLSY DEVLTRIARD GDLLERLDAD APVADRLTRY
310 320 330 340 350
RRMRDASKTP EPIPTAKPVT GDGNTFVIQE HHARRPHYDF RLERDGVLVS
360 370 380 390 400
WAVPKNLPDN TSVNHLAIHT EDHPLEYATF EGAIPSGEYG AGKVIIWDSG
410 420 430 440 450
TYDTEKFHDD PHTGEVIVNL HGGRISGRYA LIRTNGDRWL AHRLKNQKDQ
460 470 480 490 500
KVFEFDNLAP MLATHGTVAG LKASQWAFEG KWDGYRLLVE ADHGAVRLRS
510 520 530 540 550
RSGRDVTAEY PQLRALAEDL ADHHVVLDGE AVVLDSSGVP SFSQMQNRGR
560 570 580 590 600
DTRVEFWAFD LLYLDGRALL GTRYQDRRKL LETLANATSL TVPELLPGDG
610 620 630 640 650
AQAFACSRKH GWEGVIAKRR DSRYQPGRRC ASWVKDKHWN TQEVVIGGWR
660 670 680 690 700
AGEGGRSSGV GSLLMGIPGP GGLQFAGRVG TGLSERELAN LKEMLAPLHT
710 720 730 740 750
DESPFDVPLP ARDAKGITYV KPALVAEVRY SEWTPEGRLR QSSWRGLRPD

KKPSEVVRE
Length:759
Mass (Da):83,625
Last modified:September 21, 2011 - v1
Checksum:i8E1B59E06A356B3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR878060 Genomic DNA. Translation: CCC26019.1.
RefSeqiYP_004722642.1. NC_015758.1.

Genome annotation databases

EnsemblBacteriaiCCC26019; CCC26019; MAF_09470.
GeneIDi10955239.
KEGGimaf:MAF_09470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR878060 Genomic DNA. Translation: CCC26019.1.
RefSeqiYP_004722642.1. NC_015758.1.

3D structure databases

ProteinModelPortaliF8M4I3.
SMRiF8M4I3. Positions 2-289, 453-759.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC26019; CCC26019; MAF_09470.
GeneIDi10955239.
KEGGimaf:MAF_09470.

Phylogenomic databases

KOiK01971.

Enzyme and pathway databases

BioCyciMAFR572418:GJCK-956-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR014146. DNA_pol_LigD_ligase_dom.
IPR002755. DNA_primase_S.
IPR014144. LigD_PE_domain.
IPR014145. LigD_pol.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF01896. DNA_primase_S. 1 hit.
PF13298. LigD_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02777. LigD_PE_dom. 1 hit.
TIGR02778. ligD_pol. 1 hit.
TIGR02779. NHEJ_ligase_lig. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex."
    Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R., Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F., Adegbola R.A., Parkhill J., de Jong B.C.
    PLoS Negl. Trop. Dis. 6:E1552-E1552(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GM041182Imported.

Entry informationi

Entry nameiF8M4I3_MYCA0
AccessioniPrimary (citable) accession number: F8M4I3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.